[Role and mechanism of histone deacetylases in mouse neuronal development].

Objective: To study the role and mechanism of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) in mouse neuronal development.

Methods: The mice with Synapsin1-Cre recombinase were bred with mice to obtain the mice with neuron-specific conditional knockout (knockout group), and their littermates without knockout were used as the control group. The general status of the mice was observed and survival curves were plotted.

Comparative genomic investigation of high-elevation adaptation in ectothermic snakes.

Several previous genomic studies have focused on adaptation to high elevations, but these investigations have been largely limited to endotherms. Snakes of the genus are endemic to the Tibetan plateau and therefore present an opportunity to study high-elevation adaptations in ectotherms. Here, we report the de novo assembly of the genome of a Tibetan hot-spring snake () and then compare its genome to the genomes of the other two species of , as well as to the genomes of two related species of snakes that occur at lower elevations.