Relationship between mindfulness and self-control in deaf individuals: mediating role of inner peace and moderating role of life experience.

Background: Self-control is essential for individual health and well-being. The relationship between mindfulness and self-control has recently become a central focus of research. However, the dynamics of this relationship in deaf and hearing individuals remain underexplored.

The Design of Hyperbranched Polymer Biguanide Molecules with a Four-Arm Branched Core Structure Enhances Antibacterial Properties.

Amide-amine (PAMAM) dendrimers are biodegradable, non-immunogenic, genotoxic, and biocompatibible, which make them excellent materials for biological applications. In order to reduce the cytotoxicity of the designed branched molecules, a four-armed branched nucleus (B4) of PAMAM dendrimers as hyperbranched molecules was fused with polyhexamethylene biguanide (PHMB) (A2); hyperbranched polymeric biguanides (PAPBs) with a four-arm central core PAMAM structure were synthesized. The bactericidal and cell toxicity tests showed that PAPB had excellent bactericidal activity against both Gram-positive bacteria and Gram-negative, and the chemical binding of PHMB and PAMAM had synergistic effects.

The impact of maternal mindful parenting on preschoolers' emotional regulation abilities: The mediating role of depression and the moderating role of the parent-child relationship.

Purpose: An examination into the effects of maternal variables on children's emotional regulation abilities, as well as the processes that underlie these effects, may improve our ability to effectively promote the development of children's emotional regulation ability. This study looks at how maternal depression influences the relationship between mindful parenting and children's emotional regulation ability. It also investigates the potential moderating effects of the parent-child relationship.

Physical Activity Correlates With Skeletal Muscle MRI Findings in Individuals With Duchenne Muscular Dystrophy.

Introduction/aims: Skeletal muscle magnetic resonance imaging (MRI) is a validated noninvasive tool to assess Duchenne muscular dystrophy (DMD) progression. There is interest in finding DMD biomarkers that decrease the burden of clinical trial participation, such as wearable devices. Our aim was to evaluate the relationship between activity, via accelerometry, and skeletal muscle MRI, particularly T mapping.

Capillary Force-Assisted CsPbBrI ( = 0, 1) Columnar Crystal Film for X-ray Detectors with Ultrahigh Electric Field and Sensitivity.

Inorganic halide perovskite thin-film X-ray detectors have attracted great research interest in recent years due to their high sensitivity, low detection limit, and facile fabrication process. The poor crystal quality of the thin film with uncontrollable thickness and low background voltage during detection limits its practical application. Here, a high-quality CsPbBrI ( = 0, 1) columnar crystal film is prepared by an improved melt-confined method with a porous anodic aluminum oxide (AAO) template, which stabilizes the disorder perovskite systems of CsPbBrI by stress.

Advanced PROTAC and Quantitative Proteomics Strategy Reveals Bax Inhibitor-1 as a Critical Target of Icaritin in Burkitt Lymphoma.

Understanding the molecular targets of natural products is crucial for elucidating their mechanisms of action, mitigating toxicity, and uncovering potential therapeutic pathways. Icaritin (ICT), a bioactive flavonoid, demonstrates significant anti-tumor activity but lacks defined molecular targets. This study employs an advanced strategy integrating proteolysis targeting chimera (PROTAC) technology with quantitative proteomics to identify ICT's key targets.

Case report: Favorable efficacy of combined afatinib and anlotinib treatment in a lung adenocarcinoma patient harboring uncommon L858M/L861R mutations.

Targeted therapy has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients carrying common mutations, but the standard care for patients with rare mutations has not been well established. Here, we report a 65-year-old female diagnosed with stage IIIC lung adenocarcinoma located in the right inferior lobe, harboring uncommon L858M/L861R mutations. Remarkably, 24 days post-treatment of afatinib and anlotinib, chest CT scans demonstrated significant shrinkage of primary lesion, indicating a partial response.

Mn, N co-doped CDs as a fluorescent nanosensing platform for the detection of tannic acid and hafnium ion and in vitro fluorescence imaging of U2OS osteosarcoma cells.

Multi-wavelength emission fluorescent manganese-nitrogen co-doped carbon dots (Mn, N co-doped CDs) were synthesized by solvothermal method using β-cyclodextrin, O-phenylenediamine, and manganese chloride as raw materials. The prepared Mn, N co-doped CDs were used as fluorescent nanosensing platforms for the detection of metal ions and biomolecules and were found to be capable of fluorescence detection of tannic acid (TA) and hafnium (Hf) ion at 320, 380, and 480 nm excitation wavelengths with multi-response linear ranges of 0.7 ~ 1.

Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin.

Background: Obstructed defecation syndrome (ODS) represents the most prevalent form of chronic constipation, affecting a diverse patient population, leading to numerous complications, and imposing a significant burden on healthcare resources. Most ODS patients have insufficient rectal propulsion, but the exact mechanism underlying the pathogenesis of ODS remains unclear.

Aim: To explore the molecular mechanism underlying the pathogenesis of ODS.

The application of immunotherapy combined with taxanes in second‑line treatment of advanced HER2 negative gastric cancer.

Human epidermal growth factor receptor-2 (HER2) negative advanced gastric cancer (GC) has a high global incidence and mortality rate with limited options for second-line treatment. Monotherapy is not effective and the combination of chemotherapy and immunotherapy has not yet been included in the guidelines. The present study aimed to explore a new treatment approach by conducting a single-center, retrospective, observational real-world study.

Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites.

Sarcopenia is a major health challenge due to an aging population. Probiotics may improve muscle function through gut-muscle axis, but their efficacy and mechanisms in treating sarcopenia remain unclear. This study investigated the impact of Bifidobacterium animalis subsp.

