Publications by authors named "Meng-Qing Luo"
To assess the safety and effectiveness of oral methylprednisolone (oMP) in comparison with intramuscular adrenocorticotropic hormone (imACTH) and oral prednisolone (oP) therapies in children with infantile spasms (IS). In this prospective, open-label, non-blinded, uncontrolled observational study, children (aged 2-24 months) with newly diagnosed IS presenting with hypsarrhythmia or its variants on electroencephalogram (EEG) were included. It was followed by imACTH, oP, or oMP (32-48 mg/day for 2 weeks followed by tapering) treatments.
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- Acute necrotizing encephalopathy of childhood (ANE) is a rare and rapidly worsening brain condition with limited research on its causes and treatments, prompting a study to analyze outcomes in pediatric patients.
- The study included 41 patients, revealing that 17% died, while survivors exhibited varying degrees of neurological issues; certain factors like time from infection to encephalopathy and specific MRI findings were associated with worse outcomes.
- Early treatments such as steroids and intravenous immunoglobulin were found to have no significant impact on prognosis, while factors like the number of brain lesions and cavitation indicated poor recovery prospects.