Epileptic Encephalopathy Mutation Displays a Loss-of-Function Phenotype and Distinct Insensitivity to Valproate.

Voltage-gated sodium channels are the main targets of antiepileptic drugs, such as sodium valproate (VPA). Single nucleotide polymorphisms (SNPs) in the Nav1.6 isoform () have been reported to be closely associated with motor dysfunction in pediatric akathisia epileptica.

Enhancing coastal ecosystem resilience amid transboundary marine pollution through collaborative governance: An evolutionary game analysis.

The loss of coastal ecosystem resilience caused by protracted marine pollution has prompted local governments (LGs) to govern marine pollution, yet the transboundary nature of marine pollution represents a challenge for collaborative governance action among LGs. This paper employs evolutionary game theory to examine the evolutionary stable strategies of LGs with or without the supervision of the central government (CG). The result shows that LGs choosing collaborative governance and CG choosing passive supervision are the optimal evolutionary stability strategies.

Targeting regulation of lipid metabolism with polysaccharide of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease: A review.

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic diseases in the world, and the effective treatment of NAFLD has been listed as a key problem to be solved urgently in contemporary medicine. Polysaccharides in traditional Chinese medicine (TCM) have a wide range of pharmacological activities. A large number of preclinical studies have confirmed that TCM polysaccharides can interfere with the occurrence and development of NAFLD at multiple interrelated levels, such as improving lipid metabolism and insulin resistance, regulating oxidative stress, alleviating immune inflammatory response, and regulating intestinal microbiota, thus showing great potential as a new anti-NAFLD drug.

A self-powered PFC sensing platform via integrating aptamer-modified photoanode and Z-scheme signal amplifying photocathode for microcystin-LR detection.

Background: Microcystin-LR (MC-LR) is a hepatotoxin produced by cyanobacteria, which is biologically toxic, prevalent, and has serious effects on human health. Therefore, it is urgent to develop miniaturized and cost-efficient methods for MC-LR monitoring. Photocatalytic fuel cell (PFC) sensing has already been tipped as a promising approach for facile, on-site detection in environmental mediators.

Isolation, Genomic Characterization, and Immunogenicity Evaluation of a G9P[23] Porcine Rotavirus Strain.

(1) Background: Rotavirus (RV) is the primary pathogen causing diarrhea in infants and young children. The G9-type is an emerging genotype; however, its isolation is challenging, and its immunogenicity to piglets is poorly understood. This study aimed to isolate, characterize, and evaluate the immunogenicity of a PoRVA strain, RHeN2, obtained from the diarrhea samples of piglets from a pig farm in Henan Province, China.

Inhibitory Effect and Mechanism of Dryocrassin ABBA Against .

Potato dry rot and wilt are the most important soil- and seed-borne diseases in potatoes. They cause high economic losses during potato growth and storage across the world. Previous observations have shown that dryocrassin ABBA can induce resistance in potatoes.

Targeting ferroptosis in the treatment of ulcerative colitis by traditional Chinese medicine: A novel therapeutic strategies.

Background: The incidence of ulcerative colitis (UC) has been rising rapidly in recent years, and there is currently no effective method to prevent its recurrence. Owing to its long treatment duration, difficulty in treatment, prolonged remission, and high costs, it has attracted global attention. Exploring safe, effective, and sustainable treatment regimens has become an urgent global issue.

Enhancing lipase enzymatic performance with dynamic covalent dextran-based hydrogels.

How to maintain high catalytic activity and stability in the process of biocatalysis is crucial, inspiring strategies to construct an appropriate immobilized hydrogel system. Inspired by biologically relevant interactions of natural polymers, we crafted a polysaccharide-based dynamic hydrogel through imine bonds among lipase, oxidized dextrans (ODex) and carboxymethylchitosan. The successful preparation of ODex and the in situ immobilization of lipase through a Schiff base reaction were verified by FT-IR, H NMR, XRD, and the hydroxylamine hydrochloride method.

