Sex differences in the adrenal circadian clock: a role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice.

Brain and muscle ARNT-Like 1 (BMAL1) is a circadian clock transcription factor that regulates physiological functions. Male adrenal-specific () KO mice displayed blunted serum corticosterone rhythms, altered blood pressure rhythm, and altered timing of eating, but there is a lack of knowledge in females. This study investigates the role of adrenal BMAL1 in renal electrolyte handling and urinary aldosterone levels in response to low salt in male and female mice.

Dynamic redundancy as a mechanism to optimize collective random searches.

We explore the case of a group of random walkers looking for a target randomly located in space, such that the number of walkers is not constant but new ones can join the search, or those that are active can abandon it, with constant rates r_{b} and r_{d}, respectively. Exact analytical solutions are provided both for the fastest-first-passage time and for the collective time cost required to reach the target, for the exemplifying case of Brownian walkers with r_{d}=0. We prove that even for such a simple situation there exists an optimal rate r_{b} at which walkers should join the search to minimize the collective search costs.

Spatiotemporal organization of ant foraging from a complex systems perspective.

We use complex systems science to explore the emergent behavioral patterns that typify eusocial species, using collective ant foraging as a paradigmatic example. Our particular aim is to provide a methodology to quantify how the collective orchestration of foraging provides functional advantages to ant colonies. For this, we combine (i) a purpose-built experimental arena replicating ant foraging across realistic spatial and temporal scales, and (ii) a set of analytical tools, grounded in information theory and spin-glass approaches, to explore the resulting data.

Sociodemographic and Lifestyle Characteristics Associated with Maternal Dietary Patterns in Mexico.

There is scarce evidence on sociodemographic and lifestyle characteristics that may explain adherence to different dietary patterns (DPs) during pregnancy. Our aims were to identify dietary patterns in a sample of pregnant Mexican women and to describe their association with selected sociodemographic and lifestyle characteristics. This is a secondary cross-sectional analysis of 252 mothers of children that participated as controls in a hospital-based case-control study of childhood leukemia.

Highly pathogenic avian influenza H5N1 virus infections in pinnipeds and seabirds in Uruguay: Implications for bird-mammal transmission in South America.

The highly pathogenic avian influenza viruses of clade 2.3.4.

First-passage time of a Brownian searcher with stochastic resetting to random positions.

We study the effect of a resetting point randomly distributed around the origin on the mean first-passage time of a Brownian searcher moving in one dimension. We compare the search efficiency with that corresponding to reset to the origin and find that the mean first-passage time of the latter can be larger or smaller than the distributed case, depending on whether the resetting points are symmetrically or asymmetrically distributed. In particular, we prove the existence of an optimal reset rate that minimizes the mean first-passage time for distributed resetting to a finite interval if the target is located outside this interval.

Intermittent random walks under stochastic resetting.

We analyze a one-dimensional intermittent random walk on an unbounded domain in the presence of stochastic resetting. In this process, the walker alternates between local intensive search, diffusion, and rapid ballistic relocations in which it does not react to the target. We demonstrate that Poissonian resetting leads to the existence of a non-equilibrium steady state.

The long-chain flavodoxin FldX1 improves the biodegradation of 4-hydroxyphenylacetate and 3-hydroxyphenylacetate and counteracts the oxidative stress associated to aromatic catabolism in Paraburkholderia xenovorans.

Background: Bacterial aromatic degradation may cause oxidative stress. The long-chain flavodoxin FldX1 of Paraburkholderia xenovorans LB400 counteracts reactive oxygen species (ROS). The aim of this study was to evaluate the protective role of FldX1 in P.

Ergodic properties of Brownian motion under stochastic resetting.

We study the ergodic properties of one-dimensional Brownian motion with resetting. Using generic classes of statistics of times between resets, we find respectively for thin- or fat-tailed distributions the normalized or non-normalized invariant density of this process. The former case corresponds to known results in the resetting literature and the latter to infinite ergodic theory.

Random Walks on Comb-like Structures under Stochastic Resetting.

We study the long-time dynamics of the mean squared displacement of a random walker moving on a comb structure under the effect of stochastic resetting. We consider that the walker's motion along the backbone is diffusive and it performs short jumps separated by random resting periods along fingers. We take into account two different types of resetting acting separately: global resetting from any point in the comb to the initial position and resetting from a finger to the corresponding backbone.

Male kidney-specific BMAL1 knockout mice are protected from K-deficient, high-salt diet-induced blood pressure increases.

The circadian clock protein basic helix-loop-helix aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) is a transcription factor that impacts kidney function, including blood pressure (BP) control. Previously, we have shown that male, but not female, kidney-specific cadherin Cre-positive BMAL1 knockout (KS-BMAL1 KO) mice exhibit lower BP compared with littermate controls. The goal of this study was to determine the BP phenotype and immune response in male KS-BMAL1 KO mice in response to a low-K high-salt (LKHS) diet.

Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.

Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription factor that regulates many physiological functions, including blood pressure (BP). Male global knockout (KO) mice exhibit ∼10 mmHg reduction in BP, as well as a blunting of BP rhythm. The mechanisms of how BMAL1 regulates BP remains unclear.

Informational Entropy Threshold as a Physical Mechanism for Explaining Tree-like Decision Making in Humans.

