CT radiomic features reproducibility of virtual non-contrast series derived from photon-counting CCTA datasets using a novel calcium-preserving reconstruction algorithm compared with standard non-contrast series: focusing on epicardial adipose tissue.

Purpose: We aimed to evaluate the reproducibility of computed tomography (CT) radiomic features (RFs) about Epicardial Adipose Tissue (EAT). The features derived from coronary photon-counting computed tomography (PCCT) angiography datasets using the PureCalcium (VNC) and conventional virtual non-contrast (VNC) algorithm were compared with true non-contrast (TNC) series.

Methods: RFs of EAT from 52 patients who underwent PCCT were quantified using VNC, VNC, and TNC series.

Astrocyte-neuron communication mediated by the Notch signaling pathway: focusing on glutamate transport and synaptic plasticity.

Maintaining glutamate homeostasis after hypoxic ischemia is important for synaptic function and neural cell activity, and regulation of glutamate transport between astrocyte and neuron is one of the important modalities for reducing glutamate accumulation. However, further research is needed to investigate the dynamic changes in and molecular mechanisms of glutamate transport and the effects of glutamate transport on synapses. The aim of this study was to investigate the regulatory mechanisms underlying Notch pathway mediation of glutamate transport and synaptic plasticity.