Engineered Microalgae for Photo-Sonodynamic Synergistic Therapy in Breast Cancer Treatment.

Dynamic therapies such as photodynamic therapy (PDT) and sonodynamic therapy (SDT) have potential in cancer treatment. Microalgae have attracted increasing attention because of their high active mobility, flexibility in terms of functionality, and good biocompatibility. In this study, surface-engineered microalgae Chlorella vulgaris (Chl) modified with metal‒organic framework (MOF) nanoparticles (denoted Chl-MOF) are successfully developed for synergistic photo-sonodynamic therapy and immunotherapy.

Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia.

Targeting XPO1 inhibition has emerged as a promising therapeutic strategy in cancer treatment. Despite the numerous XPO1 inhibitors reported to date, no XPO1 degraders have been disclosed. In this study, we reported the design, synthesis and biological characterization of small-molecule XPO1 degraders based upon the proteolysis targeting chimera (PROTAC), marking the first public disclosure of XPO1 degraders.

Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase.

Butyrate has been proposed as a drug therapy by acting as a lysine deacetylase (KDAC) inhibitor and elevating protein acetylation, in particular on histones. Nonetheless, recent studies suggest that tissues such as the gut can utilize butyrate as a metabolite. We have previously shown that the addition of butyrate induces a rapid increase of oxygen consumption in whole Drosophila melanogaster heads.

Seroprevalence of hepatitis B among the general population in Shandong Province, Eastern China, an update 30 years after the implementation of the neonatal vaccination program.

Background: In 1992, Hepatitis B vaccine was first recommended for routine neonatal immunization in China. This study aimed to estimate the prevalence of hepatitis B virus (HBV) infection in Shandong Province, eastern China (updating our previous study in 2014), and to help guide the efforts of hepatitis B elimination.

Methods: We determined prevalence of HBV infection from the remaining serum samples collected through a population-based survey, which was originally intended for a seroepidemiological survey of anti-SARS-CoV-2 antibodies conducted in 2023.

Effect of exercise on physical fitness and quality of life in patients with pulmonary embolism: a systematic review and meta-analysis.

Background: Pulmonary embolism (PE) survivors frequently experience persistent dyspnea and diminished quality of life (QoL). Evidence suggests that rehabilitation exercise has a positive impact on QoL, physical fitness, and dyspnea in patients with heart disease and chronic obstructive pulmonary disease. However, the effects of exercise on patients with PE remain ambiguous.

Identification of BCL3 as a biomarker for chondrocyte programmed cell death in osteoarthritis.

Osteoarthritis (OA) is a condition that is widely prevalent and causes joint pain and disability, with programmed cell death (PCD) playing a role in its pathogenesis. This study aimed to identify biomarkers associated with PCD in OA and explore their potential roles. Three RNA-sequencing datasets (GSE114007, GSE51588 and GSE220243) related to OA were analysed.

Precise Cell Type Electrical Stimulation Therapy Via Force-electric Hydrogel Microspheres for Cartilage Healing.

Electrical stimulation enhances cellular activity, promoting tissue regeneration and repair. However, specific cells and maintaining a stable energy supply are challenges for precise cell electrical stimulation therapy. Here, force-electric conversion hydrogel microspheres (Piezo@CR MPs) is devloped to induce specific stem cell aggregation and promote chondrogenic differentiation through localized electrical stimulation.

A Demethylation-Switchable Aptamer Design Enables Lag-Free Monitoring of mA Demethylase FTO with Energy Self-Sufficient and Structurally Integrated Features.

Cellular context profiling of modification effector proteins is critical for an in-depth understanding of their biological roles in RNA -methyladenosine (mA) modification regulation and function. However, challenges still remain due to the high context complexities, which call for a versatile toolbox for accurate live-cell monitoring of effectors. Here, we propose a demethylation-switchable aptamer sensor engineered with a site-specific mA (DSA-mA) for lag-free monitoring of the mA demethylase FTO activity in living cells.

Pectinesterase activity and gene expression correlate with pathogenesis of .

