Temperature mapping of milling by dual centrifugation: A systematic investigation.

Using low quantities of drug compounds is often favorable in the early stages of drug development, especially for what require a large screening investigation to define the final formulation composition, such as nano- and microsuspensions. For that reason, the dual centrifugation approach has in the recent years been used due to its reproducible and fast-milling capacity with 40 samples in 2 mL vials simultaneously without the addition of cooling breaks due to a built-in cooling system. Nonetheless, heat can be dissipated into the samples during high-intensity milling, resulting in increased sample temperatures that potentially can affect thermolabile compounds and potential influence the obtained suspensions in the screening experiments if the used stabilizer has temperature dependent variations in the performance.

Generative preparation tasks in digital collaborative learning: actor and partner effects of constructive preparation activities on deep comprehension.

Deep learning from collaboration occurs if the learner enacts interactive activities in the sense of leveraging the knowledge externalized by co-learners as resource for own inferencing processes and if these interactive activities in turn promote the learner's deep comprehension outcomes. This experimental study investigates whether inducing dyad members to enact constructive preparation activities can promote deep learning from subsequent collaboration while examining prior knowledge as moderator. In a digital collaborative learning environment, 122 non-expert university students assigned to 61 dyads studied a text about the human circulatory system and then prepared individually for collaboration according to their experimental conditions: the preparation tasks varied across dyads with respect to their generativity, that is, the degree to which they required the learners to enact constructive activities (note-taking, compare-contrast, or explanation).

Electronic Heart (ECG) Monitoring at Birth and Newborn Resuscitation.

Background: Approximately 10% of newborns require assistance at delivery, and heart rate (HR) is the primary vital sign providers use to guide resuscitation methods. In 2016, the American Heart Association (AHA) suggested electrocardiogram in the delivery room (DR-ECG) to measure heart rate during resuscitation. This study aimed to compare the frequency of resuscitation methods used before and after implementation of the AHA recommendations.

In Flight Performance of the Far Ultraviolet Instrument (FUV) on ICON.

The NASA Ionospheric Connection Explorer (ICON) was launched in October 2019 and has been observing the upper atmosphere and ionosphere to understand the sources of their strong variability, to understand the energy and momentum transfer, and to determine how the solar wind and magnetospheric effects modify the internally-driven atmosphere-space system. The Far Ultraviolet Instrument (FUV) supports these goals by observing the ultraviolet airglow in day and night, determining the atmospheric and ionospheric composition and density distribution. Based on the combination of ground calibration and flight data, this paper describes how major instrument parameters have been verified or refined since launch, how science data are collected, and how the instrument has performed over the first 3 years of the science mission.

Neutral Composition Information in ICON EUV Dayglow Observations.

Since the earliest space-based observations of Earth's atmosphere, ultraviolet (UV) airglow has proven a useful resource for remote sensing of the ionosphere and thermosphere. The NASA Ionospheric Connection Explorer (ICON) spacecraft, whose mission is to explore the connections between ionosphere and thermosphere utilizes UV airglow in the typical way: an extreme-UV (EUV) spectrometer uses dayglow between 54 and 88 nm to measure the density of O, and a far-UV spectrograph uses the O 135.6 nm doublet and N Lyman-Birge-Hopfield band dayglow to measure the column ratio of O to N in the upper thermosphere.

Effects of Subauroral Polarization Streams on the Upper Thermospheric Winds During Non-Storm Time.

Intense sunward (westward) plasma flows, named Subauroral Polarization Stream (SAPS), have been known to occur equatorward of the electron auroras for decades, yet their effect on the upper thermosphere has not been well understood. On the one hand, the large velocity of SAPS results in large momentum exchange upon each ion-neutral collision. On the other hand, the low plasma density associated with SAPS implies a low ion-neutral collision frequency.

First ICON-FUV Nighttime NmF2 and hmF2 Comparison to Ground and Space-Based Measurements.

