Screening 5-lipoxygenase inhibitors from selected traditional Chinese medicines and isolation of the active compounds from Polygoni Cuspidati Rhizoma by an on-line bioactivity evaluation system.

To identify natural products as new prototypes for 5-lipoxygenase (5-LOX), 12 traditional Chinese medicines (TCMs) were selected for screening their 5-LOX inhibition activities. The results showed that the methanol extracts of all selected TCMs (n = 12) possessed inhibitory activities against 5-LOX at 200 μg/mL, of which six extracts of the TCMs showed significant inhibitory effects with IC values in the range from 33.2 ± 1.

Highly sensitive and selective determination of p-nitrophenol at an interpenetrating networks structure of self-assembled rod-like lanthanum hydroxide-oxidized multi-walled carbon nanotubes nanocomposite.

In this study, a novel electrochemical sensor based on self-assembled rod-like lanthanum hydroxide-oxidized multi-walled carbon nanotubes (La(OH)-OxMWCNTs) nanocomposite was developed for sensitive determination of p-nitrophenol (p-NP). The La(OH)-OxMWCNTs nanocomposite with an interpenetrating networks structure was characterized by field emission electron microscope (FE-SEM), Fourier transform infrared (FT-IR) spectroscopy, Raman spectra and X-ray photoelectron spectroscopy (XPS). The cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) measurements were performed to study the electrochemical behaviors of La(OH)-OxMWCNTs modified glassy carbon electrode (La(OH)-OxMWCNTs/GCE).

PtNPs-GNPs-MWCNTs-β-CD nanocomposite modified glassy carbon electrode for sensitive electrochemical detection of folic acid.

A novel electrochemical sensor, platinum nanoparticles/graphene nanoplatelets/multi-walled carbon nanotubes/β-cyclodextrin composite (PtNPs-GNPs-MWCNTs-β-CD) modified carbon glass electrode (GCE), was fabricated and used for the sensitive detection of folic acid (FA). The PtNPs-GNPs-MWCNTs-β-CD nanocomposite was easily prepared with an ultrasound-assisted assembly method, and it was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The electrochemical behavior of FA at PtNPs-GNPs-MWCNTs-β-CD/GCE was investigated in detail.

Highly-sensitive and selective determination of bisphenol A in milk samples based on self-assembled graphene nanoplatelets-multiwalled carbon nanotube-chitosan nanostructure.

Graphene nanoplatelets (GNPs), multiwalled carbon nanotube (MWCNTs) and chitosan (CS) were self-assembled by a facile one-step hydrothermal reaction to obtain novel MWCNTs-CS enfolded GNPs (GNPs-MWCNTs-CS) composite. Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, scanning electron microscopy (SEM), UV-visible (UV-vis) absorption spectroscopy and zeta potential analysis were employed to characterize the morphology, surface composition, interaction, surface charge and stability of the GNPs-MWCNTs-CS composite. The electrochemical behaviors of GNPs-MWCNTs-CS composite modified glassy carbon electrode (GNPs-MWCNTs-CS/GCE) were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).

A novel electrochemical sensor based on self-assembled platinum nanochains - Multi-walled carbon nanotubes-graphene nanoparticles composite for simultaneous determination of dopamine and ascorbic acid.

In this study, platinum nanochains (PtNCs), multi-walled carbon nanotubes (MWCNTs) and graphene nanoparticles (GNPs) were assembled together to form a novel nanocomposite by a facile ultrasonic-assisted blending process. The PtNCs-MWCNTs-GNPs nanocomposite was characterized by high resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The nanocomposite was used for the modification of glass carbon electrode (GCE) and simultaneous determination of dopamine (DA) and ascorbic acid (AA) by differential pulse voltammetry (DPV) and cycle voltammetry (CV).