Effects of doping on anti-phase boundaries and the magnetic properties of the D0 structure in high silicon steel: first-principles insights.

The D0 ordered structure is crucial for the room-temperature plasticity of high silicon steel. The formation of anti-phase boundaries (APBs) due to dislocation movement in the ordered structures hinders subsequent dislocation motion, leading to embrittlement. A low anti-phase boundary energy () can facilitate dislocation slip and enhance the plastic deformation capability of the ordered structures.

Rh-Catalyzed Formal [3 + 2] Cycloaddition Reactions with Cyclopropenones via Sequential C-H/C-C Bond Activation.

The utilization of high-valent metal catalysts to promote cycloaddition reactions involving π bonds through C-C bond activation remains challenging. Despite extensive research, the cycloaddition of aldehydes with cyclopropenones catalyzed by metal complexes has not been documented. Herein, we disclose a novel Rh(III)-catalyzed cycloaddition reaction between cyclopropenones and aldehydes, enabling the efficient synthesis of highly functionalized furanones.

SECTM1 acts as an immune-related biomarker of poor prognosis and promotes cancer progression by modulating M2 macrophage polarization in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is the most prevalent primary malignant esophageal tumor in China and has a poor prognosis, but lacks effective diagnostic and prognostic biomarkers. Through single-sample gene set enrichment analysis (ssGSEA), we conducted immune genomic analysis based on 28 immune features using transcriptomic data from 155 ESCC cases. We established of two ESCC subtypes characterized by high and low immune profiles, and 352 differentially expressed immune genes were identified between the two subtypes.

BXM2 Treatment Alleviates Disorders Induced by a High-Fat Diet in Mice by Improving Intestinal Health and Modulating the Gut Microbiota.

BXM2 is a novel probiotic derived from fermented passion fruit () juice that possesses promising probiotic potential. The aim of this study was to evaluate the beneficial effects of BXM2 supplementation in mice. BXM2 was orally administered to male SPF C57BL/6J mice fed a high-fat diet (HFD) to evaluate its anti-obesity potential, as well as the effects on intestinal health and microbiota.

Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy.

Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications for predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) that accurately recapitulates the cellular and molecular pathology of human brain tumors. Patient-derived tumor explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling culture of a wide range of human tumors in the central nervous system (CNS), including adult, pediatric, and metastatic brain cancers.

Prediction of High-risk Capsule Characteristics for Recurrence of Pleomorphic Adenoma in the Parotid Gland Based on Habitat Imaging and Peritumoral Radiomics: A Two-center Study.

Rationale And Objectives: This study aims to develop and validate an ultrasoundbased habitat imaging and peritumoral radiomics model for predicting high-risk capsule characteristics for recurrence of pleomorphic adenoma (PA) of the parotid gland while also exploring the optimal range of peritumoral region.

Materials And Methods: Retrospective analysis was conducted on 325 patients (171 in training set, 74 in validation set and 80 in testing set) diagnosed with PA at two medical centers. Univariate and multivariate logistic regression analyses were performed to identify clinical risk factors.

Life's Essential 8 and Risk of All-Cause and Cardiovascular Mortality in US Adults With Arthritis: A Retrospective Cohort Study Utilizing NHANES Database.

Background: Life's Essential 8 (LE8) is a recently updated algorithm for evaluating cardiovascular health (CVH). This study investigates the association between LE8 and mortality risk among individuals with arthritis in the United States.

Methods: We conducted a retrospective cohort study using data from the US National Health and Nutritional Examination Survey (NHANES) 2005-2018.

Role of aspirin in cancer prevention.

Aspirin [1], also known as acetylsalicylic acid, is a common non-steroidal anti-inflammatory drug (NSAID). The available evidence shows that aspirin can effectively prevent and treat diseases such as rectal, gastric, ovarian, prostate, and lung cancer. Aspirin has been extensively studied for the prevention and treatment of colorectal cancer.

