Metformin-induced lactic acidosis: a case series.

Introduction: Unlike other agents used in the treatment of type 2 diabetes mellitus, metformin has been shown to reduce mortality in obese patients. It is therefore being increasingly used in higher doses. The major concern of many physicians is a possible risk of lactic acidosis.

The effect of discrete calcium phosphate nanocrystals on bone-bonding to titanium surfaces.

We sought to address the question: Can metallic surfaces be rendered bone-bonding? We employed dual acid-etched (DAE) commercially pure titanium (cpTi) and titanium alloy (Ti6Al4V) custom-made rectangular coupons (1.3 mm x 2.5 mm x 4 mm) with, or without, further modification by the discrete crystalline deposition (DCD) of calcium phosphate (CAP) nanocrystals.

Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile.

The thermophilic and halotolerant nature of Rubrobacter xylanophilus led us to investigate the accumulation of compatible solutes in this member of the deepest lineage of the Phylum Actinobacteria. Trehalose and mannosylglycerate (MG) were the major compounds accumulated under all conditions examined, including those for optimal growth. The addition of NaCl to a complex medium and a defined medium had a slight or negligible effect on the accumulation of these compatible solutes.

[Decompressive craniectomy for treatment of intracranial hypertension secondary to large ischemic cerebral infarction: analysis of 34 cases].

Unlabelled: The large ischemic cerebral infarction (LICI) is a blood supply loss of a large area in the brain, mainly on the middle cerebral artery. Is possible that evolutes a major edema, intracranial hypertension and death in about 80% of the cases.

Objective: To evaluate the results of a decompressive craniectomy on the treatment of the secondary intracranial hypertension to LICI, comparing to other results of medical literature already published.

[Transspheinoidal transpalatal meningoencephalocele].

Transspheinoidal meningoencephalocele is a rare presentation of dysraphism of the neural tube. It is characterized by the herniation of the neural tissue through a bony defect in the sphenoid bone. The clinical presentation is variable.

Bacillus foraminis sp. nov., isolated from a non-saline alkaline groundwater.

A low-G+C-content Gram-positive bacterium, designated CV53T, phylogenetically related to species of the genus Bacillus, was isolated from a highly alkaline non-saline groundwater environment (pH 11.4). This organism comprised rod-shaped cells, was aerobic, did not display spore formation, was catalase- and oxidase-negative, had an optimum growth temperature of 40 degrees C and had an optimum pH of approximately 7.

Chimaereicella alkaliphila gen. nov., sp. nov., a Gram-negative alkaliphilic bacterium isolated from a nonsaline alkaline groundwater.

A Gram-negative bacterium designated AC-74(T) was isolated from a highly alkaline groundwater environment (pH 11.4). This organism formed rod-shaped cells, is strictly aerobic, catalase and oxidase positive, tolerates up to 3.

Microcella putealis gen. nov., sp. nov., a gram-positive alkaliphilic bacterium isolated from a nonsaline alkaline groundwater.

Three Gram-positive bacteria designated CV-2T, CV-40 and AC-30 were isolated from a highly alkaline groundwater environment (pH 11.4). These organisms formed very small rod-shaped cells, are aerobic, non-spore-forming, catalase-positive, oxidase-negative, with an optimum growth temperature of 35 degrees C and optimum pH value of growth between 8.

Phenylobacterium falsum sp. nov., an Alphaproteobacterium isolated from a nonsaline alkaline groundwater, and emended description of the genus Phenylobacterium.

A Gram-negative bacterium designated AC-49T was isolated from an alkaline groundwater with a pH 11.4. This organism formed rod-shaped cells, was strictly aerobic, catalase and oxidase positive, with an optimum growth temperature of 35 degrees C and an optimum pH value of 8.

[Respiratory manifestations of malignant lymphomas: report of 5 cases].

In this study the authors report 5 cases of malignant lymphomas consisting in a Hodgkin's disease and 4 non Hodgkinian lymphomas. Patients aged from 16 to 55 years were 4 males and 1 female, consulting in Department of respiratory disorders of the University Hospital in Dakar, Senegal, West Africa, from 1986 thru 1992. Detoriation of the general status, cough, dyspnea and cervical adenopathy were remaked in all patients.

[Toxocological study of Guiera senegalensis Lam (Combretaceae)].

The study was based on an aqueous extract derived from a 60 degrees ethanolic tincture containing 0.032 g of dry matter per ml. The leaves of Guiera senegalensis Lam (Combretaceae) were collected in December 1991 at Nguekhokh a village within 20 km from Mbour (Senegal).

[3 cases of vulvar epidermal cysts after female genital mutilation].

We report three cases of tumors of the vulva following an excision during childhood, in patients aged 22 to 25. The achieved surgical removal gave correct aesthetic and functional results. Histological examination of these tumors revealed epidermal cyst containing keratin.

Development of a technique for using 99mTc as an adsorbable tracer for hydrodynamic studies of fine sediments in suspension.