While approaches based on physical grounds (such as the drift-diffusion model-DDM) have been exhaustively used in psychology and neuroscience to describe perceptual decision making in humans, similar approaches to complex situations, such as sequential (tree-like) decisions, are still scarce. For such scenarios that involve a reflective prospection of future options, we offer a plausible mechanism based on the idea that subjects can carry out an internal computation of the uncertainty about the different options available, which is computed through the corresponding Shannon entropy. When the amount of information gathered through sensory evidence is enough to reach a given threshold in the entropy, this will trigger the decision.

EMG-driven shared human-robot compliant control for in-hand object manipulation in hand prostheses.

. The limited functionality of hand prostheses remains one of the main reasons behind the lack of its wide adoption by amputees. Indeed, while commercial prostheses can perform a reasonable number of grasps, they are often inadequate for manipulating the object once in hand.

Conditioned backward and forward times of diffusion with stochastic resetting: A renewal theory approach.

Stochastic resetting can be naturally understood as a renewal process governing the evolution of an underlying stochastic process. In this work, we formally derive well-known results of diffusion with resets from a renewal theory perspective. Parallel to the concepts from renewal theory, we introduce the conditioned backward B and forward F times being the times since the last and until the next reset, respectively, given that the current state of the system X(t) is known.

EMG Data Augmentation for Grasp Classification Using Generative Adversarial Networks.

Electromyography (EMG) has been used as an interface for the control of robotic hands for decades but with the improvement of embedded electronics and decoding algorithms, many applications are now envisaged by companies. Deep learning has shown the possibility to increase decoding performance but it requires large amounts of data to show its full capabilities. However, recording such amounts of EMG signals face several issues since recording hours of data from patients is very time-consuming and can result in muscle fatigue.

Analysis of macular carotenoids in the developing macaque retina: The timeline of macular pigment development.

In the mature retina, the components of the macular pigment, lutein (L), R,R-zeaxanthin (RRZ), R,S-zeaxanthin (RSZ, meso-zeaxanthin) are most concentrated in the central macula. L and RRZ are of dietary origin but RSZ is produced in situ from L. The relative proportions of L and Z isomers vary across the retina with eccentricity in the adult retina.

Effects of pair migratory behavior on breeding phenology and success in a partially migratory shorebird population.

In migratory systems, variation in individual phenology can arise through differences in individual migratory behaviors, and this may be particularly apparent in partial migrant systems, where migrant and resident individuals are present within the same population. Links between breeding phenology and migratory behavior or success are generally investigated at the individual level. However, for breeding phenology in particular, the migratory behaviors of each member of the pair may need to be considered simultaneously, as breeding phenology will likely be constrained by timing of the pair member that arrives last, and carryover effects on breeding success may vary depending on whether pair members share the same migratory behavior or not.

Nonstandard diffusion under Markovian resetting in bounded domains.

We consider a walker moving in a one-dimensional interval with absorbing boundaries under the effect of Markovian resettings to the initial position. The walker's motion follows a random walk characterized by a general waiting time distribution between consecutive short jumps. We investigate the existence of an optimal reset rate, which minimizes the mean exit passage time, in terms of the statistical properties of the waiting time probability.

Future teachers facing the use of technology for inclusion: A view from the digital competence.

Technologies provide a differential value to the training process, allowing for the generation of new environments, methodologies and resources that make it possible to attend to students in a more appropriate way. This potential is especially relevant in matters of inclusion, where technology is sometimes an indispensable element for learning. In this paper we explore the main advantages of the use of technology for the attention to diversity, taking into consideration the level of digital competence of future teachers and their perceptions regarding its use for the implementation of inclusive strategies.

Phase Transition in a Non-Markovian Animal Exploration Model with Preferential Returns.

We study a non-Markovian and nonstationary model of animal mobility incorporating both exploration and memory in the form of preferential returns. Exact results for the probability of visiting a given number of sites are derived and a practical WKB approximation to treat the nonstationary problem is developed. A mean-field version of this model, first suggested by Song et al.

Aerobic biotransformation of 6:2 fluorotelomer sulfonate by Dietzia aurantiaca J3 under sulfur-limiting conditions.

The polyfluorinated alkyl substance 6:2 fluorotelomer sulfonate (6:2 FTS) has been detected in diverse environments impacted by aqueous film-forming foams used for firefighting. In this study, a bacterial strain (J3) using 6:2 FTS as a sulfur source was isolated from landfill leachate previously exposed to polyfluoroalkyl substances in New South Wales, Australia. Strain J3 shares 99.

Gestational obesity: An unconventional endocrine disruptor for the fetus.

Obesity has reached pandemic proportions and is a growing concern throughout the world. A parallel trend has also been observed among women in reproductive age, leading to the increasing global prevalence of gestational obesity (GO). The well-known obesity-related health problems also extend to pregnancy, where they are responsible for giving rise to a variety of medical and obstetrical complications, resulting in an increased incidence of adverse maternal and fetal outcomes.

The OxyR and SoxR transcriptional regulators are involved in a broad oxidative stress response in Paraburkholderia xenovorans LB400.

Background: Aerobic metabolism generates reactive oxygen species that may cause critical harm to the cell. The aim of this study is the characterization of the stress responses in the model aromatic-degrading bacterium Paraburkholderia xenovorans LB400 to the oxidizing agents paraquat and HO.

Methods: Antioxidant genes were identified by bioinformatic methods in the genome of P.