Transformation Pathway from CdSe Nanoplatelets with Absorption Doublets at 373/393 nm to Nanoplatelets at 434/460 nm.

For those colloidal semiconductor CdSe nanospecies that exhibit sharp optical absorption doublets, different explanations have appeared in the literature regarding their morphological nature and formation, with no consensus reached. Here, we discuss the transformation pathway in two types of CdSe nanoplatelets (NPLs), from NPL-393 to NPL-460, exhibiting absorption doublets at 373/393 and 433/460 nm, respectively. Synchrotron-based small/wide-angle X-ray scattering (SAXS/WAXS) was performed to monitor the transformation associated with the temperature.

Comparative study on treatment of acute cerebral infarction between mechanical thrombectomy by micro catheter and thrombectomy by Solitaire AB stent.

Background: Acute cerebral artery occlusion is a common disease with high morbidity and mortality. At present, the commonly used mechanical thrombectomy schemes are mechanical thrombectomy and stent thrombectomy. However, the clinical differences between the two methods is not fully understood.

A Trilayered Composite Fabric with Directional Water Transport and Resistance to Blood Penetration for Medical Protective Clothing.

Functional textiles with enhanced moisture management can facilitate sweat transport away from the skin to improve personal comfort. However, porous materials exhibit low capability of preventing the intrusion of external liquids, becoming a bottleneck in the design of medical protective clothing. Herein, a trilayered composite fabric based on a gradient wettability structure is demonstrated for directional water transport and resistance to blood penetration.

Total-body parametric imaging using the Patlak model: Feasibility of reduced scan time.

Purpose: This study explored the feasibility of reducing the scan time of Patlak parametric imaging on the uEXPLORER.

Methods: A total of 65 patients (27 females and 38 males, age 56.1 ± 10.

In vivo self-assembled drug nanocrystals for metastatic breast cancer all-stage targeted therapy.

Chemotherapy is still the mainstay treatment for metastatic triple-negative breast cancers (TNBC) currently in clinical practice. The unmet needs of chemotherapy for metastatic TNBC are mainly from the insufficient drug delivery and unavailable targeting strategy that thwart the whole progression of metastatic TNBC. The in vivo ligands-mediated active targeting efficiency is usually affected by protein corona.

Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs.

Angiogenesis inhibitors targeting the VEGF signaling pathway are developed into drugs for the treatment of vaious diseases, such as cancer, rheumatoid arthritis, and age-related macular degeneration. Recent studies have revealed that oleanolic acid (OA), a natural pentacyclic triterpenoid, inhibited the VEGF/VEGFR2 signaling pathway and angiogenesis in HUVECs, which may represent an attractive VEGF inhibitor. In this paper, rational structural modification towards OA was performed in order to improve its inhibitory effects aganist VEGF and anti-angiogenesis potential.

Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.

Oxidized low-density lipoprotein (oxLDL)-induced endothelium injury promotes the development of atherosclerosis. It has been reported that homoplantaginin, a flavonoid glycoside from the traditional Chinese medicine R. Br.

Parametric image generation with the uEXPLORER total-body PET/CT system through deep learning.

Purpose: Total-body dynamic positron emission tomography/computed tomography (PET/CT) provides much sensitivity for clinical imaging and research, bringing new opportunities and challenges regarding the generation of total-body parametric images. This study investigated parametric [Formula: see text] images directly generated from static PET images without an image-derived input function on a 2-m total-body PET/CT scanner (uEXPLORER) using a deep learning model to significantly reduce the dynamic scanning time and improve patient comfort.

Methods: [Formula: see text]F-Fluorodeoxyglucose ([Formula: see text]F-FDG) 2-m total-body PET/CT image pairs were acquired for 200 patients (scanned once) with two protocols: one parametric PET image (60 min, 0[Formula: see text]60 min) and one static PET image (10 min, range of 50[Formula: see text]60 min).

Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation.

Objective: To discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation.

Methods: Specimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluorescence hybridization, and follow-up.

Results: In accordance with the morphological and histological structural features of the cancer cells as well as the area ratio of the mucus, gastric adenocarcinoma with mucinous differentiation was divided into four types, namely pure mucinous carcinoma, intraductal papillary mucinous carcinoma, signet ring cell type mucinous carcinoma, and mixed cell type mucinous carcinoma.

Significantly correlation between tourism and COVID-19: evidence from 178 countries and territories.

Introduction: The high development of tourism is considered a factor that facilitates the global spread of infectious diseases. The association between tourism and the epidemic of coronavirus diseases 2019 (COVID-19) remains unclear.

Methodology: We retrieved the data of COVID-19 in 178 countries/territories from the Center for Systems Science and Engineering at Johns Hopkins University.

Polyacrylic acid--polystyrene-passivated CsPbBr perovskite quantum dots with high photoluminescence quantum yield for light-emitting diodes.

We report a novel strategy for the preparation of CsPbBr perovskite quantum dots by polyacrylic acid--polystyrene ligands, which exhibited high stability and photoluminescence quantum yields. The fabricated white light-emitting diodes exhibited luminescence performance with the colour rendering index of 65.5, and a correlated colour temperature of 5464 K.

A multifunctional carbon dot-based nanoplatform for bioimaging and quaternary ammonium salt/photothermal synergistic antibacterial therapy.

The emergence of drug resistance and superbugs poses a devastating threat to public health and can even lead to death. Thus, it is significant to develop a novel antibacterial agent to combat bacterial infections. Herein, we developed quaternary ammonium salt (QAS) modified near-infrared carbon dots (RCDs-C), which possesses synergistic antibacterial performance under 808 nm irradiation.