Labelling of fine sediment (phi < 62.5 microm) with 99mTc was achieved through laboratory experiments described in a previous work (Proceedings of an International Symposium on Isotope Techniques in Water Resources Development and Management. IAEA-SM-361/13, Vienna, Proceedings of the XIIIth Brazilian Symposium on Water Resources.

[Vaginal injuries during coitus].

Based on a prospective study on a continuous series of women admitted on emergency for post-coitus hemorrhage. The authors present an epidemiology and prognosis of vaginal injuries in to coitus in the Dakar University Teaching Hospital. Over a period of 33 months (October 1991 to December 1994), 106 cases were recorded, giving an incidence rate of 32 cases per year.

[Gestational trophoblastic tumors: epidemiology and prognosis in Dakar University teaching hospital].

From a prospective and length wise survey, the forecast of the gestational trophoblastics tumours was estimated. Between 1st November 1996 and 31st October 1997, 102 cases of gestational trophoblastics tumours was registered. The medium profile was a "Ouoloff" (54%) or "Serere" (20%), 30 years old, multiparous, without, security social cover (100%).

Intraosseous leiomyoma of the mandible.

An intraosseous leiomyoma arising within the mandible was diagnosed in a 24-year-old woman. Clinically, a nodular swelling of the lower border of the mandible was noted. Radiographically, a unilocular ellipsoid radiolucency, loss of the lower border of the mandible, and tooth resorption were observed.

Neurologic manifestations of AIDS: a review of fifty cases in Santos, São Paulo, Brazil.

Objective: To review the neurologic manifestations of AIDS in patients who were admitted to Hospital Guilherme Alvaro (HGA) due to any clinical manifestation of the disease.

Design: Case series.

Patients: All HIV+ patients admitted to the Faculty Hospital (HGA) between July 96 and April 97 were included in this review.

[Severe thrombocytopenia associated with Abciximab therapy--apropos a clinical case].

The authors present the case of a 52-year-old male patient with severe coronary artery disease, submitted to percutaneous transluminal coronary angioplasty on a type C right coronary artery lesion. The use of a platelet glycoprotein receptor IIb-IIIa inhibitor, Abciximab, led to severe thrombocytopenia, treated only with platelet concentrate transfusions and with complete recovery. We also review the principal characteristics of the drug, its main indications and side effects.

[The diagnostic and prognostic value of the 12-lead electrocardiogram in assessing the severity of coronary disease in the acute phase of an acute myocardial infarct].

Unlabelled: The conventional twelve-lead electrocardiogram (ECG) still is the cheapest, most used and absolutely essential diagnostic method for the acute phase of myocardial infarction (MI) allowing risk stratification and coronary prognostic evaluation in this phase mainly by the localization of the ST segment depression and/or T wave inversion (ST/T changes) not related to the infarct area in Q-Wave MI or at any localization in case of non-Q wave MI. The etiology and pathophysiology of these ST/T changes in the setting of MI has been controversial. With the objective of determining ECG prognostic and diagnostic value, 70 patients (Pts) (59 men and 11 women, mean age 58 + 13) admitted in the acute phase of MI were studied with revision of acute phase ECG ST/T changes.

Assessment of the efficacy of diethylcarbamazine on adult Wuchereria bancrofti in vivo.

To assess directly the effect of various doses of diethylcarbamazine (DEC) on adult Wuchereria bancrofti, 31 infected men were randomly assigned to receive an initial single DEC dose of 1 mg/kg (n = 7), 6 mg/kg (n = 10), or 12 mg/kg (n = 14). Beginning 7 d later, the dosage of DEC and duration of treatment were progressively increased for 7-10 weeks. Physical examinations were performed to detect scrotal nodules and the scrotal area was examined by ultrasound (7.

[Keratosis diffusa fetalis. Apropos of 2 cases].

Keratosis diffusa fetalis is a rare autosomic recessive disorder, in which infants are covered with large parchment-like scales, split by deep fissures. Most affected infants die a few weeks after birth because of infections and respiratory problems. The authors present the clinical, histological and ultrastructural aspects of two cases of Ichthyosis congenita fetalis observed in negro-African newborns.

[Epidemiological and anatomo-clinical features of extra-uterine pregnancies at the Dakar University Hospital Center].

It is the prospective study of 226 cases of operated ectopic pregnancies, in order to draw the epidemiological outline of such an affliction adn find out the possible etiologies. During this study, 107 swabs were anatomically exploited. An analysis of the results reveals the high frequency of disrupted ectopic pregnancies (over 90%).

Isolation and preliminary characterization of a caprine rotavirus.

Five cytopathic rotavirus strains were isolated in MA104 cells from stool specimens of kids with diarrhoea. Pre-treatment of the virus with trypsin and incorporation of low levels of trypsin in the maintenance medium were important for the successful cultivation of the strains in these cells. The isolates were shown to be group A rotaviruses by antigenic reactivity with a group A monoclonal antibody.