Publications by authors named "Meng-Zhuan Han"
Article Synopsis
- S1P (sphingosine-1-phosphate) is identified to induce vasodilation in mouse mesenteric arteries through activation of calcium-activated potassium channels (K2.3 and K3.1), with effects dependent on intracellular calcium levels.
- The study reveals that chronic S1P stimulation enhances the expression of K2.3 and K3.1 channels in endothelial cells, regulated by the S1P receptor (S1PR1) and downstream Ca signaling pathways.
- Deletion of S1PR1 leads to reduced K2.3 and K3.1 expression and increased hypertension in a mouse model, highlighting the importance of endothelium-dependent hyperpolarization in managing vascular responses and blood
Background: Vascular endothelial dysfunction is regarded as an early event of hypertension. Galectin-3 (Gal-3) is known to participate in various pathological processes. Whilst previous studies showed that inhibition of Gal-3 effectively ameliorates angiotensin II (Ang II)-induced atherosclerosis or hypertension, it remains unclear whether Ang II regulates Gal-3 expression and actions in vascular endothelium.
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