Bacillus licheniformis and Wickerhamiella versatilis: Sources of the pleasant smoky and fruity flavors of soybean paste.

4-Vinylguaiacol (4-VG) and 4-Ethylguaiacol (4-EG) are key aromatic compounds that contribute to the characteristic smoky and soy-like aromas of soybean paste, thereby influencing its overall flavor. 4-EG in soybean paste reached 13.76 mg/kg through the inoculation of two bacterial strains: Bacillus licheniformis, which promotes the production of 4-VG, and Wickerhamiella versatilis, which enhances the generation of 4-EG.

Perioperative safety of simultaneous pulmonary resection and off-pump coronary artery bypass grafting: a retrospective analysis from a single institution.

Background: As an increasing number of patients with both lung cancer and coronary artery disease (CAD) are being discovered, doctors face great challenges in treating this group. Off-pump coronary artery bypass grafting (CABG) combined with simultaneous radical surgery for lung cancer has become an option at some institutions. In this study, we aimed to explore postoperative complications, hospitalization duration and expenses, and surgical safety among patients who underwent simultaneous pulmonary resection and off-pump CABG, in order to provide a new treatment approach for lung cancer patients with coronary heart disease (CHD).

Unveiling microRNA-like small RNAs implicated in the initial infection of f. sp. through small RNA sequencing.

Banana Fusarium wilt (BFW), caused by f. sp. (), poses a major challenge to the worldwide banana industry.

Impact of distal or pylorus preserving gastrectomy on postoperative quality of life in T1 stage middle third gastric cancer patients.

Pylorus-preserving gastrectomy (PPG) and distal gastrectomy (DG) are widely utilized surgical approaches for the treatment of gastric cancer. In this study, we employed questionnaire surveys and follow-up assessments to examine the effects of these surgical procedures on postoperative quality of life and pancreatic exocrine function in patients with stage T1 middle-third gastric cancer. A retrospective cohort study was conducted to analyze clinical and follow-up data from 63 gastric cancer patients who underwent distal gastrectomy and 21 who underwent pylorus-preserving gastrectomy at Nanjing University Drum Tower Hospital between January 2019 and January 2023.

OTUB1 promotes the progression of acute myeloid leukemia by regulating glycolysis via deubiquitinating c-Myc.

Acute myeloid leukemia (AML) is the most common type of adult leukemia and patients with AML often have poor prognosis, for which there remains an urgent need to identify novel selective targeted therapy. OTUB1, a deubiquitinating enzyme, is associated with the malignant progression of multiple cancers. However, the role of OTUB1 in AML is still unclear and warrants further investigations.

Exploration of membrane-active cephalosporin derivatives as potent antibacterial agents against Staphylococcus aureus biofilms and persisters.

Developing innovative antimicrobial agents is essential in the fight against drug-resistant bacteria, as well as biofilms and persistent bacteria. In this study, four series of amphiphilic cephalosporin derivatives were synthesized. Most of the compounds showed good activity against Gram-positive bacteria, among which membrane-active cephalosporin 15e showed high activity against Staphylococcus aureus.

Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial.

Background: Addressing high-salt diets in China through interventions can significantly reduce blood pressure (BP) and the associated health risks.

Objective: This study aims to evaluate the effectiveness of a comprehensive salt reduction intervention implemented across counties in Zhejiang Province, focusing on system establishment, extensive publicity, and targeted population interventions.

Methods: The Salt Reduction and Hypertension Prevention Project was initiated in Zhejiang Province.

Genome-Wide Characterization of Gibberellin Oxidase Genes () and Illustration of Their Molecular Responses to Exogenous GA in .

As key enzymes in the gibberellin (GA) biosynthesis pathway, GAoxs function as regulators of bioactive GA levels and plant architecture, yet little is understood about GAoxs in . In this study, 78 genes identified in four cotton species were divided into three subgroups: GA2ox, GA3ox, and GA20ox. Syntenic relationships of GAoxs in suggested that divergencies in gene function may be attributed to whole-genome duplication during evolution.

Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.

Overdose intake of acetaminophen (APAP) causes liver injury involving hepatic drug metabolism and activation of oxidative stress pathways, and forsythiaside A (FA) has hepatoprotective pharmacological activity, but knowledge of the mechanism of FA treatment for APAP liver injury is still lacking the literature. In this study, we investigated the effects of FA on the pregnane X receptor () by molecular docking and reporter gene assays. In addition, we explored the effects of FA on oxidative stress, endoplasmic reticulum stress (ERS), apoptosis, and hepatic pathology by interfering with in ex vivo and in vivo models.

Building a Highly Stable Red/Near Infrared Afterglow Library with Highly Branched Structures.

Achieving organic red/near infrared (NIR) phosphorescence at high temperatures is theoretically challenging because of the severe nonradiative transitions of excited triplet states with low energy gaps. This study realizes bright and persistent red/NIR afterglow with excellent high-temperature resistance up to 413 K via highly efficient (≈100%) phosphorescence resonance energy transfer (PRET) from rationally designed branched phosphorescence luminogens as energy donors to red/NIR dyes as acceptors, coupled with optimized aggregated structures. According to systematic investigations, the abundant internal cavities formed by the highly branched luminogens in solid states ensure dye loading and space limitation, which can considerably suppress nonradiative transitions at high temperatures, promoting a persistent red/NIR afterglow with excellent stability.

Smoking cessation improves health status of patients with chronic diseases: evidence from a longitudinal study of older adults in China.

Background: Smoking is a well-documented risk factor for numerous chronic diseases, and cessation is correlated with enhanced health outcomes. Nonetheless, the precise effects of smoking cessation on the health status of older adults with chronic conditions in China have not been thoroughly quantified.

Objective: This study aims to quantitatively assess the correlations between smoking cessation and enhancements in the health outcomes of elderly Chinese individuals with chronic diseases.

Fibrosis in Distal Rectum of Anorectal Malformation: A Clinicopathological Study.

Background: The distal rectum may have neuromuscular system abnormalities, which could be the causes of constipation of anorectal malformations (ARMs). This study aimed to characterize fibrosis in the distal rectum. To propose new hypotheses for the mechanism of constipation and provide histopathological evidence for the distal rectum resection during anorectoplasty.

Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis.

Accurate procentriole formation is critical for centriole duplication. However, the holistic transcriptional regulatory mechanisms underlying this process remain elusive. Here, we show that KAT7 crotonylation, facilitated by the crotonyltransferase hMOF, competes against its acetylation regulated by the deacetylase HDAC2 at the K432 residue upon DNA damage stimulation.

TEMI: Tissue Expansion Mass Spectrometry Imaging.

The spatial distribution of diverse biomolecules in multicellular organisms is essential for their physiological functions. High-throughput mapping of biomolecules is crucial for both basic and medical research, and requires high scanning speed, spatial resolution, and chemical sensitivity. Here, we developed a Tissue Expansion method compatible with matrix-assisted laser desorption/ionization Mass spectrometry Imaging (TEMI).

Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity.

Fatty acids are a primary source of carbon for Pseudomonas aeruginosa (PA) in the airways of people with cystic fibrosis (CF). Here, we use tandem mass-tag proteomics to analyse the protein expression profile of a CF clinical isolate grown on different fatty acids. Two fatty acyl-CoA dehydrogenases (designated FadE1 and FadE2) are strongly induced during growth on fatty acids.

Magnolol protects C6 glioma cells against neurotoxicity of FB1 via modulating PI3K/Akt and mitochondria-associated apoptosis signaling pathways.

Fumonisin B1 (FB1) is a contaminant commonly occurring in crops and food. Mycotoxin contamination, including FB1, has been progressively shown to be an important risk factor in mediating neurotoxicity and neurodegenerative diseases. Studies have found that magnolol (MAG) exhibits favorable pharmacological effects in the central nervous system.

