The Association between GLP-1 Receptor-Based Agonists and the Incidence of Asthma in Patients with Type 2 Diabetes and/or Obesity: A Meta-Analysis.

Objective: Recent studies have indicated potential anti-inflammatory effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on asthma, which is often comorbid with type 2 diabetes mellitus (T2DM) and obesity. Therefore, we conducted a meta-analysis to assess the association between the administration of glucagon-like peptide-1 (GLP-1) receptor-based agonists and the incidence of asthma in patients with T2DM and/or obesity.

Methods: PubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials, and were systematically searched from inception to July 2023.

[Aspartic Acid Generated in the Process of Chlorination Disinfection By-product Dichloroacetonitrile].

In this study, a method was developed for the determination of dichloroacetonitrile (DCAN) in drinking water by liquid- liquid micro-extraction and gas chromatography/mass spectrometry ( LLE-GC/MS), which used 1,2-dibromopropane as the internal standard and methyl tertiary butyl ether (MTBE) as the extractant for high accuracy. The aspartic acid was used as the precursor of the DCAN formation during chlorination and the influencing factors were evaluated. The formation mechanism of DCAN was also discussed.

SPECT and near-infrared fluorescence imaging of breast cancer with a neuropilin-1-targeting peptide.

Breast cancer is the most common malignant cancer and is the leading cause of cancer death among females. Molecular imaging is a promising approach for the early detection and staging of breast cancer as well as for assessing therapeutic responses. Tumor-targeting peptides are effective targeting vehicles for molecular imaging.

The prognostic value of platelet endothelial cell adhesion molecule-1 in non-small-cell lung cancer patients.

Our previous studies have shown that platelet endothelial cell adhesion molecule-1 (PECAM-1), a member of the immunoglobulin superfamily, is a critical mediator of anchorage-independent growth and anoikis resistance in lung carcinoma cells. The purpose of this study was to analyze the protein expression of PECAM-1 in non-small-cell lung carcinoma (NSCLC) tissues and its clinical significance in NSCLC patients. By immunohistochemical analysis, high microvessel density (MVD) of PECAM-1 was detected in the stromal tissues of NSCLC.