Identification biomarkers and therapeutic targets of disulfidptosis-related in rheumatoid arthritis via bioinformatics, molecular dynamics simulation, and experimental validation.

The relationship between disulfidptosis and rheumatoid arthritis (RA) remains unclear. We aimed to identified biomarkers disulfidptosis-related in RA and revealed potential targeted drugs. Two microarray datasets (GSE93272, GSE45291) related to RA were downloaded from the Gene Expression Omnibus (GEO) database.

An All-in-One Testing Chip for the Simultaneous Measurement of Multiple Thermoelectric Parameters in Doped Polysilicon.

Polysilicon is widely used as a thermoelectric material due to its CMOS compatibility and tunability through doping. The accurate measurement of the thermoelectric parameters-such as the Seebeck coefficient, thermal conductivity, and electrical resistivity-of polysilicon with various doping conditions is essential for designing and fabricating high-performance thermopile sensors. This work presents an all-in-one testing chip that incorporates double-layer thermoelectric structures on a suspended membrane-based supporting layer, with polysilicon constituting at least one of these thermoelectric layers.

Chromosome-scale haploid genome assembly of Durio zibethinus KanYao.

Durian (Durio zibethinus) is a tropical fruit valued for its nutritional and commercial significance. In this study, we generated two high-quality, haplotype-resolved, chromosome-level genomes of the durian cultivar 'Kan Yao', each with 28 chromosomes. The total genome lengths were 737.

Room-Temperature Amplified Spontaneous Emission in Two-Dimensional WS_{2} beyond Exciton Mott Transition.

The highly excited electron-hole plasma (EHP) phase is a natural platform for studying amplified spontaneous emission (ASE), yet research into the many-body physics of EHP and ASE in two-dimensional (2D) semiconductors remains limited. Here, we report the first observation of ASE from EHP in 2D semiconductors, evidenced by an unusually sharp enhancement of emissions in suspended bilayer WS_{2} at a threshold power, confirming the transient differential transmission measurements under continuous wave excitations. We modeled the optical dielectric response of varying densities of excited carriers and accurately reproduced the observed emission features across different electron-hole phases from bilayer WS_{2} over a simple Fabry-Pérot cavity.

LXA4 alleviates inflammation and ferroptosis in cigarette smoke induced chronic obstructive pulmonary disease via the ALX/FPR2 receptor.

Ferroptosis, a form of regulated cell death, is closely related to the development of chronic obstructive pulmonary disease (COPD). Lipoxin A4 (LXA4) has garnered attention due to its well-established anti-inflammatory and antioxidant properties. However, whether its role in COPD is associated with the inhibition of ferroptosis is unknown.

Phytochemicals from fractioned dark tea water extract enhance the digestive enzyme inhibition, antioxidant capacities and glucose-lipid balance.

Dark tea has long been recognized for its health-promoting benefits, attributed to its complex phytochemical composition. However, the specific bioactive compounds responsible for these beneficial effects remain inadequately characterized. This study aimed to explore the impact of dark tea water extract (DTE) on digestive enzyme activity, antioxidant capacity, and glucose-lipid balance.

An intelligent humidity sensing system for human behavior recognition.

An intelligent humidity sensing system has been developed for real-time monitoring of human behaviors through respiration detection. The key component of this system is a humidity sensor that integrates a thermistor and a micro-heater. This sensor employs porous nanoforests as its sensing material, achieving a sensitivity of 0.

Electrochemical Leaching of Cobalt from Cobaltite: Box-Behnken Design and Optimization with Response Surface Methodology.

Cobalt, a critical metal, is anticipated to increase in market demand in the next couple of decades, particularly as a battery material used in electric vehicle application. To boost the domestic production of cobalt in the United States, an electrochemical process has been developed to recover cobalt from a cobaltite-rich concentrate and produce cobalt- and arsenic-rich leachate. The leaching efficiency of cobalt was optimized with a response surface methodology by modifying the electrochemical parameters.

