Four new species of Fallén (Hemiptera, Miridae) from the Davis Mountains in Texas and further documentation of known species of Jeff Davis County.

A recent survey of the entomofauna of the Davis Mountains in the state of Texas has revealed four new species in the genus Fallén (Miridae, Mirinae, Mirini): and found on Liebmann, and and found attracted to lights. Descriptions, habitus, and genitalic images for the new species are included herein. Further, habitus and genitalic photographs of known species from the county are included to aid in identification.

Complete Genome Sequences and Characteristics of Seven Novel Mycobacteriophages Isolated in East Texas.

Full-genome sequences of seven mycobacteriophages isolated from environmental soil samples are presented. These bacteriophages, with their respective clusters or subclusters are Duplo (A2), Dynamo (P1), Gilberta (A11), MaCh (A11), Nikao (K1), Phloss (N), and Skinny (M1). All had siphovirus-like morphologies, with genome sizes ranging from 43,107 to 82,071 bp.

Examining the Influence of Gender, Child Abuse, and Narcissism on Four Forms of Interpersonal Violence Among Men and Women College Students.

This study examines the moderating effects of gender, child abuse, and pathological narcissism on self-reported stalking, sexual harassment, intimate partner violence, and sexual aggression in undergraduate men and women. Child abuse was positively associated with engaging in all forms of interpersonal violence for both genders. For women, pathological narcissism moderated this association such that higher levels of pathological narcissism reduced the association between child abuse and engaging in stalking, sexual harassment, sexual aggression.

Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.

We describe the synthesis of triazole-containing carboline derivatives and their utility as bromodomain and extra-terminal (BET) inhibitors. A convergent synthetic route permitted the detailed investigation of deuteration and fluorination strategies to reduce clearance while maintaining a favorable profile. This work led to the identification of a potent BET inhibitor, 2-{8-fluoro-3-[4-(H)methyl-1-methyl-1-1,2,3-triazol-5-yl]-5-[()-(oxan-4-yl)(phenyl)methyl]-5-pyrido[3,2-]indol-7-yl}propan-2-ol (), which demonstrated reduced clearance and an improved pharmacokinetic (PK) profile across preclinical species.

Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial.

Patients suffering from fibromyalgia often report stress and pain, with both often refractory to usual drug treatment. Magnesium supplementation seems to improve fibromyalgia symptoms, but the level of evidence is still poor. This study is a randomized, controlled, double-blind trial in fibromyalgia patients that compared once a day oral magnesium 100 mg (Chronomag, magnesium chloride technology formula) to placebo, for 1 month.

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.

Inhibition of the bromodomain and extra-terminal (BET) family of adaptor proteins is an attractive strategy for targeting transcriptional regulation of key oncogenes, such as c-MYC. Starting with the screening hit , a combination of structure-activity relationship and protein structure-guided drug design led to the discovery of a differently oriented carbazole with favorable binding to the tryptophan, proline, and phenylalanine (WPF) shelf conserved in the BET family. Identification of an additional lipophilic pocket and functional group optimization to optimize pharmacokinetic (PK) properties culminated in the discovery of (BMS-986158) with excellent potency in binding and functional assays.

Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.

We describe our efforts to identify structurally diverse leads in the triazole-containing N1-carboline series of bromodomain and extra-terminal inhibitors. Replacement of the N5 "cap" phenyl moiety with various heteroaryls, coupled with additional modifications to the carboline core, provided analogs with similar potency, improved pharmacokinetic properties, and increased solubility compared to our backup lead, BMS-986225 (2). Rapid SAR exploration was enabled by a convergent, synthetic route.

Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88.

Background: Toxoplasma gondii is a globally distributed protozoan parasite that establishes life-long asymptomatic infection in humans, often emerging as a life-threatening opportunistic pathogen during immunodeficiency. As an intracellular microbe, Toxoplasma establishes an intimate relationship with its host cell from the outset of infection. Macrophages are targets of infection and they are important in early innate immunity and possibly parasite dissemination throughout the host.

A vibrational spectroscopic and computational study of the structures of protonated imidacloprid and its fragmentation products in the gas phase.

