Publications by authors named "Meng-Kai Hu"
Article Synopsis
- A fatal case of primary amoebic meningoencephalitis was linked to an indoor surfing center in Taiwan, identified through monitoring for encephalitis symptoms.
- Environmental testing revealed that 1 out of 56 specimens contained the Naegleria fowleri amoeba.
- The report highlights the dangers of N. fowleri infections from poorly disinfected recreational water, including indoor facilities.
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive disease that impairs synthesis of dopamine and serotonin. Children with AADC deficiency exhibit severe motor, behavioral, and autonomic dysfunctions. We previously generated an IVS6+4A>T knock-in mouse model of AADC deficiency (Ddc(KI) mice) and showed that gene therapy at the neonatal stage can rescue this phenotype.
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- Aromatic l-amino acid decarboxylase (AADC) is crucial for producing dopamine and serotonin, and its deficiency leads to developmental issues in children, particularly affecting motor skills.
- A study created a mouse model with an AADC gene mutation, resulting in significantly reduced AADC activity and severe dyskinesia, but some mice did survive to adulthood with compensatory adaptations.
- This new AADC deficient mouse model can aid in researching gene therapies for AADC deficiency and in developing treatments for related neurotransmitter disorders.