Factors Associated With Digital Capacity for Health Promotion Among Primary Care Workers: Cross-Sectional Survey Study.

Background: Health education and promotion are recognized as effective strategies for fostering healthy ageing, reducing the disease burden, and addressing health inequalities, particularly when delivered through digital media. Primary care workers are often regarded as the key providers of these interventions. Despite the strong practical significance and substantial individual demand, the use of digital media for delivering health promotion practices was not widespread in China.

Co-In Bimetallic Hydroxide Nanosheet Arrays With Coexisting Hydroxyl and Metal Vacancies Anchored on Rod-Like MOF Template for Enhanced Photocatalytic CO Reduction.

Layered double hydroxides (LDHs) can serves as catalysts for CO photocatalytic reduction (COPR). However, the conventionally synthesized LDHs undergo undesired aggregation, which results in an insufficient number of active sites and limits the desirable electron transfer required for COPR. The metal-organic framework (MOF) template-grown LDHs demonstrate excellent promise for exploiting the strengths of both MOFs and LDHs.

Refining Metal-Free Carbon Nanoreactors through Electronic and Geometric Comodification for Boosted HO Electrosynthesis toward Efficient Water Decontamination.

Hydrogen peroxide (HO) electrosynthesis using metal-free carbon materials via the 2e oxygen reduction pathway has sparked considerable research interest. However, the scalable preparation of carbon electrocatalysts to achieve satisfactory HO yield in acidic media remains a grand challenge. Here, we present the design of a carbon nanoreactor series that integrates precise O/N codoping alongside well-regulated geometric structures targeting high-efficiency electrosynthesis of HO.

Pharmacokinetics and Bioequivalence Evaluation of Trazodone Hydrochloride Sustained-Release Tablets in Healthy Chinese Volunteers.

The aim of this study was to investigate the pharmacokinetics, bioequivalence, and safety of generic trazodone hydrochloride sustained-release tablet and its reference listed product in healthy Chinese subjects. An open, randomized, single-dose, and 2-period crossover study was involved under fasting and fed conditions, with a 7-day washout period. A single oral dose of 150 mg of 2 trazodone hydrochloride sustained-release tablets was administered to 84 healthy volunteers, with 36 in the fasting group and 48 consuming a high-fat diet, respectively.

TRPM8 and TRPA1 ideal targets for treating cold-induced pain.

TRP channels are essential for detecting variations in external temperature and are ubiquitously expressed in both the peripheral and central nervous systems as integral channel proteins. They primarily mediate a range of sensory responses, including thermal sensations, nociception, mechanosensation, vision, and gustation, thus playing a critical role in regulating various physiological functions. In colder climates, individuals often experience pain associated with low temperatures, leading to significant discomfort.

Direct parallel electrosynthesis of high-value chemicals from atmospheric components on symmetry-breaking indium sites.

To tackle significant environmental and energy challenges from increased greenhouse gas emissions in the atmosphere, we propose a method that synergistically combines cost-efficient integrated systems with parallel catalysis to produce high-value chemicals from CO, NO, and other gases. We employed asymmetrically stretched InOS with symmetry-breaking indium sites as a highly efficient trifunctional catalysts for NO reduction, CO reduction, and O reduction. Mechanistic studies reveal that the symmetry-breaking at indium sites substantially improves d-band center interactions and adsorption of intermediates, thereby enhancing trifunctional catalytic activity.

MOF-confined ultrafine nanozymes with enhanced catalysis for sensitive colorimetric detection of glucose.

The constrained enzymatic activity and aggregation challenges encountered of nanozymes pose an obstacle to their practical utility, necessitating a strategy to alleviate this problem and improve the enzymatic catalytic efficiency. Herein, MOF-confined ultrafine ZnIrO clusters (ZnIrO/ZnIrMOFs) nanozyme have been synthesized by controlling the in-situ growth of ZnIrO via a one-pot method. Notably, due to the domain-limiting effect of MOF, the ZnIrO clusters with small size grew uniformly in the structure of ZnIrMOFs nanosheets, while the presence of Zn atoms improved the crystallinity of the MOF phase and the dispersion of ZnIrO clusters.

Lithium isotope evidence for a plumeworld ocean in the aftermath of the Marinoan snowball Earth.

The snowball Earth hypothesis predicts that continental chemical weathering diminished substantially during, but rebounded strongly after, the Marinoan ice age some 635 Mya. Defrosting the planet would result in a plume of fresh glacial meltwater with a different chemical composition from underlying hypersaline seawater, generating both vertical and lateral salinity gradients. Here, we test the plumeworld hypothesis using lithium isotope compositions in the Ediacaran Doushantuo cap dolostone that accumulated in the aftermath of the Marinoan snowball Earth along a proximal-distal (nearshore-offshore) transect in South China.

Incorporating platelet-to-white blood cell ratio into survival prediction models for intracerebral hemorrhage: a nomogram approach.

