Publications by authors named "Meng-Cheng Yao"
Article Synopsis
- The South China tiger, once widely distributed, is now extinct in the wild, with all living members stemming from a small group of just six original tigers captured decades ago.
- Recent research revealed two distinct genomic lineages among these tigers, indicating some level of genetic diversity despite concerns about inbreeding and hybridization with other tiger subspecies.
- The study highlighted a successful genetic purging of harmful mutations, suggesting effective management of the species' genetic health, and contributes valuable genomic data for future conservation efforts.
Article Synopsis
- Environmental enrichment (EE) helps in stroke recovery by promoting brain healing and repair, but the exact way it works is still not fully understood.
- Researchers studied HDAC2, a protein that slows down brain recovery, and found that it increases after a stroke.
- They discovered that EE lowers HDAC2 levels, helping mice recover better from strokes, and suggest that targeting HDAC2 could be a new way to improve recovery for people who have had strokes.
Background: Stroke is a leading cause of long-term disability worldwide. However, current therapies that promote functional recovery from stroke are limited to physical rehabilitation. No pharmacological therapy is available.
View Article and Find Full Text PDFNarrow therapeutic window limits treatments with thrombolysis and neuroprotection for most stroke patients. Widening therapeutic window remains a critical challenge. Understanding the key mechanisms underlying the pathophysiological events in the peri-infarct area where secondary injury coexists with neuroplasticity over days to weeks may offer an opportunity for expanding the therapeutic window.
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