Publications by authors named "Meng-Yao Niu"
Article Synopsis
- * USP36 removes ubiquitin chains from proteins, which leads to their degradation through the proteasome, and its functions are linked to various health issues like cancer, infections, and inflammation.
- * This review aims to summarize current research on USP36's roles in diseases, enhancing our understanding of the underlying mechanisms and highlighting potential targets for therapeutic intervention.
Front Pharmacol
September 2022
Article Synopsis
- Breast cancer (BC) is the most commonly diagnosed cancer globally since 2020, and histone methylation plays a significant role in its development.
- Lysine-specific demethylase 1 (LSD1) is a key enzyme that removes methyl groups from histones and is implicated in cancer progression, particularly in breast cancer through various mechanisms.
- The review discusses LSD1's structure, its mechanisms of action in breast cancer, the potential of LSD1 inhibitors as a treatment, and the future challenges and opportunities in targeting LSD1 for BC therapy.
