A high-efficiency oil/water emulsion separation sponge based on sodium alginate-loofah composite gels.

Nowadays, many reported oil/water (O/W) emulsion filter materials have issues such as susceptibility to fouling, complex processing, high costs, and environmental unfriendliness. Herein, a novel O/W emulsion separation membrane-like sponge (SA/GO-SL) is prepared in this study by utilizing reshaped waste loofah (LF) as skeleton, the in situ formed sodium alginate (SA) gels as binder, and the graphene oxide (GO) added into the gels as functional component. Reshaped LF provides an enough anti-pressure ability and micron-sized pores structure, which guarantees a water flux of 63.

HOXA10-AS Enhances Gastric Cancer Cell Proliferation, Migration, and Invasion via the p38 MAPK/STAT3 Signaling Pathway.

Gastric cancer (GC) represents a major global health concern, with over 1 million new cases diagnosed annually worldwide. Emerging studies have highlighted the significant correlation between long noncoding RNAs (lncRNAs) and the progression of GC. The objective of the current study is to investigate the roles and mechanism of lncRNA homeobox A10 antisense RNA (HOXA10-AS) in modulating malignant properties of GC cells.

Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Systemic Lupus Erythematosus via Glucose Metabolism of CD4T Cells.

Background: T cells play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE), with their functions regulated by various metabolic pathways. This study explores SLE pathogenesis and the therapeutic effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) via metabolic reprogramming.

Methods: Clinical data and peripheral blood samples were collected from 15 SLE patients and matched healthy controls.

Hypoxic compound exercise improves cardiac function in Drosophila high fructose diet via KHK.

Overconsumption of fructose has been linked to the development of systemic metabolic and cardiac diseases, yet few studies have focused on the link between cardiac fructose metabolism and the development of heart disease. Low-oxygen complex exercise is considered an effective means of treating and preventing metabolic diseases and improving cardiac function, however, it is unclear, the link between low-oxygen complex exercise and high-fructose-induced heart disease. Therefore, the aim of this study was to investigate the effect of hypoxic complex exercise on heart disease on a high fructose diet.

Broccoli ( L. var. Planch) alleviates metabolic-associated fatty liver disease through regulating gut flora and lipid metabolism the FXR/LXR signaling pathway.

The increased consumption of dietary fats contributes to the development of MAFLD (metabolic fatty liver disease). The ability of broccoli to enhance lipid metabolism has attracted researchers' attention. Researchers fed C57BL/6 mice a 12-week HFD to ensure the induction of MAFLD.

Latarjet procedure versus iliac crest autograft transfer for anterior shoulder instability: a systematic review and meta-analysis of comparative studies.

Background: Anterior shoulder instability with glenoid bone loss presents a challenge in orthopedic surgery. The Latarjet and iliac crest bone graft transfer (ICBGT) procedures are commonly employed for its management, but direct comparative evidence is insufficient.

Methods: Following PRISMA guidelines, a comprehensive search of PubMed, EMBASE, Cochrane Library, and Web of Science was conducted.

Adverse childhood experiences, sleep quality/duration and later-life lower extremity function among older adults in China: evidence from CHARLS.

Objective: This study aimed to explore the relationship between adverse childhood experiences (ACEs), sleep, and lower extremity function in older adults using a nationally representative cohort.

Methods: This study included 4,439 participants aged 60 years or older (mean age: 67.2 ± 5.

Magnetic Resonance Imaging Study on Older Patients with Cognitive Impairment and Depression.

Background: Understanding brain changes in older patients with depression and their relationship with cognitive abilities may aid in the diagnosis of depression in this population. This study aimed to explore the association between brain lesions and cognitive performance in older patients with depression.

Methods: We utilized magnetic resonance imaging data from a previous study, which included older adults with and without depression.

Euchrestifolines A-O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from Murraya euchrestifolia.

Fifteen novel carbazole alkaloids, euchrestifolines A-O (1-15), were obtained from Murraya euchrestifolia. Their structures were elucidated by spectroscopic analysis, Mosher's ester, calculated ECD, and transition metal complex ECD methods. Notably, euchrestifolines A-C (1-3) are the first naturally occurring pyrrolidone carbazoles to be identified, while euchrestifolines D-F (4-6) represent rare carbazole alkaloids containing a phenylpropanyl moiety; euchrestifoline G (7) features a unique benzopyranocarbazole skeleton.

Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation.

NADPH oxidase 1 (Nox1) is a major isoform of Nox in vascular smooth muscle cells (VSMCs). VSMC activation and extracellular matrix (ECM) remodelling induce abdominal aortic aneurysm (AAA). In this study, we aim to determine the role of Nox1 in the progression of AAA and explore the underling mechanism.