Effects of pristine and photoaged tire wear particles and their leachable additives on key nitrogen removal processes and nitrous oxide accumulation in estuarine sediments.

Despite growing attention to the environmental pollution caused by tire wear particles (TWPs), the effects of pristine and photoaged TWPs (P-TWPs and A-TWPs) and their TWP leachates (TWPLs; P-TWPL and A-TWPL) on key nitrogen removal processes in estuarine sediments remain unclear. This study explores the responses of the denitrification rate, anammox rate, and nitrous oxide (NO) accumulation to P-TWP, A-TWP, P-TWPL, and A-TWPL exposure in estuarine sediments, and assesses the potential biotoxic substances present in TWPLs. P-TWPs reduced the denitrification rate by 17.

SNHG16 alleviates pulmonary ischemia-reperfusion injury by promoting the Warburg effect through regulating MTCH2 expression: experimental studies.

Background: Pulmonary ischemia-reperfusion injury (PIRI) is a major cause of fatality post-lung transplantation. Though some long non-coding RNAs (lncRNAs) have been studied in acute lung injury (ALI), their effects on PIRI remain undefined. The present study aims to explore the underlying mechanism of small nucleolar RNA host gene 16 (SNHG16) in PIRI.

Protective effects of tissue factor pathway inhibitor on mice with lipopolysaccharide-induced acute lung injury.

Acute lung injury (ALI) resulting from bacterial infection poses a significant risk, and its etiology involves the complex interplay of harmful immune responses and blood coagulation. Despite this understanding, the roles and mechanisms of tissue factor pathway inhibitor (TFPI) in LPS-induced ALI remain insufficiently elucidated. In this study, we aimed to explore the effects of TFPI in LPS-induced ALI.

[Visualization analysis of predictive model of acute kidney injury in patients with sepsis by online dynamic nomogram: research on development and validation of application].

Objective: To explore the risk factors of septic acute kidney injury (sAKI) in patients with sepsis, construct a predictive model for sAKI, verify the predictive value of the model, and develop a dynamic nomogram to help clinical doctors identify patients with high-risk sAKI earlier and more easily.

Methods: A cross-sectional study was conducted. A total of 245 patients with sepsis admitted to intensive care unit (ICU) of the Affiliated Hospital of Jining Medical University from May 2013 to November 2023 were enrolled as the research subjects.

Analysis of therapeutic effects and influencing factors of ICIs in lung-cancer patients.

Objective: The aim of this retrospective study was to analyze the efficacy and risk factors of immune checkpoint inhibitors (ICIs) in lung cancer patients.

Methods: One hundred lung cancer patients who were treated in our hospital from May 2021 to May 2023 were selected as the study subjects and divided into chemotherapy group (n = 50) and ICIs group (n = 50), in which the chemotherapy group was given the combined treatment of vincristine and cisplatin (NP), while the ICIs group was given ICIs for treatment. The therapeutic effect and adverse reactions (hypertriglyceridemia, anemia, hypertension and hypoproteinemia) of the two groups were compared, and fasting venous blood was collected.

Evaluation of a non-nucleoside inhibitor of the RSV RNA-dependent RNA polymerase in translatable animals models.

Respiratory Syncytial Virus (RSV) causes severe respiratory infections and concomitant disease resulting in significant morbidity and mortality in infants, elderly, and immunocompromised adults. Vaccines, monoclonal antibodies, and small-molecule antivirals are now either available or in development to prevent and treat RSV infections. Although rodent and non-rodent preclinical animal models have been used to evaluate these emerging agents, there is still a need to improve our understanding of the pharmacokinetic (PK)-pharmacodynamic (PD) relationships within and between animal models to enable better design of human challenge studies and clinical trials.

High sensitivity measurement of ULF, VLF, and LF fields with a Rydberg-atom sensor.

