Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers.

It has been shown that cytochrome P4501B1 (CYP1B1) is over-expressed in variety of tumors. The objective of this study was to examine the expression and localization of CYP1B1 in normal lungs and tumor tissues of non-small cell lung cancers (NSCLC). CYP1B1 was detectable in the microsomes of normal lungs and lung tumors with Western immunoblotting.

Overexpression of aryl hydrocarbon receptor in human lung carcinomas.

Exposure to polycylic aromatic hydrocarbons (PAH) has been associated with increased risk of lung cancer. Aryl hydrocarbon receptor (AhR) is known to play an essential role in PAH-induced toxicity. The objectives of this study were to identify and evaluate AhR expression in normal human lung tissues and in lung carcinomas.