The regulatory network that controls lymphopoiesis.

Lymphopoiesis is the generation of the T, B and NK cell lineages from a common lymphoid-biased haematopoietic stem cell. The experimental study of this process has generated a large amount of cellular and molecular data. As a result, there is a considerable number of mathematical and computational models regarding different aspects of lymphopoiesis.

High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study.

Background: Preliminary evaluations of 212 drinking offspring from the San Diego Prospective Study (SDPD) indicated that over 50% developed alcohol use disorder (AUD) by their mid-20s. The present analysis evaluated if those findings remained robust when the group increased to 454 individuals, a sample size that facilitated a search for potential contributors to the high AUD prevalence.

Methods: Semistructured interviews were used to evaluate lifetime AUD diagnoses in 224 daughters and 230 sons from the SDPS (N = 454) by mean age 26.

Recognition of static and dynamic emotional facial expressions in mild cognitive impairment, healthy elderly and young people.

Introduction: The ability to recognize emotions is essential for social cognition, and its impairment can affect social interactions, contributing to loneliness and the worsening of issues in individuals with mild cognitive impairment (MCI). This study aims to investigate the ability to recognize emotional facial expressions in MCI individuals compared to healthy elderly and young individuals.

Method: We evaluated 27 MCI individuals, 31 healthy elderly, and 29 healthy young participants using two tasks: one with static facial expressions (photographs) and another with dynamic ones (video clips).

Geographical distribution of human pythiosis in the USA.

For more than 100 years, the infections caused by have been well documented in horses. However, recently, pythiosis was also described in several species, including dogs, cats, cattle, zoo captive animals, and humans. Human pythiosis is a life-threatening infection requiring an early diagnosis for a successful management.

Cognitive outcomes after magnetic resonance-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy in adolescent patients.

Surgical treatment of medication-resistant mesial temporal lobe epilepsy (MTLE) is associated with cognitive deficits. Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) for MTLE has been shown to result in superior cognitive outcomes in adults when compared to open surgical resection. However, data regarding postoperative cognitive outcomes in adolescent and pediatric patients is limited.

Impact of knowledge of HPV positivity on cervical cytology performance in latin america.

Background: Cervical cytology is recommended by WHO as a triage option in HPV-based cervical cancer screening programmes. We assessed the performance of cytology to detect CIN3+ without and with knowledge of HPV positivity.

Methods: Women were screened with cytology and HPV across ESTAMPA study centres in Latin America.

Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology.

Medically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal pathogens complete their life cycle in environmental habitats or occur as commensals within or on the vertebrate body, but under certain conditions can thrive upon infecting humans. The extent of host damage in opportunistic infections largely depends on the portal and modality of entry as well as on the host's immune and metabolic status.

The Proteomics Standards Initiative Standardized Formats for Spectral Libraries and Fragment Ion Peak Annotations: mzSpecLib and mzPAF.

Mass spectral libraries are collections of reference spectra, usually associated with specific analytes from which the spectra were generated, that are used for further downstream analysis of new spectra. There are many different formats used for encoding spectral libraries, but none have undergone a standardization process to ensure broad applicability to many applications. As part of the Human Proteome Organization Proteomics Standards Initiative (PSI), we have developed a standardized format for encoding spectral libraries, called mzSpecLib (https://psidev.

Genital infections in high-risk human papillomavirus positive Paraguayan women aged 30-64 with and without cervical lesions.

Objective: To determine the prevalence of genital infections (GIs), including sexual transmitted STIs: Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, and opportunistic pathogens that generally do not cause STIs, non-classic STI: Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma hominis, in women with high-risk oncogenic human papillomavirus (hr-HPV) infection and their association with cervical lesions.

Methods: A cross-sectional study was carried out including 231 hr-HPV positive women. Of these, 46 has histologically confirmed cervical intraepithelial neoplasia 3 (CIN3) or more (including CIN3 and cervical cancer lesions-CIN3+).

Mechanical properties of dual-polymerizing resin-core material, dual-polymerizing resin cement, and bulk-fill composite resin used for restoring endodontically treated teeth.

Statement Of Problem: How resin-based material and a light-activation protocol influence the mechanical properties of materials used to cement glass fiber post-and-cores in endodontically treated teeth is unclear.

Purpose: The purpose of this in vitro study was to evaluate the influence of immediate or 5-minute delayed light activation on the mechanical properties of dual-polymerizing resin cements and dual-polymerizing resin-core materials compared with bulk-fill composite resins.

Material And Methods: Nine resin-based materials were tested: 4 dual-polymerizing resin-core materials, (Allcem Core; FGM, LuxaCore Z; DMG, Rebilda DC; VOCO, and (Clearfil DC Core Plus; KURARAY), 3 dual-polymerizing resin cements, (RelyX Universal; 3M ESPE, RelyX U200; 3M ESPE, and Allcem Dual; FGM), and 2 bulk-fill composite resins, (Opus Bulk Fill APS; FGM, and Filtek One Bulk Fill; 3M ESPE).