Late blight caused by is the most devastating disease of potato. produces many secondary metabolites and effector proteins, involved in the pathogenesis, which compromise host defense mechanisms. Pectinesterase (PE) is a cell wall degrading enzyme secreted by to infect the host.

Impact on Ant Communities by Chemical Pesticides Applied in Controlling the Red Imported Fire Ant ( Buren) in the Field.

The red imported fire ant (RIFA, Buren) represents a significant invasive pest in China, exerting extensive negative impacts on ecosystems. The invasion of RIFA not only poses a severe threat to biodiversity within the environment; inappropriate controlling measures can also adversely affect community dynamics. Therefore, while implementing effective management strategies to control the proliferation of RIFA populations, it is imperative to evaluate the potential effects of these measures on the structure of local biological communities to safeguard native biodiversity.

C1q/tumor necrosis factor-related protein-6 suppresses the angiotensin II-induced differentiation of cardiac fibroblasts to myofibroblasts via activation of the AMPK pathway.

C1q/tumor necrosis factor-related protein-6 (CTRP6) has multiple protective effects against cardiovascular diseases. Myofibroblast differentiation plays a critical role in cardiac fibrosis under various cardiac pathological conditions. The aim of the present study was to determine the effects of CTRP6 on cardiac fibrosis, and to identify the possible mechanisms of action.

A comparative study on the stability and coagulation removal of aged vs. nonaged nanoplastics in surface water.

Nanoplastics (NPs) are released into surface water due to the widespread use of plastics, undergoing aging from environmental and human factors that alter their physical and chemical characteristics. However, detecting NPs remains challenging, resulting in limited research on their behavior in surface water and their removal efficiency by drinking water treatment. This study utilizes palladium-doped polystyrene nanoplastics (PSNPs) as tracers to enable precise detection and quantification through ICP-MS, thereby overcoming the limitations of conventional detection methods.

Global Disease Burden Attributable to High Body Mass Index in Young Adults From 1990 to 2019, With Projections to 2050: A Systematic Analysis for the Global Burden of Disease Study 2019.

Aims: The global historical and projected health impacts of the escalating burden of obesity on young adults, who are particularly susceptible to weight gain during transitional life stages, remain insufficiently understood.

Materials And Methods: Using data from the Global Burden of Disease Study 2019, we analysed the disability-adjusted life-years (DALYs) and deaths attributable to high body mass index (BMI) among young adults aged 20-44 years globally and by age, sex, year, location and disease between 1990 and 2019. Future projections until 2050 were further assessed.

Safety of herbal medicines used in early gestations among the Chinese population: A population-based cohort study.

Background: Herbal medicines have a long history of use for pregnant women around the world. However, their use in the early pregnancy is often questioned in terms of safety on offspring.

Purpose: To investigate whether herbal medicines used at early pregnancy are associated with an increased risk of birth defects.

Model-based characterization of total serum bilirubin dynamics in preterm infants.

Objectives: This study aims to characterize the age-related natural dynamics of total serum bilirubin (TSB) in preterm infants through a mathematical model and to study the model parameters as potential biomarkers for detecting associated morbidities.

Methods: We proposed an exponential decay model and applied it to each infant. Patient-specific parameters were obtained by minimizing the error between measured TSB and model output.

Causal associations between the insulin-like growth factor family and sarcopenia: a bidirectional Mendelian randomization study.

Objective: Insulin-like growth factor (IGF) is closely associated with sarcopenia, yet the causal relationship of this association remains unclear. This study aims to explore the potential causal relationship between members of the IGF family and sarcopenia from a genetic perspective through bidirectional Mendelian randomization (MR) analysis using two-sample datasets.

Methods: Five genetically predicted factors of the IGF family (IGF-1, IGF-1R, IGF-2R, IGFBP-3, IGFBP-7) as one sample, while four relevant features of sarcopenia (low hand grip strength, appendicular lean mass, whole body fat-free mass, and walking pace) as another sample, in conducting a two-sample MR analysis.