Publications by authors named "Meng-Zhang He"
Significance and Potential Role of Eosinophils in Non-Cystic Fibrosis Bronchiectasis.
J Allergy Clin Immunol Pract
April 2023
Bronchiectasis is a complex and heterogeneous disease with a myriad of pulmonary and extrapulmonary etiologies. Bronchiectasis has a predominantly neutrophilic inflammatory profile. However, eosinophilic inflammation has also been documented in both the airways and the systemic circulation.
View Article and Find Full Text PDFObjective: To investigate the effects of budesonide (BUD) on the airway remodeling and the expression of Janus protein tyrosine kinases 1 (JAK1) and signal transducer and activator of transcription 6 (STAT6) in asthma.
Methods: Thirty female Balb/c mice were randomly divided into 3 equal groups: control group; asthma group, sensitized on day 1, 8, and 15 and challenged from day 21 to 52 with periodically repeated intranasal drip of ovalbumin (OVA); and BUD treated group, undergoing intranasal drip of OVA as mentioned above and intranasal administration of BUD 2 hours before each OVA challenge. 24 h after the final OVA inhalation an invasive single-chamber whole body plethysmograph was used to assess the airway responsiveness.
[Etiology and a diagnostic protocol for patients with chronic cough].
Zhonghua Jie He He Hu Xi Za Zhi
February 2006
Objective: The spectrum and frequency of causes and the diagnostic protocol for chronic cough were explored.
Methods: A total of 194 patients with at least 3 weeks of chronic cough and normal chest radiographs were recruited from the outpatient clinic of Guangzhou Institute of Respiratory Diseases between July 2003 to June 2004. The causes were investigated using a well-established protocol.
[Characteristics of airway inflammatory cells and mediators in eosinophilic bronchitis patients].
Zhonghua Jie He He Hu Xi Za Zhi
September 2005
Article Synopsis
- - The study analyzed airway inflammation in patients with eosinophilic bronchitis (EB) by examining sputum and bronchoalveolar lavage fluid (BALF) from various groups, including patients with cough variant asthma (CVA), bronchial asthma, and healthy controls.
- - Results indicated that patients with EB had a significant percentage of eosinophils in their sputum compared to healthy controls, and differences in inflammatory mediators like eosinophilic cationic protein (ECP) and leukotriene C(4) were also observed across the groups.
- - The findings suggest that eosinophilic infiltration is primarily localized to the central airways in EB, highlighting distinct inflammatory features compared to CVA and asthma patients
Objective: Gastro-esophageal reflux (GER) is an important etiological factor inducing chronic cough. This study aims to identify the clinical features for the diagnosis of GER induced cough (GERC).
Methods: A modified Irwin's diagnostic protocol and continuous 24-hour esophageal pH monitoring were performed in 50 patients with chronic cough.