Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6C macrophages through activating the cytokine-paracrine and apoptotic pathways.

Mesenchymal stem cell (MSC) therapy has become a promising treatment for liver fibrosis due to its predominant immunomodulatory performance in hepatic stellate cell inhibition and fibrosis resolution. However, the cellular and molecular mechanisms underlying these processes remain limited. In the present study, we provide insights into the functional role of bone marrow-derived MSCs (BM-MSCs) in alleviating liver fibrosis by targeting intrahepatic Ly6C and Ly6C macrophage subsets in a mouse model.

Estimation of rice phenology date using integrated HJ-1 CCD and Landsat-8 OLI vegetation indices time-series images.

Accurate estimation of rice phenology is of critical importance for agricultural practices and studies. However, the accuracy of phenological parameters extracted by remote sensing data cannot be guaranteed because of the influence of climate, e.g.