Background: Predicting long-term survival in intensive care unit patients with intracerebral hemorrhage (ICH) is crucial. This study aimed to develop a platelet-to-white blood cell ratio (PWR) incorporated nomogram for long-term survival prediction.

Methods: A retrospective analysis was conducted on 1,728 ICH patients in the MIMIC-IV 2.

Safety and efficacy of intravitreal dexamethasone implantation along with phacoemulsification and intraocular lens implantation in children with uveitis.

Purpose: To evaluate the safety and efficacy of intravitreal dexamethasone implantation during phacoemulsification and intraocular lens implantation in pediatric uveitis.

Methods: A retrospective analysis was conducted on pediatric uveitis patients undergoing phacoemulsification and intraocular lens implantation with intravitreal dexamethasone implantation. Patients with a minimum follow-up of 6 months were included.

The role of ferroptosis resistance in lymph-associated tumour metastasis.

Tumour metastasis is a crucial factor in determining clinically challenging tumours. In this respect, the lymphatic system may act as potential entry portals for tumour metastasis, whilst, clinical detection of tumour-infiltrated lymph nodes also indicates poorer prognosis and higher metastatic risk. Whether tumour cells gain ferroptosis resistance in lymph that make them exhibit a stronger propensity for lymphatic dissemination compared to hematogenous spread might be a breakthrough for elucidating lymph-associated tumour metastasis.

The associations between modifiable risk factors and constipation: a comprehensive mendelian randomization study.

Objective: Early identification of modifiable risk factors is crucial for the prevention of constipation. This study systematically investigated the relationship between genetically predicted modifiable risk factors and constipation.

Methods: The inverse variance weighting (IVW) method was employed as the primary analytical approach.

Graphene Chainmail-Enabled Moderate Precatalyst Phase Evolution for Sustainable Polysulfide Electrocatalysis in Li─S Batteries.

The rational design of polysulfide electrocatalysts is of vital importance to achieve longevous Li─S batteries. Notwithstanding fruitful advances made in elevating electrocatalytic activity, efforts to regulate precatalyst phase evolution and protect active sites are still lacking. Herein, an in situ graphene-encapsulated bimetallic model catalyst (CoNi@G) is developed for striking a balance between electrocatalytic activity and stability for sulfur electrochemistry.

Biofunctionalized dissolvable hydrogel microbeads enable efficient characterization of native protein complexes.

The characterization of protein complex is vital for unraveling biological mechanisms in various life processes. Despite advancements in biophysical tools, the capture of non-covalent complexes and deciphering of their biochemical composition continue to present challenges for low-input samples. Here we introduce SNAP-MS, a Stationary-phase-dissolvable Native Affinity Purification and Mass Spectrometric characterization strategy.

Real-time analysis of the biomolecular interaction between gelsolin and Aβ monomer and its implication for Alzheimer's disease.

Biomolecular interaction acts a pivotal part in understanding the mechanisms underlying the development of Alzheimer's disease (AD). Herein, we built a biosensing platform to explore the interaction between gelsolin (GSN) and different β-amyloid protein 1-42 (Aβ) species, including Aβ monomer (m-Aβ), Aβ oligomers with both low and high levels of aggregation (LLo-Aβ and HLo-Aβ) via dual polarization interferometry (DPI). Real-time molecular interaction process and kinetic analysis showed that m-Aβ had the strongest affinity and specificity with GSN compared with LLo-Aβ and HLo-Aβ.

Main-Group Metal-Nonmetal Dynamic Proton Bridges Enhance Ammonia Electrosynthesis.

The electrochemical nitrogen reduction reaction (eNRR) is a crucial process for the sustainable production of ammonia (NH) for energy and agriculture applications. However, the reaction's efficiency is highly dependent on the activation of the inert N≡N bond, which is hindered by the electron back-donation to the π* orbitals of the N≡N bond, resulting in low eNRR capacity. Herein, we report a main-group metal-nonmetal (O-In-S) eNRR catalyst featuring a dynamic proton bridge, with In-S serving as the polarization pair and O functioning as the dynamic electron pool.

Comprehensive Screening and Characterization of α-glucosidase Inhibitory Components in the Edible Medicinal Plant Pholidota cantonensis Rolfe Using UPLC-Q-TOF-MS/MS Analysis and Molecular Docking.

Pholidota cantonensis Rolfe is an edible medicinal plant in the genus Pholidota of the family Orchidaceae. This plant is used to prepare medicated food in China and has been reported to possess anti-α-glucosidase activity. To date, little is known about the active substances responsible for the observed anti-α-glucosidase activity.

Dip2a regulates stress susceptibility in the basolateral amygdala.

JOURNAL/nrgr/04.03/01300535-202506000-00025/figure1/v/2024-08-05T133530Z/r/image-tiff Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post-traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters.

Epithelial-mesenchymal plasticity in cancer: signaling pathways and therapeutic targets.

Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial-mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial-mesenchymal transition (EMT), partial EMT, and mesenchymal-epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via transcriptional regulation and a series of signaling pathways, including transforming growth factor-β, Wnt/β-catenin, and Notch.