One-dimensional multilevel stalactite-like NiS-Fe(MoS) bifunctional electrocatalyst with excellent oxygen evolution reaction and overall water splitting performance.

Sluggish multi-electron transfer process of the oxygen evolution reaction (OER) hinders the further advancement of electrolysis for hydrogen production. Here, a one-dimensional multilevel stalactite-like NiS-Fe(MoS) with excellent oxygen evolution performance was successfully synthesized using a universal two-step hydrothermal method. The nanorod arrays increase the active area and promote electron transfer.

Axis screw parallel to the sagittal plane versus traditional pedicle screw in the treatment of atlantoaxial fixation: a finite element study.

Background: This study aims to conduct a finite element analysis (FEA) to assess the bio-mechanical properties of C2 sagittal-parallel pedicle screw (PPS) in fixation for atlantoaxial instability, thereby providing a theoretical foundation for its clinical application.

Methods: A total of 5 intact C1-2 finite element models were established. Based on this, instability models were developed and two different fixation methods were applied for each model: C1 lateral mass screw (LMS) combined with C2 sagittal-parallel pedicle screw (C1LMS + C2PPS), and C1 lateral mass screw combined with C2 traditional pedicle screw (C1LMS + C2PS).

The potential of kaempferol in digestive system tumors: recent advances and mechanistic insights.

Digestive system neoplasms are a heterogeneous group of cancers characterized by diverse symptoms, complex diagnosis, and treatment. Prognosis is poor and influenced by multiple factors, making early detection and comprehensive treatment crucial for patient survival. Kaempferol, a flavonoid compound, has attracted attention due to its anti-tumor biological activity, holding promise as a potential drug for treating digestive system neoplasms.

NO inhibitory constituents from Glycosmis craibii var. glabra.

Six novel compounds, comprising three quinolones (1a, 1b, and 2) and three flavanones (3-5), along with seven known analogs (6-13), were isolated from the 95% EtOH extract of the stems and leaves of Glycosmis craibii var. glabra. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis.

Simultaneous metabolomics and lipidomics analysis based on 4in1 online analysis system reveal metabolic signatures in atherosclerotic mice.

Developing efficient and comprehensive analysis methods for metabolomics and lipidomics in the biological tissues and body fluids is essential for understanding the disease mechanisms. Although various two-dimensional liquid chromatography-mass spectrometry (2D-LC-MS) methods have been proposed to expand metabolite coverage, achieving higher efficiency in integrated metabolomics and lipidomics studies remains a technical challenge. In this work, a novel 4in1 online analysis system with excellent reproducibility and mass accuracy was constructed for metabolomics and lipidomics study in various biological samples from atherosclerotic mice.

Splicing Hollow-Core Fiber with Standard Glass-Core Fiber with Ultralow Back-Reflection and Low Coupling Loss.

A main, yet-unsolved challenge in splicing hollow-core fiber (HCF) into standard single-mode fiber (SMF) systems lies in managing the strong Fresnel back-reflection that occurs when the light travels from the empty core of the HCF into the glass core of the SMF or vice versa. This impacts the performance of fiber systems that combine SMFs and HCFs due to effects such as multipath interference. Here, we demonstrate a new technique that combines angle-cleaving the HCF, which reduces the back-reflection, with offset-splicing the mode-field adapter to the SMF, which compensates for the refraction at the glass-air interface, enabling us to achieve low coupling loss.

Stimuli-Responsive NO Delivery Platforms for Bacterial Infection Treatment.

The prevalence of drug-resistant bacterial infections has emerged as a grave threat to clinical treatment and global human health, presenting one of the foremost challenges in medical care. Thus, there is an urgent imperative to develop safe and efficacious novel antimicrobial strategies. Nitric oxide (NO) is a recognized endogenous signaling molecule, which plays a pivotal role in numerous pathological processes.

Extracellular Vesicle-Inspired Minimalist Flexible Nanocapsules Assembled with Whole Active Ingredients for Highly Efficient Enhancement of DC-Mediated Tumor Immunotherapy.

The development of nanovaccines capable of eliciting tumor-specific immune responses holds significant promise for tumor immunotherapy. However, many nanovaccine designs rely heavily on incorporating multiple adjuvants and carriers, increasing the biological hazards associated with these additional components. Here, this work introduces novel flexible nanocapsules (OVAnano) designed to mimic extracellular vesicles, primarily using the ovalbumin antigen and minimal polyethylenimine adjuvant components.

Status quo and factors of depression and anxiety in patients with non-muscle invasive bladder cancer after plasma electrocision.

Background: Bladder cancer is a type of cancer with a high incidence in men. Plasma electrosurgery (PES) is often used in the treatment of bladder cancer. Postoperative complications often cause depression and anxiety in patients after surgery.