The Far Ultra Violet (FUV) ultraviolet imager onboard the NASA-ICON mission is dedicated to the observation and study of the ionosphere dynamics at mid and low latitudes. We compare O density profiles provided by the ICON FUV instrument during nighttime with electron density profiles measured by the COSMIC-2 constellation (C2) and ground-based ionosondes. Co-located simultaneous observations are compared, covering the period from November 2019 to July 2020, which produces several thousands of coincidences.

First results from the retrieved column O/N ratio from the Ionospheric Connection Explorer (ICON): Evidence of the impacts of nonmigrating tides.

In near-Earth space, variations in thermospheric composition have important implications for thermosphere-ionosphere coupling. The ratio of O to N is often measured using far-UV airglow observations. Taking such airglow observations from space, looking below the Earth's limb allows for the total column of O and N in the ionosphere to be determined.

Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.

Clinical trials for MET inhibitors have demonstrated limited success for their use in colon cancer (CC). However, clinical efficacy may be obscured by a lack of standardisation in MET assessment for patient stratification. In this study, we aimed to determine the molecular context in which MET is deregulated in CC using a series of genomic and proteomic tests to define MET expression and identify patient subgroups that should be considered in future studies with MET-targeted agents.

Extracranial Stereotactic Body Radiotherapy in Oligometastatic or Oligoprogressive Breast Cancer.

Oligometastatic disease (OMD) and oligoprogressive disease (OPD) describe tumor states with a limited metastasization. In contrast to other disease states, treatment of OMD or OPD has not yet become common for breast cancer. We sought to understand the outcomes and toxicities of this treatment paradigm.

Age-dependent hemato- and nephrotoxicity in patients with head and neck cancer receiving chemoradiotherapy with weekly cisplatin.

Background And Purpose: In cases of simultaneous chemoradiotherapy (CRT), early recognition of toxic side effects is important, as drug discontinuation may prevent further injury. It appears favorable to undertake further steps to investigate whether patient subgroups behave differently depending on their toxicity profile.

Methods: We retrospectively analyzed 125 consecutive patients with non-metastasized carcinoma of the head and neck who were treated with CRT (cisplatin 40 mg/m weekly) in 2013/2014.

Rapid development of API nano-formulations from screening to production combining dual centrifugation and wet agitator bead milling.

Various wet ball nanomilling-screening tools for poorly soluble APIs are available which differ in their milling principle, batch size and number of samples. Here, the transferability of results from screening (small to medium-scale) to pharmaceutical production (largescale) was investigated. Wet ball milling in a dual centrifuge (DC) (10-100 mg API, 40 samples in parallel) was used to identify stable nanoformulations.

Clustering of Strains to Establish a Relation between Exopolysaccharide Characteristics and Gel Properties of Acidified Milk.

In situ produced extracellular polysaccharides (EPS) from lactic acid bacteria are generally known to affect the texture of fermented dairy products; however, the interplay between EPS and product properties is still poorly understood. The aim of this study was to establish a relationship between concentration and properties of EPS, and gel formation of milk analysed by noninvasive Multispeckle Diffusing Wave Spectroscopy. Twenty strains were classified with respect to EPS concentration (8-126 mg GE/kg) and ropiness (thread length: 15-80 mm).

Michelson Interferometer for Global High-resolution Thermospheric Imaging (MIGHTI): Monolithic Interferometer Design and Test.

The design and laboratory tests of the interferometers for the Michelson Interferometer for Global High-resolution Thermospheric Imaging (MIGHTI) instrument which measures thermospheric wind and temperature for the NASA-sponsored Ionospheric Connection (ICON) Explorer mission are described. The monolithic interferometers use the Doppler Asymmetric Spatial Heterodyne (DASH) Spectroscopy technique for wind measurements and a multi-element photometer approach to measure thermospheric temperatures. The DASH technique and overall optical design of the MIGHTI instrument are described in an overview followed by details on the design, element fabrication, assembly, laboratory tests and thermal control of the interferometers that are the heart of MIGHTI.

Daytime O/N Retrieval Algorithm for the Ionospheric Connection Explorer (ICON).

