Increased Plasma Levels of S100A8, S100A9, and S100A12 in Chronic Spontaneous Urticaria.

Background: Chronic spontaneous urticaria (CSU) is a skin disorder with an important immunologic profile. S100A8, S100A9, and S100A12 are the members of S100 family that have been reported to play important role in autoimmune diseases, but the characteristics of these three S100 members have not been defined in CSU.

Aims: This study was performed to investigate the levels of these three S100s in patients with CSU and to study whether they were associated with the severity and clinical characteristics of CSU.

Repression of M-phase phosphoprotein 8 inhibits melanoma growth and metastasis and .

Metastatic melanoma accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies. M-phase phosphoprotein 8 (MPP8) has been shown to bind to methylated H3K9 and promote tumor cell motility and invasion. The current study aimed to investigate the role of MPP8 in melanoma growth and metastasis.