Active Ingredients of Reduning Injection Maintain High Potency against SARS-CoV-2 Variants.

Objective: To investigate the anti-coronavirus potential and the corresponding mechanisms of the two ingredients of Reduning Injection: quercetin and luteolin.

Methods: A pseudovirus system was designed to test the efficacy of quercetin and luteolin to inhibit SARS-CoV-2 infection and the corresponding cellular toxicity. Luteolin was tested for its activities against the pseudoviruses of SARS-CoV-2 and its variants.

Parametric study of anterior percutaneous endoscopic cervical discectomy (APECD).

Anterior percutaneous endoscopic cervical discectomy (APECD) is a common treatment for cervical spondylotic radiculopathy (CSR). In this study, the effects of various channel diameters and approach angles on cervical vertebrae on postoperative outcomes in APECD surgery were explored. A finite element model of intact cervical C-C was constructed and then modified to obtain six surgical models.

Does oblique lumbar interbody fusion promote adjacent degeneration in degenerative disc disease: A finite element analysis.

Background: The number of oblique lumbar interbody fusion (OLIF) procedures has continued to rise over recent years. Adjacent segment degeneration (ASD) is a common complication following vertebral body fusion. Although the precise mechanism remains uncertain, ASD has gradually become more common in OLIF.

Application of Simulation Methods in Cervical Spine Dynamics.

Neck injury is one of the most frequent spine injuries due to the complex structure of the cervical spine. The high incidence of neck injuries in collision accidents can bring a heavy economic burden to the society. Therefore, knowing the potential mechanisms of cervical spine injury and dysfunction is significant for improving its prevention and treatment.

Biomechanical Effect of L -L Intervertebral Disc Degeneration on the Lower Lumbar Spine: A Finite Element Study.

Objective: To ascertain the biomechanical effects of a degenerated L -L segment on the lower lumbar spine through a comprehensive simulation of disc degeneration.

Methods: A three-dimensional nonlinear finite element model of a normal L -S lumbar spine was constructed and validated. This normal model was then modified such that three degenerated models with different degrees of degeneration (mild, moderate, or severe) at the L -L level were constructed.