Publications by authors named "Meng-Hui Gui"
Article Synopsis
- - Hepatocellular carcinoma (HCC) is the leading form of liver cancer, known for its aggressive nature and complex mechanisms, particularly involving the RNA-binding protein PTBP1 which influences splicing events in cancer cells.
- - The study revealed that PTBP1 alters the expression of FGFR2 isoforms, reducing the tumor-suppressive FGFR2-IIIb while increasing the tumor-promoting FGFR2-IIIc in HCC cells, indicating a significant role in cancer progression.
- - Functional assays showed that the switch from FGFR2-IIIb to FGFR2-IIIc contributes to the aggressive nature of HCC by promoting epithelial-mesenchymal transformation (EMT) and activating key signaling pathways
