Folium Sennae and emodin reverse airway smooth muscle contraction.

The objective of this project was to find a bronchodilatory compound from herbs and clarify the mechanism. We found that the ethanol extract of Folium Sennae (EEFS) can relax airway smooth muscle (ASM). EEFS inhibited ASM contraction, induced by acetylcholine, in mouse tracheal rings and lung slices.

[Ethacrynic acid inhibits airway smooth muscle contraction in mice].

The aim of this study was to investigate the inhibitory effect and the underlying mechanism of ethacrynic acid (EA) on the contraction in mice. BL-420S force measuring system was used to measure the tension of mouse tracheal rings. The whole cell patch clamp technique was utilized to record the channel currents of airway smooth muscle (ASM) cells.

NS8593 inhibits Ca permeant channels reversing mouse airway smooth muscle contraction.

Aims: This study focused on investigating whether NS8593 reverses airway smooth muscle (ASM) contraction and the underlying mechanism.

Main Methods: ASM contraction in mouse tracheal rings and lung slices was measured. Currents mediated by voltage dependent Ca channels (VDCCs) and ACH-activated channels were measured using the whole-cell patch-clamp technique in single tracheal smooth muscle cells (TSMCs).