Multimodal integration to identify the invasion status of lung adenocarcinoma intraoperatively.

Evaluating the invasiveness of lung adenocarcinoma is crucial for determining the appropriate surgical strategy, impacting postoperative outcomes. This study developed a multimodality model combining radiomics, intraoperative frozen section (FS) pathology, and clinical indicators to predict invasion status. The study enrolled 1,424 patients from two hospitals, divided into multimodal training, radiology testing, and pathology testing cohorts.

Corrigendum: Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes.

[This corrects the article DOI: 10.3389/fphar.2024.

The effectiveness of revocable precommitment strategies in reducing decision-making impulsivity.

Precommitment shows promise in reducing decision-making impulsivity; however, it may be invalidated, leading to self-control failures. Therefore, this study aimed to explore the effectiveness of revocable precommitment in promoting commitment and reducing decision-making impulsivity through two studies. Experiment 1 used event-related potentials to explore whether revocable precommitment was beneficial to make individuals more inclined to commit.

Phosphorylation-induced SUMOylation promotes Ulk4 condensation at ciliary tip to transduce Hedgehog signal.

Hedgehog (Hh) signaling controls embryonic development and adult tissue homeostasis through the Gli family of transcription factors. In vertebrates, Hh signal transduction depends on the primary cilium where Gli is thought to be activated at the ciliary tip, but the underlying mechanism has remained poorly understood. Here we provide evidence that two Unc-51-like kinase (Ulk) family members Stk36 and Ulk4 regulate Gli2 ciliary tip localization and activation through phosphorylation and SUMOylation-mediated condensation in response to Shh.

Mannose/stearyl chloride doubly functionalized polyethylenimine as a nucleic acid vaccine carrier to promote macrophage uptake.

Transmembrane transport remains a significant challenge for nucleic acid vaccine vectors. Promoting the ability of immune cells, such as macrophages, to capture foreign stimuli is also an effective approach to improving cross-presentation. In addition, polyethyleneimine (PEI) has gained attention in the field of nucleic acid vaccine carriers due to its excellent gene transfection efficiency and unique proton buffering effect.

Boronic acid functionalized of covalent organic framework for high performance capture of trace phthalates.

In order to improve the enrichment performance of parent covalent organic frameworks (COFs), boronic acid functionalized of COF (COF-B(OH)) was obtained by a simple standing method for the first time. The obtained COF-B(OH) exhibited the new characteristics that were not possessed by pure COF and was employed as the solid phase microextraction (SPME) coating material for highly efficient enrichment of trace endocrine disruptors phthalates (PAEs). Compared to pure COF, the synergistic effect of the newly emerged unique pore structure and boric acid interaction sites, and the large specific surface area and the abundant benzene ring structure inherited by original COF framework endowed COF-B(OH) with enhanced enrichment performance for PAEs.

Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes.

Objective: The limited ability to regenerate axons after spinal cord injury (SCI) is influenced by factors such as astrocyte activation, reactive proliferation, and glial scar formation. The TGF-β/Smad (transforming growth factor-β/mothers against decapentaplegic homolog) pathway, associated with astrocytic scarring, plays a crucial role in recovery post-injury. This study aims to investigate how icariin (ICA) interacts with reactive astrocytes in the treatment of spinal cord injury.

EndoC-βH3 pseudoislets are suitable for intraportal transplantation in diabetic mice.

Background: Islet or β-cell transplantation is a therapeutical approach to substitute the insulin-producing cells which are abolished in type 1 diabetes mellitus. The shortage of human islets as well as the complicated and costly isolation process limit the application of these techniques in daily clinical practice. EndoC-βH is a human β-cell line that readily forms aggregates termed pseudoislets, providing an alternative to primary human islets or β-cells.

Elastin-like polypeptide-functionalized nanobody for column-free immunoaffinity purification of aflatoxin B.

A column-free immunoaffinity purification (CFIP) technique for sample preparation of aflatoxin B (AFB) was developed using an AFB-specific nanobody (named G8) and an elastin-like polypeptide (ELP). The reversible phase transition between liquid and solid in response to temperature changes was exhibited by the ELP which was derived from human elastin. The G8 was tagged with ELPs of various lengths (20, 40, 60, and 80 repeat units) at the C-terminus using recursive directional ligation (RDL).

UAMC-3203 inhibits ferroptosis and promotes functional recovery in rats with spinal cord injury.

Spinal cord injury (SCI) results in irreversible neurological impairment. After SCI, Ferritinophagy-induced free iron released from ferritin can lead to extensive lipid peroxidation and aggravate neurological damage. NRF2/HO-1 pathway is to endow cells with a protective effect against oxidative stress, and it plays an important role in the transcriptional activation of a series of antioxidant and detoxification genes.

Hydrogen Bonding Chemistry in Aqueous Ammonium Ion Batteries.

