Multiomics joint analysis reveals the potential mechanism of differences in the taproot thickening between cultivated ginseng and mountain-cultivated ginseng.

Panax ginseng is an important medicinal plant in China and is classified into two types: cultivated ginseng (CFCG) and mountain-cultivated ginseng (MCG). The two types of genetic varieties are the same, but the growth environments and management practices are different, resulting in substantial differences in their taproot morphology. Currently, there is a paucity of research on the internal mechanisms that regulate the phenotypic differences between cultivated ginseng and mountain-cultivated ginseng.

Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases.

Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu. Deregulated communication between mitochondria and host cells/organelles has significant consequences and is an underlying factor of many pathophysiological conditions, including the process of aging. During aging, mitochondria lose function, and mitocellular communication pathways break down; mitochondrial dysfunction interacts with mitochondrial dyscommunication, forming a vicious circle.

Engineering a Binding Peptide for Oriented Immobilization and Efficient Bioelectrocatalytic Oxygen Reduction of Multicopper Oxidases.

Enzymatic fuel cells (EFCs) are emerging as promising technologies in renewable energy and biomedical applications, utilizing enzyme catalysts to convert the chemical energy of renewable biomass into electrical energy, known for their high energy conversion efficiency and excellent biocompatibility. Currently, EFCs face challenges of poor stability and catalytic efficiency at the cathodes, necessitating solutions to enhance the oriented immobilization of multicopper oxidases for improved heterogeneous electron transfer efficiency. This study successfully identified a surface-binding peptide (SBP, 13 amino acids) derived from a methionine-rich fragment (MetRich, 53 amino acids) in CueO through semirational design.

A DNA tweezer-actuated nanozyme-enzyme hybrid nanoreactor for pesticide detection.

The construction of a nanozyme-enzyme hybrid cascade system is an effective protocol to optimize the performance of biosensors. Yet, the integration has limitations due to the lack of harmonious collaboration between nanozyme and enzyme. Herein, we have constructed an efficient enzymatic cascade system by utilizing the base complementary pairing and the targeting capability of DNA tweezers to combine DNA-regulated copper nanoflowers (CuNFs) with acetylcholinesterase (AChE).

Regulating the Atomic Active Center by Covalent Organic Framework-Derived Photothermal Nanozyme to Arm Self-Gelling Powder for Bacterial Wound Healing.

Creating simple methods to produce antioxidant nanozymes with clear structure-activity relationships, particularly aiming to improve disinfection and create practical drug formulations for bacterial wound healing, remains a crucial challenge. Herein, we synthesized iron-loaded covalent organic framework nanospheres, which were then controllably transformed into a carbon-based nanozyme with both iron single atoms and iron clusters through simple pyrolysis. We discovered that the gradual growth of iron clusters significantly boosted the nanozyme's adsorption onto the substrate and electron transfer, greatly influencing its activity.

High strength, self-activating ability and fast adhesion of polyurethane adhesives based on rosin structure in different environments.

Underwater adhesives hold significant relevance in daily life and applications. Despite great efforts, the development of high-performance underwater adhesives through a simple and effective method remains a difficult challenge. Herein, a high adhesion and environmentally stable polyurethane underwater adhesive (DAP-PU) was developed based on rosin with a hydrogenated phenanthrene ring skeleton to design hydrophobic domains, and combined with multi-strength hydrogen bonding interactions to construct "polar hydrophobic domains".

derived exosome-like nanovesicles alleviate restenosis after vascular injury through the Keap1/Nrf2 pathway.

Despite the significant alleviation of clinical cardiovascular diseases through appropriate interventional treatments, the recurrence of vascular restenosis necessitating reoperation remains a substantial challenge impacting patient prognosis. Plant-derived exosome-like nanovesicles (PELNs) are integral to interspecies cellular communication, with their functions and potential applications garnering significant attention from the research community. This study extracted -derived exosome-like nanovesicles (SL-ELNs) and demonstrated their inhibition of PDGF-BB-induced proliferation, migration, and phenotypic transformation of vascular smooth muscle cells (VSMCs).

Molecular characteristics, clonal transmission, and risk factors of among hospitalized patients in a tertiary hospital in Ningbo, China.

Background: Nosocomial transmission of infection (CDI) has been documented in Ningbo, China. However, data on molecular characteristics, clonal transmission, and risk factors of CDI in this region remain limited.

Methods: A cross-sectional study enrolled hospitalized patients with diarrhea during September to November 2021.

Activation characteristics of Ty3-retrotransposons after spaceflight and genetic stability of insertion sites in rice progeny.

Introduction: The space environment is mutagenic and may induce genomic and phenotypic variations. Exploring the changes in transposon activity in the rice genome under space radiation is of great significance.

Methods: To analyze the activation characteristics of Ty3-retrotransposons and genetic stability of insertion sites in rice progeny after spaceflight, seeds of Nipponbare, DN416, and DN423 were exposed on board the SJ-10 recoverable satellite for 12.

Highly Dispersed Ag Nanocrystals Anchored on N-Doped Holey Carbon Aerogel as High-Mass-Loading Electrode for Cl Capture in Hybrid Capacitive Deionization.

Nanostructured Faradaic materials show extraordinary promise for capacitive deionization (CDI) toward the relief of global freshwater scarcity. But at present, there exist at least two shortages for the development of CDI electrode materials. In laboratory studies, evaluating their desalination performance is usually based on low mass loadings (<1 mg cm), which is far behind the practical demand for fabricating high-mass-loading CDI electrodes or devices.

Adaptive Switching Redundant-Mode Multi-Core System for Photovoltaic Power Generation.