Morphological Differentiation, Yield, and Cutting Time of L. under Acid Soil Conditions in Highlands.

Livestock production in the basins of the northern macro-region of Peru has as its primary source pastures of L. 'Cajamarquino ecotype' (ryegrass CE) in monoculture, or in association with white clover Ladino variety, for feeding. The objective of this research work was the morphological characterisation, yield evaluation, and cutting time evaluation of two local genotypes (LM-58 and LM-43) of L.

Functional measures and AD biomarkers among Hispanic and White non-Hispanic older adults.

Introduction: Poorer baseline functioning is associated with long-term cognitive decline among Hispanic older adults, but little is known about associations of these factors with Alzheimer's disease (AD) neuroimaging biomarkers.

Methods: A total of 461 Hispanic and White non-Hispanic (NHW) older adults who are cognitively normal ( = 76), had impaired cognition without mild cognitive impairment (MCI) ( = 41), or carried a diagnosis of MCI ( = 253) or dementia ( = 91) completed neuropsychological and functional assessment, genetic testing, and brain magnetic resonance imaging (MRI). Structural equation modeling (SEM) was used to examine predictive associations between functional and cognitive measures of AD neuroimaging biomarkers.

The PeptideAtlas: A New Maize Community Resource.

This study presents the Maize PeptideAtlas resource (www.peptideatlas.org/builds/maize) to help solve questions about the maize proteome.

Pivoting COVID-19 Resources for an Equitable Mpox Vaccine Response in Louisiana.

Introduction: The first case of mpox in Louisiana was identified 2 months ahead of Southern Decadence Festival in New Orleans, the largest LGBTQ+ Pride festival in the South. With mpox case numbers reflecting racial disparities, the objective was to mount an equitable vaccination response.

Methods: The Louisiana Department of Health rapidly pivoted its COVID-19 resources and strategies-specifically, using vaccine strike teams and mobile events, in-state vaccine redistribution through centralized warehousing and shipping support, and community partnerships-to now control mpox transmission.

Within-host influenza viral diversity in the pediatric population as a function of age, vaccine, and health status.

Seasonal influenza virus predominantly evolves through antigenic drift, marked by the accumulation of mutations at antigenic sites. Because of antigenic drift, influenza vaccines are frequently updated, though their efficacy may still be limited due to strain mismatches. Despite the high levels of viral diversity observed across populations, most human studies reveal limited intrahost diversity, leaving the origin of population-level viral diversity unclear.

[Strategies for the prevention and non-pharmacological treatment of obesity. Models of care].

The prevalence of obesity has increased in recent years worldwide. In this context, strategies for management obesity in primary care are essential. The first step in the treatment of obesity are lifestyle intervention programs.

Multisensor Magnetic Scanning Microscope for Remanent Magnetic Field Measurements.

Magnetic Scanning Microscopy (MSM) emerged with the aim of allowing the visualization of magnetic fields of a sample or material through scanning and proved particularly useful for geology, biomedicine, characterization of magnetic materials, and in the steel industry. In this regard, the reading system of an MSM was modified using a μ-metal magnetic shielding structure to analyze remanent fields. The MSM was adapted to perform readings using two different types of sensors.

Itraconazole in human medicine and veterinary practice.

Diagnosis and management of fungal infections are challenging in both animals and humans, especially in immunologically weakened hosts. Due to its broad spectrum and safety profile when compared to other antifungals, itraconazole (ITZ) has been widely used in the treatment and prophylaxis of fungal infections, both in human and veterinary medicine. The dose and duration of management depend on factors such as the type of fungal pathogen, the site of infection, sensitivity to ITZ, chronic stages of the disease, the health status of the hosts, pharmacological interactions with other medications and the therapeutic protocol used.

Bacteremia associated with non-tunneled central venous catheters in children undergoing chronic hemodialysis.

Introduction. Central venous catheter (CVC)-related infection is the main complication observed in patients undergoing hemodialysis with this type of venous access. Objective.

Latent Trajectories of Persistence of Cannabis Use Across Four Decades in 329 Men From the San Diego Prospective Study.

Objective: These analyses use data from a 40-year prospective study to extend information into the sixth and seventh decades of life regarding latent trajectory classes of cannabis use and predictors of those classes.

Method: Data from the San Diego Prospective Study were analyzed for 329 men of European and Hispanic ethnicity who had used cannabis at about age 23 at study entry (Time 1) and who were interviewed about every 5 years through about age 60 to 70. Latent classes of cannabis use trajectories were evaluated using latent class growth analyses, baseline predictors of class membership were determined, and significant predictors of each class were established using logistic regression analyses.