Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy.

The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy of cancer immunotherapy. Yet, the lack of effective strategies to induce TLS formation poses a substantial obstacle. Thus, the exploration of potential inducers for TLS formation is of great interest but remains challenging.

Identification and quantitation of multiplex camellia oil adulteration based on 11 characteristic lipids using UPLC-Q-Orbitrap-MS.

Currently, the identification and quantification of complex adulteration of high-value vegetable oils are still challenging. In this study, the extreme vertex design method was adopted to design representative multivariate adulterated camellia oil samples. Thereafter, 11 characteristic lipid species were identified by considering the statistically significant difference and categorical contribution.

Knockdown of the ZcVgR Gene Alters the Expression of Genes Related to Reproduction and Lifespan in Zeugodacus cucurbitae (Coquillett) Under Extreme Heat Conditions.

Zeugodacus cucurbitae (Coquillett) is an important migratory vegetable pest. Previous research has demonstrated that short-term high temperatures induce differential expression of the vitellogenin receptor (ZcVgR) gene, reducing the number of eggs laid and the lifespan of female Z. cucurbitae.

Health prediction for king salmon via evolutionary machine learning with genetic programming.

King (Chinook) salmon is the only salmon species farmed in Aotearoa New Zealand and accounts for over half of the world's production of king salmon. Determining the health status of king salmon effectively is important for farming. However, it is a challenging task due to the complex biotic and abiotic factors that influence health.

is the pathogen of "Baotou" disease causing serious damage to cultivation in China.

In recent years, a disease called "Baotou" has been causing large-scale yield reductions of in China. Interestingly, , which once reported to be a probiotic or pathogen for multiple marine organisms, was strongly proved to be the pathogen causing "Baotou" disease in this study. Analysis of 16S rRNA gene profiling revealed that was the most abundant and dominant bacterium on the algal thalli suffering from "Baotou" disease, whereas its presence was scarcely detected on healthy thalli.

Cytochrome P450-derived Epoxyeicosatrienoic Acid, the Regulation of Cardiovascular-related Diseases, and the Implication for Pulmonary Hypertension.

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid (AA) into biologically active epoxyeicosatrienoic acids (EETs), forming a pivotal metabolic pathway (AA-CYP-EETs-soluble epoxide hydrolase-dihydroxyeicosatrienoic acids) implicated in the progression of various disorders. Inflammation is a key contributor to the onset and progression of numerous systemic diseases, and EETs play a significant role in mitigating inflammation. Extensive research highlights the cardiovascular protective effects of EETs, which include vasodilation, anti-hypertensive, and anti-atherosclerotic properties.

The prevalence of suboptimal health status among Chinese secondary school students and its relationship with family health: the mediating role of perceived stress and problematic internet use.

Background: The health status of secondary school students has received widespread attention, and family plays an extremely important role in protecting and promoting their health. However, the relationship between family health and suboptimal health status (SHS) among secondary school students and its underlying mechanisms are unclear. This study aims to understand the prevalence of SHS among Chinese secondary school students and analyze the relationship between family health and SHS, and examine the mediating roles of perceived stress and problematic internet use.

Zdhhc1 deficiency mitigates foam cell formation and atherosclerosis by inhibiting PI3K-Akt-mTOR signaling pathway through facilitating the nuclear translocation of p110α.

Monocyte-to-macrophage differentiation and subsequent foam cell formation are key processes that contribute to plaque build-up during the progression of atherosclerotic lesions. Palmitoylation enzymes are known to play pivotal roles in the development and progression of inflammatory diseases. However, their specific impact on atherosclerosis development remains unclear.

Comparative analysis of the PAL gene family in nine citruses provides new insights into the stress resistance mechanism of Citrus species.

Background: The phenylalanine ammonia-lyase (PAL) gene, a well-studied plant defense gene, is crucial for growth, development, and stress resistance. The PAL gene family has been studied in many plants. Citrus is among the most vital cash crops worldwide.

Effect of NaCl on the structure and digestive properties of heat-treated myofibrillar proteins.

During meat processing, the quality of food and structure of meat proteins are affected by different processing technologies and addition of raw and auxiliary materials. Different meat products are treated with varying processing temperatures and NaCl content, changing the protein molecular structure. This study aimed to determine impact of heating temperature (40-115 °C) and NaCl concentration (0-0.

Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF-BB.

Background: Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. However, to date, there is a paucity of research documenting the changes in metabolome profiles within the supernatants of pulmonary artery smooth muscle cells (PASMC) during their transition from a contractile to a synthetic phenotype.

Methods: CCK-8 and Edu staining assays were used to evaluate the cell viability and proliferation of human PASMCs.

The relationship between fear of negative evaluation, physical activity, eating behavior and psychological distress among nursing students.

Background: The aim of this research is to explore the interrelationships between different psychological issues and the potential role of eating behavior and physical activity among nursing students.

Methods: Undergraduate nursing students ( = 892) from some medical universities in China were recruited through convenience and snowball sampling methods using online platforms. Participants completed measures on demographics, fear of negative evaluation (FNE), social avoidance and distress (SAD), psychological distress (DASS), disordered eating behavior (TFEQ) and physical activity.

NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies.

Neuroinflammation is a critical component in neurodegenerative disorders. The inflammasome, facilitates the cleavage of caspase-1, leading to the maturation and subsequent secretion of inflammatory factors interleukin (IL)-1β and IL-18. Consequently, pyroptosis mediated by gasdermin D, exacerbates neuroinflammation.

Photogeneration of β-Borylsilyl Radical via Decarboxylation of -Hydroxyphthalimide Esters.

-borylsilylalkanes are versatile intermediates in organic synthesis, and the traditional synthesis methods have mainly focused on metal reagents, the insertion reactions of diazo compounds, and hydrosilylation/hydroborylation reactions of unsaturated bonds. Herein, a novel, efficient -borylsilylalkanes synthesis via a radical approach is reported. This method introduced a β--borylsilyl NHPI ester as the precursor of the β-borylsilyl radical that, coupling with radical acceptors under photo conditions, and the corresponding -borylsilylalkanes bearing unsaturated bonds, facilitate subsequent transformations.

Socioeconomic status and depression in later life: longitudinal mediation effects of activities of daily living.

Background: Socioeconomic status (SES) is associated with both depression and activities of daily living (ADL and IADL). However, the role of ADL as a biological mechanism in the relationship between SES and late-life depression, examined through longitudinal data, remains understudied. This study explored the longitudinal mediation effects of basic ADL or IADL on the SES-depression link in older adults.

Structural characterization and immunoregulatory mechanism of a low-molecular-weight polysaccharide from lotus root.

The extraction of polysaccharide from lotus root was highly homogenized, and the structure of the polysaccharide was not clear. Herein, we report a hot water method combined with α-amylase that was applied to extract lotus root polysaccharide. After purified, a lotus root polysaccharide fraction LP60-a with high purity and low molecule weight was obtained.

CircRNA based multivalent neuraminidase vaccine induces broad protection against influenza viruses in mice.

Developing broad-spectrum influenza vaccines is crucial for influenza control and potential pandemic preparedness. Here, we reported a novel vaccine design utilizing circular RNA (circRNA) as a delivery platform for multi-subtype neuraminidases (NA) (influenza A N1, N2, and influenza B Victoria lineage NA) immunogens. Individual NA circRNA lipid nanoparticles (LNP) elicited robust NA-specific antibody responses with neuraminidase inhibition activity (NAI), preventing the virus from egressing and infecting neighboring cells.