Search for MeV-Scale Axionlike Particles and Dark Photons with PandaX-4T.

Axionlike particles (ALPs) and dark photons (DPs) are viable dark matter particle candidates. We have searched for possible ALP/DP signals in the PandaX-4T liquid xenon detector using 440  kg·yr of data. A binned likelihood fit is constructed to search for possible mono-energetic peaks induced by the absorption processes between ALPs/DPs and atomic electrons of xenon.

The hidden interplay between sex and adverse outcomes in incident dialysis patients: the role of aortic calcification.

Background: Research on the sex disparity in the prognosis of chronic kidney disease (CKD), particularly among those who are newly initiating dialysis, is limited and inconclusive. This study aimed to investigate the associations between sex, and all-cause mortality and major cardiovascular adverse events (MACE), with a particular focus on the presence of aortic calcification (AC).

Methods: We conducted a analysis of 1459 incident dialysis patients included in this prospective cohort study.

Sleep Duration, Sleep Habits, and Social Jetlag From 4 to 6 years Their Impacts on Myopia Among School-Aged Children: The Ma'anshan Birth Cohort Study.

Purpose: To examine the associations of sleep parameters and their trajectories at preschool age with myopia among school-aged children by using a birth cohort study design.

Patients And Methods: All participants were recruited from the Ma'anshan Birth Cohort Study. Sleep duration, sleep habits, and social jetlag were collected in 4 years, 5.

Graphene Nanoribbon Core Thermotropic Liquid Crystal with A Well-Defined Molecular Structure.

Graphene nanoribbons (GNRs) with hierarchical and well-ordered structures are believed to deliver superior performance in semiconductor device applications. Despite this potential, traditional alignment techniques for GNRs often fall short in producing defect-free and precisely defined molecular architectures. Here, we introduce a strategy for the fabrication of highly-ordered GNRs by empowering them with thermotropic liquid crystallinity, utilizing a bottom-up solution synthesis approach.

Integrating short-read and long-read single-cell RNA sequencing for comprehensive transcriptome profiling in mouse retina.

The vast majority of protein-coding genes in the human genome produce multiple mRNA isoforms through alternative splicing, significantly enhancing the complexity of the transcriptome and proteome. To establish an efficient method for characterizing transcript isoforms within tissue samples, we conducted a systematic comparison between single-cell long-read and conventional short-read RNA sequencing techniques. The transcriptome of approximately 30,000 mouse retina cells was profiled using 1.

Mn loading on montmorillonite surfaces for Cd stabilization: Insights from density functional theory calculations and surface complexation modeling.

The latest works have been devoted to the stabilization mensuration for heavy metals and indicate that clay minerals can promote Cd(II) precipitation by favoring the retention of Mn(II). The assessment however has been tempered due to lacking the information about the molecular-level surface complexation structure and Cd nucleation process on clay surfaces. In this study, microscopic mechanisms for adsorption and stabilization of Cd at montmorillonite interfaces with or without Mn loading were leveraged by combining surface complexation model (SCM) evaluations and density functional theory (DFT) calculations.

Deficiency of DDI2 suppresses liver cancer progression by worsening cell survival conditions.

The levels of reactive oxygen species (ROS) and the extent of ensuing DNA damage significantly influence cancer initiation and progression. Of crucial importance, the aspartate protease DDI2 has been proposed to play a pivotal role in monitoring intracellular ROS levels (to trigger oxidative eustress or distress), as well as in the oxidative DNA damage repair, through redox homeostasis-determining factor Nrf1 (encoded by NFE2L1). However, the specific role of DDI2 in the multi-step process resulting in the development and progression of liver cancer remains elusive to date.

Midkine, a novel MCP-1 activator mediated PM2.5-aggravated experimental pulmonary fibrosis.

Exposure to fine particulate matter (PM2.5) is associated with increased morbidity and mortality among patients with idiopathic pulmonary fibrosis (IPF). Pathological alterations in IPF typically originate in the subpleural regions of the lungs.