Publications by authors named "Meng-Dan Lv"
Article Synopsis
- Autism spectrum disorder (ASD) is linked to genetic susceptibility and environmental factors, particularly maternal infections during pregnancy which increase autism risk in children.
- Research utilizing a maternal immune activation (MIA) model showed that MIA causes autistic behaviors due to specific changes in the brain, such as microglia activation and dendritic spine abnormalities in the prefrontal cortex (PFC).
- The overexpression of NKCC1, a key protein in these processes, was identified as a contributor to these changes, and the use of the NKCC1 inhibitor bumetanide successfully reduced autistic behaviors in affected offspring.
Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, and its specific pathogenesis is still unclear. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized in a rat model of visceral hypersensitivity induced by neonatal colonic inflammation (NCI). However, the detailed molecular mechanism for activation of sodium channels remains unknown.
View Article and Find Full Text PDFEvolutionarily conserved DDB1-and CUL4-associated factor 13 (DCAF13) is a recently discovered substrate receptor for the cullin RING-finger ubiquitin ligase 4 (CRL4) E3 ubiquitin ligase that regulates cell cycle progression. DCAF13 is overexpressed in many cancers, although its role in breast cancer is currently elusive. In this study we demonstrate that DCAF13 is overexpressed in human breast cancer and that its overexpression closely correlates with poor prognosis, suggesting that DCAF13 may serve as a diagnostic marker and therapeutic target.
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