Ablation of LKB1 gene changes the lipid profiles of goat intramuscular fat and enhances polyunsaturated fatty acids deposition.

The content and composition of intramuscular fat (IMF) affect the cooked meat palatability such as tenderness and juiciness. Thus, elucidation of lipid deposition and its composition in goat IMF is necessary. Here, Jianzhou big-ear goats with higher IMF content is associated with lower mRNA level of LKB1 gene, compared with those of Chuannan black goats.

Ursolic Acid Inhibits Glycolysis of Ovarian Cancer via KLF5/PI3K/AKT Signaling Pathway.

Glycolysis is one of the key metabolic reprogramming characteristics of ovarian cancer. Ursolic Acid (UA), as a natural compound, exerts a beneficial regulatory effect on tumor metabolism. In this study, we have confirmed through RNA-seq analysis and a series of and functional experiments that UA significantly inhibits ovarian cancer cell proliferation, promotes tumor apoptosis, and reduces glycolysis levels.

Weakly supervised chest X-ray abnormality localization with non-linear modulation and foreground control.

Chest X-ray is widely used to diagnose lung diseases. Due to the demand for accelerating analysis and interpretation to reduce the workload of radiologists, there has been a growing interest in building automated systems of chest X-ray abnormality localization. However, fully supervised methods usually require well-trained radiologists to annotate bounding boxes manually, which is labor-intensive and time-consuming.

Surgical managements for rhegmatogenous retinal detachment: A network meta-analysis of randomized controlled trial.

Background And Objective: Rhegmatogenous retinal detachment (RRD) is the most common ophthalmic emergency threatening vision, with an incidence ranging from 6.3 to 17.9 per 100,000 people per year.

Reconsideration of the role of hydrogen peroxide in peroxymonocarbonate-based oxidation system for pollutant control.

Advanced oxidation processes that utilize peroxymonocarbonate (HCO), generated in-situ through the reaction of HCO and HO, are employed for the removal of pollutants in water. Nevertheless, the precise role of HO in these processes remains a subject of debate. This study established a HCO-based oxidation system using NaHCO and HO for the degradation of acetaminophen and investigated the activation mechanisms of coexisting oxidants.

GmTRAB1, a Basic Leucine Zipper Transcription Factor, Positively Regulates Drought Tolerance in Soybean (. L).

The basic leucine zipper (bZIP) transcription factors play crucial roles in plant resistance to environmental challenges, but the biological functions of soybean bZIP members are still unclear. In this study, a drought-related soybean bZIP gene, 1, was analyzed. The transcript of was upregulated under drought, ABA, and oxidative stresses.

Retreatment and aesthetic restoration of maxillary incisor with calcified root canal using a dynamic navigation system: a case report.

Background: Pulp canal occlusion (PCO) increases the difficulty of root canal treatment as well as tooth preservation and restoration. This is the first case report of successful localization of a calcified root canal under the guidance of a dynamic navigation system (DNS) for complete root canal retreatment and aesthetic restoration after a failed attempt to locate the calcified root canal with a traditional dental operating microscope (DOM).

Case Presentation: The patient was scheduled for root canal treatment for a labially inclined maxillary central incisor and post-core crown restoration with resin veneers in another hospital, but the calcified root canal could not be located with a microscope, so the patient was referred to our department.

Oxidative and endoplasmic reticulum stress in diabetes-related hearing loss: Protective effects of thioredoxin.

Diabetes mellitus (DM) induces complex physiological changes in the inner ear environment. This study investigates the roles of oxidative stress (OS) and endoplasmic reticulum stress (ERS) in diabetes-related hearing loss (DRHL) and explores the potential of thioredoxin (Trx) in regulating OS, ERS, and apoptosis-related factors to mitigate the progression of hearing impairment. We conducted auditory and serological assessments in 63 patients with type 2 diabetes and 30 healthy controls.

The Making of Everyday Space of Publicness: Insights from a Mall in Beijing.

The rise of malls in China raises questions about their roles as public spaces in Chinese cities. This article proposes the concept of everyday space of publicness to trace contextually sensitive ways that urban inhabitants make the mall a space for public life. The making of everyday space of publicness is evidenced using data from ethnographic fieldwork conducted in an inner-city open-air mall in Beijing.

Nitrogen source affects non-aeration microalgal-bacterial biofilm growth progression and metabolic function during greywater treatment.

The non-aeration microalgal-bacteria symbiotic system has attracted great attention due to excellent pollutants removal performance and low greenhouse gas emission. This study investigated how nitrogen (N) sources (ammonia, nitrate and urea) impact biofilm formation, pollutants removal and microbial niches in a microalgal-bacterial biofilm. Results showed that functional genus and enzymes contributed to organics biodegradation and carbon fixation, N transformation and assimilation enabled efficient pollutants removal without CO emission.

Progressive polyadenylation and m6A modification of Ighg1 mRNA maintain IgG1 antibody homeostasis in antibody-secreting cells.

Antigen-specific antibodies are generated by antibody-secreting cells (ASCs). How RNA post-transcriptional modification affects antibody homeostasis remains unclear. Here, we found that mRNA polyadenylations and N6-methyladenosine (m6A) modifications maintain IgG1 antibody production in ASCs.

Potato β-aminobutyric acid receptor IBI1 manipulates VOZ1 and VOZ2 transcription factor activity to promote disease resistance.

Upon infection with nonpathogenic microorganisms or treatment with natural or synthetic compounds, plants exhibit a more rapid and potent response to both biotic and abiotic stresses. However, the molecular mechanisms behind this phenomenon, known as defense priming, are poorly understood. β-minobutyric acid (BABA) is an endogenous stress metabolite that enhances plant tolerance to various abiotic stresses and primes plant defense responses, providing the ability to resist a variety of pathogens (broad-spectrum resistance).