As maximum power point tracking (MPPT) algorithms have developed towards multi-task intelligent computing, processors in photovoltaic power generation control systems must be capable of achieving a higher performance. However, the challenges posed by the complex environment of photovoltaic fields with regard to processor reliability cannot be overlooked. To address these issues, we proposed a novel approach.

Green Manure Rotation Combined with Biochar Application Improves Yield and Economic Stability of Continuous Cropping of Peppers in Southwest China.

Crop rotation is widely recognized as a key strategy to mitigate the adverse effects associated with continuous cropping. Recent studies have demonstrated that biochar has a significant potential for preventing and controlling these challenges. However, the ameliorative effects of green manure rotation and biochar application on continuous pepper cultivation in the karst mountainous regions of Southwest China remain largely unexplored.

Including Health System Capacities into the Assessment Framework of a Temperature-Resilience Health System.

Introduction: This study includes health system capacities into the assessment framework of a temperature-resilience health system while accounting for system interactions.

Methods: In accordance with the guidelines provided by the World Health Organization, the conceptual framework of a climate-resilient health system has been adopted. The International Health Regulations are utilized to assess the health system capacities in 171 countries from year 2011 to 2019.

Factors associated with preterm birth and mother-to-child transmission in HIV-positive pregnant women in Henan, China, 2016-2022: a retrospective cohort study.

Introduction: HIV can greatly impact the quality of life of pregnant women and may cause adverse pregnancy outcomes, such as preterm birth (PB) and mother-to-child transmission (MTCT). The purpose of this study was to analyse the influencing factors of PB and MTCT in HIV-positive pregnant women.

Methods: HIV-positive pregnant women in Henan Province between January 2016 and December 2022 were selected for the study.

Preparation and evaluation of oral insulin nanocapsule delivery systems.

Insulin therapy is essential for regulating blood sugar levels. Conventional subcutaneous injection is prone to psychological stress, local tissue damage and severe blood glucose fluctuations, and thus the development of oral insulin technology has become an alternative therapy. However, oral insulin faces challenges such as difficult absorption, poor adhesion, low bioavailability, and short duration of action, due to the large molecular weight, low permeability, and easily degradable by enzymes and gastric acids.

Hyperlipidemia and apolipoprotein E are associated with intraocular pressure of thyroid-associated ophthalmopathy in a Chinese population: a cross-sectional study.

Objective: This study aimed to explore the clinical characteristics of thyroid-associated ophthalmopathy (TAO) with hyperlipidemia and to identify the key lipid indicator.

Methods: Patients with TAO were recruited to this study and divided into two groups based on the presence of hyperlipidemia. TAO patients with hyperlipidemia were further classified based on the type of hyperlipidemia.

Exercise alleviates cognitive decline of natural aging rats by upregulating Notch-mediated autophagy signaling.

Notch signaling, a classical signaling pathway of neurogenesis, is downregulated during the aging and age-related neurodegenerative diseases. Exercise has been proposed as an effective lifestyle intervention for delaying cognitive decline. However, it remains unclear whether exercise intervention could alleviate cognitive decline by modulating neurogenesis in naturally aging rats.

Virulence phenotype alteration impacts nosocomial pathogen persistence on inanimate surfaces in hospital settings.

The hospital setting serves as a critical conduit for pathogen dissemination, particularly amid the escalating concern of nosocomial infections in China. Currently, most studies use metagenomics to investigate microbial communities in hospital settings, with less focus on the transmission strategies of individual bacteria. In our study, we identified two Klebsiella pneumoniae strains exhibiting different mucoid characteristics.

Research on Fine-Grained Phenotypic Analysis of Temporal Root Systems - Improved YoloV8seg Applied for Fine-Grained Analysis of In Situ Root Temporal Phenotypes.

Root systems are crucial organs for crops to absorb water and nutrients. Conducting phenotypic analysis on roots is of great importance. To date, methods for root system phenotypic analysis have predominantly focused on semantic segmentation, integrating phenotypic extraction software to achieve comprehensive root phenotype analysis.

Maduramicin ammonium impairs autophagic flux through activating AMPK-mediated eIF2α-ATF4 endoplasmic reticulum stress pathway in skeletal muscle.

Background: Maduramicin ammonium (MA), a widely used coccidiostat, has been reported to cause skeletal muscle degeneration in animals and even humans. In this study, we explore the underlying mechanism of its toxicity in skeletal muscle.

Results: First, we observed that MA impaired autophagic flux which was evidenced by increased protein level of LC3-II and p62 in skeletal myoblast C2C12 and L6 cell lines and rectus femoris muscle tissues of rats and broilers.

Association of systemic immune-inflammation index with all-cause and cardio-cerebrovascular mortality in individuals with diabetic kidney disease: evidence from NHANES 1999-2018.

Background: Emerging evidence suggests a potential role of immune response and inflammation in the pathogenesis of diabetic kidney disease (DKD). The systemic immune-inflammation index (SII) offers a comprehensive measure of inflammation; however, its relationship with the prognosis of DKD patients remains unclear.

Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018, this cross-sectional study involved adults diagnosed with DKD.

Diagnostic performance of simultaneous multislice diffusion-weighted imaging in differentiating breast lesions: a systematic review and meta-analysis.

Objectives: To investigate the diagnostic performance of simultaneous multislice diffusion-weighted imaging (SMS-DWI) in differentiating malignant and benign breast lesions, and compare it with conventional single shot and readout segmented echo planar imaging without the SMS technique.

Methods: The literature search was performed in PubMed, Embase, and Web of Science to identify comparative studies reporting the diagnostic performance of SMS-DWI and conventional DWI in patients with breast lesions. Histopathological analysis was used as a reference standard for malignant breast lesions.