The NASA Ionospheric Connection Explorer Far-Ultraviolet spectrometer, ICON FUV, will measure altitude profiles of the daytime far-ultraviolet (FUV) OI 135.6 nm and N Lyman-Birge-Hopfield (LBH) band emissions that are used to determine thermospheric density profiles and state parameters related to thermospheric composition; specifically the thermospheric column O/N ratio (symbolized as ΣO/N). This paper describes the algorithm concept that has been adapted and updated from one previously applied with success to limb data from the Global Ultraviolet Imager (GUVI) on the NASA Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) mission.

Michelson Interferometer for Global High-resolution Thermospheric Imaging (MIGHTI): Instrument Design and Calibration.

The Michelson Interferometer for Global High-resolution imaging of the Thermosphere and Ionosphere (MIGHTI) instrument was built for launch and operation on the NASA Ionospheric Connection Explorer (ICON) mission. The instrument was designed to measure thermospheric horizontal wind velocity profiles and thermospheric temperature in altitude regions between 90km and 300km, during day and night. For the wind measurements it uses two perpendicular fields of view pointed at the Earth's limb, observing the Doppler shift of the atomic oxygen red and green lines at 630.

Inferring Nighttime Ionospheric Parameters With the Far Ultraviolet Imager Onboard the Ionospheric Connection Explorer.

The Ionospheric Connection Explorer (ICON) Far Ultraviolet (FUV) imager, ICON FUV, will measure altitude profiles of OI 135.6 nm emissions to infer nighttime ionospheric parameters. Accurate estimation of the ionospheric state requires the development of a comprehensive radiative transfer model from first principles to quantify the effects of physical processes on the production and transport of the 135.

The Ionospheric Connection Explorer Mission: Mission Goals and Design.

The Ionospheric Connection Explorer, or ICON, is a new NASA Explorer mission that will explore the boundary between Earth and space to understand the physical connection between our world and our space environment. This connection is made in the ionosphere, which has long been known to exhibit variability associated with the sun and solar wind. However, it has been recognized in the 21st century that equally significant changes in ionospheric conditions are apparently associated with energy and momentum propagating upward from our own atmosphere.

Shear treatment of starter culture medium improves separation behavior of cells.

A central step in the production of starter cultures is the separation of the cells from the fermentation medium, which is usually achieved by disk centrifuges. In case of microorganisms which produce exopolysaccharides (e.g.

Time-Delay Integration Imaging with ICON's Far-Ultraviolet Imager.

A Time-Delay Integration (TDI) image processing system has been developed to capture ICON's Far Ultraviolet (FUV) Spectrographic Imager data. The TDI system is designed to provide variable-range motion-compensated imaging of Earth's nightside ionospheric limb and sub-limb scenes viewed from Low Earth Orbit in the 135.6 nm emission of oxygen with an integration time of 12 seconds.

The Far Ultra-Violet imager on the ICON mission.

ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime atmosphere/ionosphere. During sunlit atmospheric conditions, ICON FUV images the limb altitude profile in the shortwave (SW) band at 135.6 nm and the longwave (LW) band at 157 nm perpendicular to the satellite motion to retrieve the atmospheric O/N ratio.

Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors.

Background/aims: The tumor suppressor p53 is rarely mutated in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) but they frequently show a strong expression of negative regulators of p53, rendering these tumors excellent targets for a p53 recovery therapy. Therefore, we analyzed the mechanisms of a p53 recovery therapy on intestinal neuroendocrine tumors in vitro and in vivo.

Methods: By Western blot and immunohistochemistry, we found that in GEP-NEN biopsy material overexpression of MDM2 was present in intestinal NEN.

Does Survival Vary for Breast Cancer Patients in the United States? A Study from Six Randomly Selected States.

Background: Breast cancer is the most common cancer in women. Disparities in some characteristics of breast cancer patients and their survival data for six randomly selected states in the US were examined.

Materials And Methods: A probability random sampling method was used to select the records of 2,000 patients from each of six randomly selected states.