Publications by authors named "Meng-Ge Feng"
Existing Forms of Notoginsenoside R in Rats and Their Potential Bioactivities.
J Agric Food Chem
December 2024
Article Synopsis
- - Notoginsenoside R (NG-R), a key saponin in a medicinal plant, was analyzed using advanced UHPLC-ESI-Q-TOF-MS/MS techniques to identify its various forms and distribution in rats, resulting in the detection of 105 metabolites, including 89 new ones.
- - The study proposed a new fragmentation pathway for protopanaxatriol (PPT) and revealed novel metabolic reactions for NG-R, such as polyhydroxylation and glucuronidation, with significant metabolite accumulation observed in various organs.
- - Predictive analyses suggested 48 metabolites may have therapeutic effects on three diseases, with follow-up experiments confirming anti-tumor and anti-inflammatory properties in eight specific
Ethnopharmacological Relevance: Astragali Radix-Saposhnikoviae Radix (AR-SR) is a well-known and effective herb pair. Although the compatibility of these two herbs has been widely applied in many traditional Chinese medicine formulas, its potential mechanism still needs to be investigated.
Aim Of Study: To evaluate the pharmacokinetic profiles of 10 bioactive compounds derived from AR when administrated alone and in combination with SR to rats, aiming to further reveal the impact of SR on AR.