Aqueous ammonium ion batteries (AIBs) pose the advantages of high safety, low cost, and high efficiency, capturing substantial research interest. The intrinsic chemical properties of NH promote the formation of hydrogen bonds with other constituents in AIBs, critically influencing the processes of NH transfer, storage, and diffusion. This review delves into the pivotal role of hydrogen bonding chemistry in AIBs.

Effect of Paravertebral Muscle Degeneration on Lumbar and Pelvic Sagittal Alignment in Patients With Degenerative Scoliosis.

Study Design: Retrospective study.

Objectives: To explore the relationship between lumbar spine muscle mass and lumbar pelvic sagittal parameters in patients with degenerative scoliosis.

Methods: This study included ADS patients who were treated in our hospital from 2019 to 2023.

Acceleration of Photoinduced Electron Transfer by Modulating Electronegativity of Substituents in Stable Zr-Metal-Organic Frameworks to Boost Photocatalytic CO Reduction.

Photoreduction of CO with water into chemical feedstocks of fuels provides a green way to help solve both the energy crisis and carbon emission issues. Metal-organic frameworks (MOFs) show great potential for CO photoreduction. However, poor water stability and sluggish charge transfer could limit their application.

Corrigendum: Efficacy and executive function of solution-focused brief therapy on adolescent depression.

[This corrects the article DOI: 10.3389/fpsyt.2024.

Higher Dietary Inflammatory Index and Increased Mortality Rate of Adults With Hyperuricemia: Findings From the National Health and Nutritional Examination Survey (2001-2018).

Objective: This study aimed to assess the association between Dietary Inflammatory Index (DII) score and death among adults with hyperuricemia.

Methods: We collected data from the 2001 to 2018 cohorts of the National Health and Nutritional Examination Survey. Death information was obtained based on death certificate records from the National Death Index through December 31, 2019.

Efficacy and executive function of solution-focused brief therapy on adolescent depression.

Objective: To investigate the efficacy and impact on executive function of Solution-Focused Brief Therapy (SFBT) in treating Major Depressive Disorder (MDD) in adolescents.

Methods: A total of 129 adolescents diagnosed with MDD were enrolled in the study. Out of these, 28 adolescents were assigned to the SFBT group, while 25 were part of the Active Control group (AC group), receiving psychodynamic psychotherapy.

Effects of acidification by traditional Jiaozi starter and neutralization with alkali (NaCO) on whole wheat dough properties.

Background: Whole wheat steamed bread has been recommended for its potential nutritional benefits to human health. Given the positive role of both organic acid and alkali in improving dough development and product quality, the present study investigated the effects of neutralization by addition of alkali (NaCO) after dough acidification with traditional Jiaozi starter on the properties of whole wheat dough.

Results: The population of yeast and lactic acid bacteria and the acidification level of the dough increased significantly after fermentation with Jiaozi.

The Relationship Between Harsh Parenting and Smartphone Addiction Among Adolescents: Serial Mediating Role of Depression and Social Pain.

Purpose: With the increasing prevalence of smart phones, adolescent smartphone addiction has garnered significant attention from researchers. Previous studies have revealed that smartphone addiction is associated with various internalization and externalization problems. Therefore, this present study aims to investigate the risk factors contributing to adolescent smartphone addiction.

The significance of glutaredoxins for diabetes mellitus and its complications.

Diabetes mellitus is a non-communicable metabolic disease hallmarked by chronic hyperglycemia caused by beta-cell failure. Diabetic complications affect the vasculature and result in macro- and microangiopathies, which account for a significantly increased morbidity and mortality. The rising incidence and prevalence of diabetes is a major global health burden.

Synergy of Dendrites-Impeded Atomic Clusters Dissociation and Side Reactions Suppressed Inert Interface Protection for Ultrastable Zn Anode.

The sluggish ions-transfer and inhomogeneous ions-nucleation induce the formation of randomly oriented dendrites on Zn anode, while the chemical instability at anode-electrolyte interface triggers detrimental side reactions. Herein, this report in situ designs a multifunctional hybrid interphase of Bi/BiO, for the first time resulting in a novel synergistic regulation mechanism involving: (i) chemically inert interface protection mechanism suppresses side reactions; and more fantastically, (ii) innovative thermodynamically favorable Zn atomic clusters dissociation mechanism impedes dendrites formation. Assisted by collaborative modulation behavior, the Zn@Bi/BiO symmetry cell delivers an ultrahigh cumulative plating capacity of 1.

The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain.

Acupuncture is a traditional medicinal practice in China that has been increasingly recognized in other countries in recent decades. Notably, several reports have demonstrated that acupuncture can effectively aid in pain management. However, the analgesic mechanisms through which acupuncture provides such benefits remain poorly understood.

Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance.

Purpose: To evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, and oxidative stress with impaired glucose tolerance (IGT) and insulin resistance (IR).

Methods: 120 individuals with IGT and IR were randomly divided into four groups treated with (1) chromium, (2) magnesium, (3) chromium and magnesium or (4) placebo. Metabolic and inflammatory indicators were measured at baseline and after 3 months intervention.