Evaluation of Amide Proton Transfer-Weighted Imaging for Lung Cancer Subtype and Epidermal Growth Factor Receptor: A Comparative Study With Diffusion and Metabolic Parameters.

Background: Lung cancer is one of the most devastating diseases worldwide, and it is meaningful to assess the subtype and epidermal growth factor receptor (EGFR) status in lung cancer noninvasively by imaging methods.

Purpose: To differentiate noninvasively small cell lung cancer (SCLC) from nonsmall cell lung cancer (NSCLC), and EGFR mutation-type from wild-type NSCLC by comparing amide proton transfer-weighted imaging (APTWI), diffusion-weighted imaging (DWI), and 2-[ F]-fluoro-2-deoxy-d-glucose positron emission tomography ( F-FDG PET).

Study Type: Prospective.

Global, Regional, and National Estimates of Nutritional Deficiency Burden among Reproductive Women from 2010 to 2019.

Women of reproductive age (15-49 years) are often considered a vulnerable population affected by nutritional deficiencies, impairing their health and that of their offspring. We briefly introduced (a) the incidence and disability-adjusted life years (DALYs) trends from 2010 to 2019 and (b) the correlation between sex differences and income levels and nutritional deficiencies of reproductive women firstly. Notably, the burden of overall nutritional deficiencies among reproductive women remained generally stable from 2010 to 2019, whereas the iodine and vitamin A deficiencies as a subcategory were associated with increased incidence rates and DALYs, respectively.

TRPV4 and PIEZO Channels Mediate the Mechanosensing of Chondrocytes to the Biomechanical Microenvironment.

Articular cartilage and their chondrocytes are physiologically submitted to diverse types of mechanical cues. Chondrocytes produce and maintain the cartilage by sensing and responding to changing mechanical loads. TRPV4 and PIEZOs, activated by mechanical cues, are important mechanosensing molecules of chondrocytes and have pivotal roles in articular cartilage during health and disease.

Macroscale Conjugated Microporous Polymers: Controlling Versatile Functionalities Over Several Dimensions.

Since discovered in 2007, conjugated microporous polymers (CMPs) have been developed for numerous applications including gas adsorption, sensing, organic and photoredox catalysis, energy storage, etc. While featuring abundant micropores, the structural rigidity derived from CMPs' stable π-conjugated skeleton leads to insolubility and thus poor processability, which severely limits their applicability, e.g.

Identification of histological features of endometrioid adenocarcinoma based on amide proton transfer-weighted imaging and multimodel diffusion-weighted imaging.

Background: Noninvasive identification of the histological features of endometrioid adenocarcinoma is necessary. This study aimed to investigate whether amide proton transfer-weighted imaging (APTWI) and multimodel (monoexponential, biexponential, and stretched exponential) diffusion-weighted imaging (DWI) could predict the histological grade of endometrial adenocarcinoma (EA). In addition, we analyzed the correlation between each parameter and the Ki-67 index.

Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.

Inhibition of oxidized low-density lipoprotein (oxLDL)-induced vascular endothelial cell (VEC) injury is one of the effective strategies for treating atherosclerosis. In the present study, a series of novel marine phidianidine-inspired indole-1,2,4-oxadiazoles was designed, synthesized, and evaluated for their effects against oxLDL-induced injury in VECs. Among them, compound D-6, displaying the most effective protective activity, was found to inhibit oxLDL-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs.

An artificial intelligence powered platform for auto-analyses of spine alignment irrespective of image quality with prospective validation.

Background: Assessment of spine alignment is crucial in the management of scoliosis, but current auto-analysis of spine alignment suffers from low accuracy. We aim to develop and validate a hybrid model named SpineHRNet+, which integrates artificial intelligence (AI) and rule-based methods to improve auto-alignment reliability and interpretability.

Methods: From December 2019 to November 2020, 1,542 consecutive patients with scoliosis attending two local scoliosis clinics (The Duchess of Kent Children's Hospital at Sandy Bay in Hong Kong; Queen Mary Hospital in Pok Fu Lam on Hong Kong Island) were recruited.

Scalable Fabrication of Conjugated Microporous Polymer Sponges for Efficient Solar Steam Generation.

Seawater evaporation realized by solar-thermal conversion represents one of the most sustainable and effective strategies to obtain fresh water. Many approaches have been proposed to achieve high efficiencies of solar-thermal conversion, but their practical applications are limited by the low scalability. Herein, novel porphyrin/aniline-based conjugated microporous polymers (PACMPs) are synthesized a Buchwald-Hartwig coupling reaction, which are then integrated with polyurethane sponges a simple dip-coating technique.

Characterization of the key odorants and their content variation in Niulanshan Baijiu with different storage years using flavor sensory omics analysis.

Niulanshan Baijiu (NLS) is a light-flavor Baijiu (LFB) with a long history. The aroma-active compounds in six NLSs with different storage years were analyzed using gas chromatography-olfactometry-mass spectrometry (GC-O-MS), coupled with Osme and aroma extraction dilution analysis (AEDA). A total of 59 odorants were identified, 5 odorants of them were, for the first time, identified as aroma-active compounds of LFB.

Novel Wireless Bioimpedance Device for Segmental Lymphedema Analysis Post Dual-Site Free Vascularized Lymph Node Transfer: A Prospective Cohort Study.

An innovative wireless device for bioimpedance analysis was developed for post-dual-site free vascularized lymph node transfer (VLNT) evaluation. Seven patients received dual-site free VLNT for unilateral upper or lower limb lymphedema. A total of 10 healthy college students were enrolled in the healthy control group.