Dysregulation of Calcium Homeostasis: An Important Factor Leading to Ferroptosis in Cardiovascular Diseases.

Cardiovascular disease is a circulatory system disease involving the heart and blood vessels, which is one of the main causes of human health loss and even life-threatening. Ca is an important signal molecule. Free calcium ions in the cytoplasm are involved in various physiological and biochemical reactions of cells.

Abdominal obesity and frailty progression in population across different Cardiovascular-Kidney-Metabolic syndrome stages: a nationwide longitudinal study.

Background: Abdominal obesity, assessed via the body roundness index (BRI), is a critical determinant of health outcomes. This study explores the association between abdominal obesity and frailty progression across different stages of Cardiovascular-Kidney-Metabolic (CKM) syndrome in a nationwide longitudinal cohort.

Methods: Data were derived from the China Health and Retirement Longitudinal Study, including individuals aged ≥ 45 years.

Identification of Subtypes and Diagnostic Markers Related to Necroptosis in Sepsis.

Sepsis is a serious systemic infection with a high mortality rate. More and more evidence suggested that necroptosis plays a crucial role in the pathogenesis and progression of sepsis. This study aimed to elucidate the biological function and clinical significance of necroptosis in sepsis, and identify new potential biomarkers to improve the diagnosis and treatment of sepsis.

Predictive Value of Noninvasive Cardiac Function Monitoring Combined With GRACE Score for Short-Term Outcomes in Patients With ST-Segment Elevation Myocardial Infarction.

Objective: To investigate the correlation between non-invasive cardiac function monitoring indexes and recent adverse prognosis in patients with STEMI. The hemodynamic indexes with high diagnostic value were selected to construct a new risk prediction model combined with GRACE scores, and the efficiency of the new prediction model was evaluated.

Methods: STEMI patients who met the inclusion and exclusion criteria were selected.

Multimodal Artificial Intelligence-Based Virtual Biopsy for Diagnosing Abdominal Lavage Cytology-Positive Gastric Cancer.

Gastric cancer with peritoneal dissemination remains a significant clinical challenge due to its poor prognosis and difficulty in early detection. This study introduces a multimodal artificial intelligence-based risk stratification assessment (RSA) model, integrating radiomic and clinical data to predict peritoneal lavage cytology-positive (GC-CY1) in gastric cancer patients. The RSA model is trained and validated across retrospective, external, and prospective cohorts.

The effects of an unfamiliar experimenter on proactive and reactive control in children.

Cognitive control development across childhood is critical for later academic achievement. Despite recent advances in the comprehension of how the context influences cognitive control development, no study has ever addressed whether one of the most frequent contextual features of children's lives (i.e.

Protocol of the Nurses' Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study.

Introduction: Due to high workload, shift work and shortage of human resources, nurses are vulnerable to various mental health problems which are significantly related to their physical health, patient safety and healthcare quality. The long-term monitoring of nurses' mental health and identifying its risk factors are necessary. Accounting for more than one-fifth of global nurses, Chinese nurses have a demanding healthcare workload, especially in tertiary hospitals, yet there is no national cohort concerning their mental health and associated factors.

Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients.

Background: Hemoglobin, albumin, lymphocyte and platelet (HALP) score is derived from the counts of hemoglobin, albumin, lymphocytes, and platelets. It serves as a valuable tool for assessing both inflammation and nutritional status in critically ill patients. However, there hasn't been a specific study exploring the role of the HALP score in critically ill patients.

Preoperative liquid biopsy transcriptomic panel for risk assessment of lymph node metastasis in T1 gastric cancer.

Background: The increasing incidence of early-stage T1 gastric cancer (GC) underscores the need for accurate preoperative risk stratification of lymph node metastasis (LNM). Current pathological assessments often misclassify patients, leading to unnecessary radical surgeries.

Methods: Through analysis of transcriptomic data from public databases and T1 GC tissues, we identified a 4-mRNA panel (SDS, TESMIN, NEB, and GRB14).

Renal impairment and in-hospital adverse renal events in critically ill patients assessed by age-adapted estimated glomerular filtration rate criteria.

Background: Impaired renal function (IRF) is associated with an elevated risk of major adverse renal events (MARE). However, the relationship between age-adapted estimated glomerular filtration rate (eGFR) criteria and in-hospital MARE has not been extensively studied in critically ill patients. Furthermore, the impact of eGFR trajectory changes on in-hospital MARE in this patient population remains underexplored.

Effects of laminarin and ferulic acid on pasting, rheology, freeze-thaw stability and in vitro digestion of cassava starch.

This study aimed to investigate the effects of laminarin (LA) and ferulic acid (FA) on the gelatinization, rheological properties, freeze-thaw stability, and digestibility of cassava starch (CS). The results indicated that LA increased the peak viscosity, trough viscosity, final viscosity, storage modulus, and loss modulus of CS, while decreasing the breakdown viscosity. Conversely, FA exerted opposite effects.

Network of job demands-resources and depressive symptoms in critical care nurses: a nationwide cross-sectional study.

Background: Critical care nurses are vulnerable to depression, which not only lead to poor well-being and increased turnover intention, but also affect their working performances and organizational productivity as well. Work related factors are important drivers of depressive symptoms. However, the non-liner and multi-directional relationships between job demands-resources and depressive symptoms in critical care nurses has not been adequately analyzed.

