The role of serum and urine interleukin-8 on acute pyelonephritis and subsequent renal scarring in children.

Background: Interleukin (IL)-8 acts as a potent neutrophils chemoattractant responsible for the migration of neutrophils into the infected renal tissue to protect against invading pathogens. The aim of this study was to assess the role of IL-8 on acute-phase pyelonephritis and later renal scarring in children.

Patients And Methods: A total of 124 children with a first-time febrile urinary tract infection (UTI) were studied.