Publications by authors named "Meng Qi Huo"
Introduction: Drug discovery research targeting SARS-CoV-2 and other emerging pathogens remains critically important. Active compounds derived from plants frequently serve as lead compounds for further drug discovery; however, numerous unrelated chemical constituents in crude extracts may obscure the effective ingredients in LC-MS analysis.
Objective: The aim of this study is to construct a biolayer interferometry (BLI)-based system for recognizing active ingredients that inhibit the main protease (Mpro) of SARS-CoV-2 and to identify the active chemical components binding to Mpro from herbal medicines.
Article Synopsis
- Lonicerae Japonicae Flos is traditionally used for its heat-clearing and detoxifying properties, with a stable recognition of its effectiveness in Chinese medicine.
- The study aims to identify the active ingredients and their roles in these effects, utilizing a systematic approach to establish a model that links pharmacology to the observed benefits.
- Key findings suggest that chlorogenic acid and linalool may serve as potential efficacy markers in the IL-1 and IL-6 signaling pathways, indicating their significance in the heat-clearing and detoxifying actions of Lonicerae Japonicae Flos.
Article Synopsis
- This paper investigates the efficacy systems of two key components of traditional Chinese medicine: tanshinones and salvianolic acids, utilizing literature mining and biological network construction.
- The study explores the molecular-level relationships and functions of these components, identifying 201 targets and 12 pathway networks for salvianolic acids, and 189 targets and 11 pathway networks for tanshinones.
- It concludes that while the pharmacological functions differ between the two compounds, they share common overall benefits in promoting blood circulation and calming the nervous system.
The quality marker(Q-marker) of traditional Chinese medicine(TCM) is a new concept of TCM quality control proposed in recent years. It is a hot issue in the research of modern Chinese medicine. The TCM efficacy is a high-level summary of the TCM therapeutic effect under the guidance of TCM theory.
View Article and Find Full Text PDFAstragalus membranaceus (HUANG QI, HQ) is a kind of traditional Chinese medicine. Researchers have widely concerned its antitumor effect. At present, there is still a lack of research on the treatment of laryngeal cancer with HQ.
View Article and Find Full Text PDFThe efficacy of traditional Chinese medicine is the therapeutic effect of the drug on the body. The nature of traditional Chinese medicine is a further generalization of the effect of efficacy,and there is an intrinsic relationship between efficacy and nature of traditional Chinese medicine. In this study,the nature-effect relationship is found on the whole level,through the research mode of " nature combination-targets of traditional Chinese medicine-modules of protein interaction network-efficiency".
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