Effectiveness of an integrated CPOE decision-supporting system with clinical pharmacist monitoring practice in preventing antibiotic dosing errors.

Objective: Computer-prescriber order entry (CPOE) systems that lack clinical decision components actually increase errors and cause harm rather than the opposite. Recent studies have also demonstrated that dosing errors, typing errors, or miscommunication with other systems are the most common CPOE errors. Our objective was to develop an antibiotic dosing calculator and implement it in the CPOE system while integrating the role of the clinical pharmacist in the CPOE in order to minimize dosing errors in the prescription of antibiotics.

Inheritable genetic algorithm for biobjective 0/1 combinatorial optimization problems and its applications.

In this paper, we formulate a special type of multiobjective optimization problems, named biobjective 0/1 combinatorial optimization problem BOCOP, and propose an inheritable genetic algorithm IGA with orthogonal array crossover (OAX) to efficiently find a complete set of nondominated solutions to BOCOP. BOCOP with n binary variables has two incommensurable and often competing objectives: minimizing the sum r of values of all binary variables and optimizing the system performance. BOCOP is NP-hard having a finite number C(n, r) of feasible solutions for a limited number r.