Publications by authors named "Meng Lin Chen"

Background: Endometriosis mainly occurs in female pelvic organs. Endometriosis in the kidney is extremely rare.

Case Presentation: We herein describe a case of a 19-year-old girl with occasional mild abdominal pain associated with an ectopic left kidney.

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Article Synopsis
  • - The study analyzed complete genome sequences of SARS-CoV-2 collected from 177 COVID-19 patients at a hospital in Guangzhou, focusing on the diversity and mutation characteristics of the virus between October 2020 and May 2021.
  • - Key findings indicated a peak in imported COVID-19 cases from the U.S. in May 2021, with significant variants like B.1.1.7 and B.1.351 identified alongside unique mutations not previously documented in major databases.
  • - The research highlighted that the ORF1a protein had the highest mutation density, and the D614G mutation in the spike protein was most common, suggesting the emergence of diverse lineages and the potential for further viral evolution
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CYP2B10 is responsible for metabolism and detoxification of many clinical drugs. Here, we aimed to investigate a potential role of Period 2 (PER2) in regulating expression of hepatic CYP2B10. Regulatory effects of PER2 on hepatic expression of CYP2B10 and other enzymes were determined using deficient mice with exons 4-6 deleted (named mice).

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Ethnopharmacological Relevance: Walnut kernel, a well-known TCM, is often used after being defatted in tradition. And defatted walnut powder extract (DWPE) has the actions of tonifying the liver and kidney, dissipating stagnation and removing blood stasis, which has the effect on non-alcoholic fatty liver disease (NAFLD). However, the effective components of DWPE in vivo were unclear and the multiple mechanisms of DWPE against NAFLD have not been explored.

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Ethnopharmacological Relevance: Walnut kernel has the actions of removing meteorism, dissipating stagnation and removing blood stasis and is used after being defatted in TCM. Defatted walnut powder extract (DWPE) has the abilities of anti-oxidation and lowering lipid levels in vivo. However, the effects and the potential mechanisms of DWPE on NAFLD have not been explored.

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Kidney transplantation is the treatment of choice for patients with end-stage renal disease, as it extends survival and increases quality of life in these patients. However, chronic allograft injury continues to be a major problem, and leads to eventual graft loss. Early detection of allograft injury is essential for guiding appropriate intervention to delay or prevent irreversible damage.

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A positive captopril renography indicates that patient's hypertension is renin dependent, most commonly caused by renal artery stenosis. The authors reported a case of positive captopril renography; however, CT demonstrated that renal arteries were intact, but there was a huge chromophobe renal cell carcinoma. Renin-dependent hypertension was relieved soon after nephrectomy.

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Objective: To explore the value of diffusion-weighted imaging (DWI), H-magnetic resonance spectroscopy (1H-MRS) and 3D whole-brain arterial spin labeling (3D ASL) in the diagnosis of medulloblastoma in the posterior cranial fossa.

Methods: The magnetic resonance imaging (MRI) findings of 16 patients with pathologically confirmed medulloblastoma in the posterior cranial fossa were analyzed retrospectively. All the patients were examined with plane and enhanced brain MRI scans; 5 patients also underwent examinations with DWI, 12 with MRS, and 5 with 3D ASL.

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An efficient access to optically active sulfahydantoins, 4-aryl-1,2,5-thiadiazolidin-3-one 1,1-dioxides, was developed through palladium-catalyzed asymmetric hydrogenation of the corresponding cyclic N-sulfonylketimines with up to 98% ee.

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A 54-year-old man, a case of prostate cancer, underwent radical prostatectomy and hormone therapy. Elevated prostate-specific antigen level developed 7 years later, but pelvic MRI and bone scan revealed negative results. Radiotherapy was performed under the suspicion of local recurrence but in vain.

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