Fields with frequencies below megahertz are challenging for Rydberg-atom-based measurements, due to the low-frequency electric field screening effect caused by the alkali-metal atoms adsorbed on the inner surface of the container. In this paper, we investigate electric field measurements in the ultralow frequency (ULF), very low frequency (VLF), and low frequency (LF) bands in a Cs vapor cell with built-in parallel electrodes. With optimization of the applied DC field, we achieve high-sensitive detection of the electric field at frequencies of 1 kHz, 10 kHz, and 100 kHz based on the Rydberg-atom sensor, with the minimum electric field strength down to 18.

Enhancing long-term frequency stability of an actively mode-locked optoelectronic oscillator via a phase-locked loop.

A method to improve the frequency stability of microwave frequency comb (MFC) signals generated by an actively mode-locked optoelectronic oscillator (AML-OEO) is proposed and experimentally demonstrated. In the experiment, fundamental mode locking in the constructed AML-OEO is achieved, producing MFC signals with a center frequency of 2.165 GHz and a repetition rate of 396.

Customizing Ionic Liquids Functionalized MOFs Composites with Hydrophobic Interface for Electrochemical CO Reduction.

The electrochemical carbon dioxide reduction reaction (CORR) to generate feedstocks for chemical products (e.g., carbon monoxide, CO) offers a highly attractive method for achieving the closure of the carbon cycle.

Effect of lipid type on betulin-stabilized water-in-oil Pickering emulsion: emulsion properties, in vitro digestion, and betulin bioaccessibility.

Background: The Pickering emulsion delivery technique is widely acknowledged for its efficacy in serving as a carrier that can encapsulate functional components effectively. Previous studies have shown significant differences in the stability of Pickering emulsions composed of different oil phases and in the bioaccessibility of the encapsulated functional ingredients. This study therefore investigated the effects of different carrier oils in the betulin self-stabilized water-in-oil (W/O) Pickering emulsion on the stability of the emulsion and bioaccessibility of betulin.

Identification of diagnostic biomarkers and immune cell infiltration in tongue squamous cell carcinoma using bioinformatic approaches.

Objective: In this study, we employed a bioinformatics approach to identify diagnostic biomarkers for tongue squamous cell carcinoma (TSCC) and investigate the infiltration of immune cells in TSCC, as well as the relationship between biomarkers and immune cells.

Methods: We obtained the TSCC expression dataset from a database and conducted differential gene expression analysis between TSCC and adjacent normal tissues using R software. Enrichment analysis of the differentially expressed genes (DEGs) was performed using the DAVID website.

Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.

Herpesvirus infections are ubiquitous, with over 95% of the adult population infected by at least one strain. While most of these infections resolve without treatment in healthy individuals, they can cause significant morbidity and mortality in immunocompromised, stem cell, or organ transplant patients. Current nucleoside standards of care provide meaningful benefit but are limited due to poor tolerability, resistance, and generally narrow spectrum of activity.

Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects.

Critical size bone defects represent a significant challenge worldwide, often leading to persistent pain and physical disability that profoundly impact patients' quality of life and mental well-being. To address the intricate and complex repair processes involved in these defects, we performed single-cell RNA sequencing and revealed notable shifts in cellular populations within regenerative tissue. Specifically, we observed a decrease in progenitor lineage cells and endothelial cells, coupled with an increase in fibrotic lineage cells and pro-inflammatory cells within regenerative tissue.

Enhanced bioaccessibility of interfacial delivered oleanolic acid through self-constructed Pickering emulsion: Effects of oil types.

Pentacyclic triterpenes have attracted much attention because of their many bioactivities, but their bioaccessibility is low. Oleanolic acid (OA) was used in this study as a typical edible pentacyclic triterpene. In this work, we proposed an OA interfacial delivery model based on W/O Pickering emulsion, and investigated the effects of different oil types on the emulsion properties and OA bioaccessibility of the OA W/O Pickering emulsion interfacial delivery system (EIDS).