Physical-aware model accuracy estimation for protein complex using deep learning method.

With the breakthrough of AlphaFold2 on monomers, the research focus of structure prediction has shifted to protein complexes, driving the continued development of new methods for multimer structure prediction. Therefore, it is crucial to accurately estimate quality scores for the multimer model independent of the used prediction methods. In this work, we propose a physical-aware deep learning method, DeepUMQA-PA, to evaluate the residue-wise quality of protein complex models.

Metal-halide porous framework superlattices.

The construction of superlattices with a spatial modulation of chemical compositions allows for the creation of artificial materials with tailorable periodic potential landscapes and tunable electronic and optical properties. Conventional semiconductor superlattices with designable potential modulation in one dimension has enabled high-electron-mobility transistors and quantum-cascade lasers. More recently, a diverse set of superlattices has been constructed through self-assembly or guided assembly of multiscale building units, including zero-dimensional nanoclusters and nanoparticles, one-dimensional nanorods and nanowires, two-dimensional nanolayers and nanosheets, and hybrid two-dimensional molecular assemblies.

Chitosan hydrochloride coated and nonionic surfactant modified niosomes: a better way for oral administration of semaglutide.

Diabetes is now a global chronic disease, with the number of people with diabetes expected to reach 643 million by the end of 2030. Semaglutide, a human glucagon-like peptide-1 (GLP-1) analogue with 94% similarity to human GLP-1, can promote insulin secretion and repress glucagon secretion in a glucose concentration-dependent manner, resulting in substantial improvement of blood glucose levels and reducing the risk of hypoglycemia in patients with type 2 diabetes. To improve the absorption efficiency of semaglutide in oral delivery, we developed chitosan hydrochloride-coated and nonionic surfactant-modified niosomes (CS.

Impact of cascade reservoir on the sources of organic matter in sediments of Lancang river.

The construction of dams to intercept natural rivers constitutes the most severe human activity influencing the underlying surface. This study focuses on four cascade reservoirs of the Lancang River and explores their impact on the migration of organic matter in sediments. The research reveals significant spatial variations in total organic carbon (TOC) and total nitrogen concentrations in the sediments of the four reservoirs.

Association between ethylene oxide exposure and cognitive function in older adults from NHANES data.

Ethylene Oxide (EO), a volatile organic compound, has garnered considerable attention for its potential impact on human health. Yet, the ramifications of EO exposure on the cognitive functionality of the elderly remain unclear. The aim of this study is to determine whether EO exposure in the elderly correlates with cognitive function.

Anti-Fatigue Activity of Corn Protein Hydrolysate Fermented by Lactic Acid Bacteria.

Objectives: This study aimed to clarify the effect of lactic acid bacteria-fermented corn protein hydrolysate (FCH) on fatigue in mice and explore the connection between fatigue-related indicators and intestinal microbial flora.

Methods: The fatigue model of mice was constructed by exercise endurance experiment. The anti-fatigue level of FCH was evaluated by measuring physiological and biochemical indexes in mouse serum, liver and skeletal muscle.

Bioprospecting of a Native Plant Growth-Promoting Bacterium B6 for Enhancing Uranium Accumulation by Sudan Grass ( (Piper) Stapf).

Phytoremediation technology is viewed as a potential solution for addressing soil uranium contamination. Sudan grass ( (Piper) Stapf.), noted for its robust root structure and resilience to heavy metals, has garnered significant attention.

Ephrin A1 functions as a ligand of EGFR to promote EMT and metastasis in gastric cancer.

Distant metastasis is the major cause of gastric cancer mortality, and epidermal growth factor receptor (EGFR) activation plays critical roles in gastric cancer dissemination. However, EGFR targeting therapies in gastric cancer show only marginal effects, and the molecular mechanisms of oncogenic EGFR signaling remain poorly defined. Here, we report Ephrin A1 as a novel ligand of EGFR in gastric cancer.