Outbreaks of hand, foot and mouth disease (HFMD) have occurred frequently in the Asian-Pacific region over the last two decades, caused mainly by the serotypes in species. High-quality monoclonal antibodies (mAbs) are needed to improve the accuracy and efficiency of the diagnosis of enteroviruses associated HFMD. In this study, a mAb 1A11 was generated using full particles of CV-A5 as an immunogen.
View Article and Find Full Text PDFHand, foot and mouth disease (HFMD) is caused by a variety of serotypes in species A of the Enterovirus genus, including recently re-emerged Coxsackievirus A2 (CV-A2), CV-A4 and CV-A5. For development of diagnostic reagents, for surveillance, and the development of multivalent vaccines against HFMD, the antigenicity of HFMD-associated enteroviruses warrants investigation. The purified virions of CV-A4 were inoculated into Balb/c mice and hybridomas were obtained secreting monoclonal antibodies (mAbs) directed against CV-A4 and cross-reacting with other closely related species A enteroviruses.
View Article and Find Full Text PDFMinerva Endocrinol (Torino)
February 2022
Background: Linagliptin is a convenient and effective drug approved for glycemic management in type 2 diabetes mellitus (T2DM). However, the effectiveness and safety evidence of linagliptin remains unclear with the increasing prevalence of T2DM in elderly patients.
Objective: For evaluating the effectiveness and safety of linagliptin within T2DM cases who aged ≥60 years.
Medicine (Baltimore)
December 2021
Background: Ultrafiltration plays an indispensable role in relieving congestion and fluid retention in patients with acute decompensated heart failure (ADHF) in recent years. So far, there is no consistent agreement about whether early ultrafiltration (UF) is a first-line treatment for patients with ADHF. We, therefore, conducted a meta-analysis to assess the efficacy and safety of UF.
View Article and Find Full Text PDFRenal fibrosis is recognized as the common route of all chronic kidney disease (CKD) progressing to end-stage renal disease (ESRD). Additionally, accumulating evidence suggests that epithelial-mesenchymal transition (EMT) plays a significant role in the process of renal fibrogenesis. Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog that has been widely used to treat type 2 diabetes.
View Article and Find Full Text PDFThis study characterized the blood oxygen level-dependent (BOLD) fluctuations in benign and malignant musculoskeletal tumours via power spectrum analyses in pre-established low-frequency bands. BOLD MRI and T1-weighted imaging (T1WI) were collected for 52 patients with musculoskeletal tumours. Three ROIs were drawn on the T1WI image in the tumours' central regions, peripheral regions and neighbouring tissue.
View Article and Find Full Text PDFGuang Pu Xue Yu Guang Pu Fen Xi
October 2015
It is important to real-timely monitor and control the temperature of cell physiological solution in patch clamp experiments, which can eliminate the uncertainty due to temperature and improve the measurement accuracy. This paper studies the influence of different ions at different concentrations in the physiological solution on precision of a temperature model by using near infrared spectroscopy and chemometrics method. Firstly, we prepared twelve sample solutions respectively with the solutes of CaCl2, KCl and NaCl at four kinds of concentrations, and collected the spectra of different solutions at the setting temperature range 20-40 degrees C, the range of the spectra is 9 615-5 714 cm(-1).
View Article and Find Full Text PDFBackground: Abies faxoniana is the dominant plant species of the forest ecosystem on the eastern edge of Qinghai-Tibet Plateau, where the treeline is strongly defined by climate. The tree-ring chronologies and age structure of Abies faxoniana were developed in the treeline ecotones on the northwestern and southeastern aspects of the Min Mountains in the Wanglang Nature Reserve to examine the treeline dynamics of recent decades in response to climate change.
Results: On the northwestern aspect, correlation analysis showed that the radial growth was significantly and positively correlated with precipitation in current January and monthly mean temperature in current April, but significantly and negatively correlated with monthly mean temperature in previous August.
Guang Pu Xue Yu Guang Pu Fen Xi
November 2012
To realize the noninvasive concentration detection of blood components and improve the drawbacks existing in the time-domain single-trial estimation method of "dynamic spectrum" (DS), the D-value estimation method based on the statistical properties was proposed. We extracted the absolute difference between two corresponding values of each wavelength to make up the DS, selected the valid DSs from the DSs of different times by statistic method, and the valid DSs were superimposed and averaged as the final output of the DS. Data collected from 48 volunteers were processed by the D-value estimation and the single-trial estimation, respectively; and then the comparison was carried out between the two methods.
View Article and Find Full Text PDFGuang Pu Xue Yu Guang Pu Fen Xi
August 2012
The multi-dimensional diffuse transmittance spectrums were collected by the traditional near-infrared transmittance method combined with a scanning device, and then used for component analysis of the complex mixed solution. A xenon light, an electric control translation stage and a spectrometer were gathered to set up a device; Intralipid-20%, India-ink and C6H12O6 were used to prepare 225 kinds of complex mixed solutions; the diffuse transmittance spectrums were measured at 20 points off the transmission center distributed from 0-5 mm (interval 0.25 mm); the single and multi-point diffuse transmittance spectrums were analyzed by partial least squares regression for modeling and prediction.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
June 2008
By using CIRAS-2 portable photosynthesis system, the light response processes of Aralia elata photosynthesis and transpiration under different soil moisture conditions were studied, aimed to understand the adaptability of A. elata to different light and soil moisture conditions. The results showed that the response processes of A.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
May 2007