Association between stress hyperglycemia ratio and all-cause mortality in critically ill patients with sepsis: results from the MIMIC-IV database.

Background: This study aimed to explore the association between the stress hyperglycemia ratio (SHR) and short- and long-term outcomes in critically ill patients with sepsis.

Methods: This retrospective observational cohort study was conducted using the Medical Information Mart for Intensive Care-IV (MIMIC-IV v2.2) database.

Design and synthesis of N-(3-cyanothiophen-2-yl)-2-phenoxyacetamide-based α-glucosidase inhibitors.

This study investigates the design and synthesis of a series of novel selective α-glucosidase inhibitors based on N-(3-cyanothiophen-2-yl)-2-phenoxyacetamide framework, employing a bioisosterism strategy. Among the nineteen newly synthesized analogs, compound 4d9 demonstrated the highest α-glucosidase inhibitory potency (IC = 2.11 μM) when compared to the established inhibitors Acarbose (IC = 327.

Machine learning-based dynamic predictive models for prognosis and treatment decisions in patients with liver metastases from gastric cancer.

Gastric cancer with liver metastasis (GCLM) often has a poor prognosis. Therefore, it is crucial to identify risk factors affecting their overall survival (OS) and cancer-specific survival (CSS). This study aimed to construct practical machine learning models to predict survival time and help clinicians choose appropriate treatments.

Transcriptomics-Based Liquid Biopsy for Early Detection of Recurrence in Locally Advanced Gastric Cancer.

The study presents a transcriptomics-based liquid biopsy approach for early recurrence detection in locally advanced gastric cancer (LAGC). Four mRNA biomarkers (AGTR1, DNER, EPHA7, and SUSD5) linked to recurrence are identified through transcriptomic data analysis. A Risk Stratification Assessment (RSA) model combining these biomarkers with clinical features showed superior predictive accuracy for postoperative recurrence, with AUCs of 0.

Head nurse ethical competence and transformational leadership: a cross-sectional study.

Background: Ethical competency is important to head nurses' transformational leadership, however, few researches have explored their correlation, Additionally, most studies used variable-oriented approach to examine ethical competence, without considering it as a multidimensional concept. This study aimed to identify the latent profiles of head nurses' ethical competence and examine differences in transformational leadership across latent profiles.

Methods: Convenience sampling was used to recruit 329 head nurses from four tertiary hospitals in Changsha, Hunan province, China.

Design and Synthesis of 1,4-Diformyl-Piperazine Ferrostatin-1 Derivatives as Novel Ferroptosis Inhibitors.

The present study focuses on the design and synthesis of novel 1,4-diformyl-piperazine-based ferrostatin-1 (Fer-1) derivatives, and their evaluation against ferroptosis activity. The synthesized compounds demonstrated significant anti-ferroptosis activity in human umbilical vascular endothelial cells (HUVECs), with Compound 24 showing the highest potency. Mechanistic studies revealed that Compound 24 effectively reduced intracellular reactive oxygen species (ROS) levels, mitigated mitochondrial damage, and enhanced glutathione peroxidase 4 (GPX4) expression.

Design, Synthesis, and Biological Evaluation of New Improved Ferrostatin-1 Derived Ferroptosis Inhibitors.

Ferrostatin-1 (Fer-1), a first potent ferroptosis inhibitor, faces limitations in clinical use due to its low potency and metabolic instability. This study introduces a series of novel Ferrostatin-1 analogs designed to enhance plasm stability. Our design strategy focused on the modification of the 3-NH of Fer-1 with benzenesulfonyl groups, resulting in analogs 9-25.

Synthesis and biological evaluation of ferrostatin-based diamide derivatives as new ferroptosis inhibitors.

Ferroptosis, a distinct type of cell death caused by iron and lipid peroxidation, has been associated with several diseases, including cardiovascular disorders. Ferrostatin-1 (Fer-1) is a known ferroptosis inhibitor, but its clinical application is limited by low efficacy and stability. In the present study, a series of Fer-1-based diamide derivatives was synthesized and evaluated to enhance ferroptosis inhibition and in vitro metabolic stability.

Extragastrointestinal stromal tumors with diffuse membranous distribution with bleeding: A case report.

Background: Extragastrointestinal stromal tumors (EGIST) and gastrointestinal stromal tumors are of similar pathological type and form. Here we report a rare case of EGIST diffusely distributed in membranous tissue in abdominal cavity, the feature of which included diffuse tumors at membranous tissue in entire abdominal cavity and spontaneous bleeding of the tumors.

Case Summary: The patient was a 71-year man and hospitalized due to continuous pain at lower abdomen for more than 10 days.

Correlation between blood pressure and mortality in older critically ill patients: Insights from a large intensive care unit database.

Objectives: The study aimed to investigate the relationship between blood pressure (BP) levels and mortality among critically ill older adults in the intensive care unit (ICU), establish optimal BP target for this population, and assess the mediating effect of severe malnutrition on BP-related mortality.

Methods: Data were extracted from the Medical Information Mart for Intensive Care IV version 2.2 database, focusing on critically ill patients aged 80 years and older.