Infrared multiple photon dissociation (IRMPD) spectroscopy experiments in the 600-2000 cm region and computational chemistry studies were combined with the aim of elucidating the structures of protonated imidacloprid (pIMI), and its unimolecular decomposition products. The computed IR spectra for the lowest energy structures for pIMI as well as for protonated desnitrosoimidacloprid, corresponding to the loss of NO radical (pIMI-NO), and protonated imidacloprid urea corresponding to the loss of NO (pIMIU) were found to reproduce the experimental IRMPD spectrum quite well. The complex IRMPD spectrum for protonated desnitroimidaclpride (pDIMI), resulting from the loss of NO radical from pIMI, was explained as a contribution from several computed structures, including those involving simple loss of NO radical and some isomerization.

Revision and Phylogeny of the Eccritotarsine Plant Bug Genus Caulotops Bergroth, with Descriptions of Four New Genera and 14 New Species (Hemiptera: Heteroptera: Miridae: Bryocorinae) Associated with Agave (Agavoideae: Asparagaceae) and Related Plant Genera.

The bryocorine genus Caulotops Bergroth (Miridae: Eccritotarsini), originally described to accommodate its only species C. puncticollis Bergroth, is shown not to be congeneric with all other species now included in the genus from North, Central, and northern South America. Consequently, four new genera are established for the following 20 species, including five new combinations and 14 species described as new: Agaveocoris n.

Machine Learning and Statistical Models to Predict Postpartum Hemorrhage.

Objective: To predict a woman's risk of postpartum hemorrhage at labor admission using machine learning and statistical models.

Methods: Predictive models were constructed and compared using data from 10 of 12 sites in the U.S.

Impact of Infection on Host Non-coding RNA Responses.

As an intracellular microbe, must establish a highly intimate relationship with its host to ensure success as a parasite. Many studies over the last decade-and-a-half have highlighted how the host reshapes its immunoproteome to survive infection, and conversely how the parasite regulates host responses to ensure persistence. The role of host non-protein-coding RNA during infection is a vast and largely unexplored area of emerging interest.

Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy.

While a fraction of cancer patients treated with anti-PD-1 show durable therapeutic responses, most remain unresponsive, highlighting the need to better understand and improve these therapies. Using an in vivo screening approach with a customized shRNA pooled library, we identified DDR2 as a leading target for the enhancement of response to anti-PD-1 immunotherapy. Using isogenic in vivo murine models across five different tumor histologies-bladder, breast, colon, sarcoma, and melanoma-we show that DDR2 depletion increases sensitivity to anti-PD-1 treatment compared to monotherapy.

Assisting BSN students in moving from novice to advanced beginner through student-LED simulations.

Faculty in a baccalaureate nursing (BSN) program recognized that fundamentals students often expressed a lack of confidence regarding translating knowledge and skills from long-term care environments into acute medical-surgical environments. This study used Benner's novice to expert framework as the basis for designing and implementing a peer-coached student led simulation with the aim of easing student transition from novice to advanced beginner. A mixed-methods descriptive design was used to gather and analyze qualitative data from peer-coach and learner focus groups.

Mesquite bugs, other insects, and a bat in the diet of pallid bats in southeastern Arizona.

The pallid bat () is a species of western North America, inhabiting ecoregions ranging from desert to oak and pine forest. They are primarily insectivorous predators on large arthropods that occasionally take small vertebrate prey, and are at least seasonally omnivorous in certain parts of their geographic range where they take nectar from cactus flowers and eat cactus fruit pulp and seeds. Until recently, mesquite bugs were primarily tropical-subtropical inhabitants of Mexico and Central America but have since occupied the southwestern United States where mesquite trees occur.

New genus and two new species of Hyaliodini from the Philippines (Miridae, Deraeocorinae).

, a new genus of the mirid subfamily Deraeocorinae, tribe Hyaliodini, is described from the Philippines. New species and from the island of Luzon are documented with photographic images of the dorsal habitus and male genital structures.

A description of a new genus and new species of sotol-feeding Eccritotarsini (Hemiptera: Heteroptera: Miridae: Bryocorinae) from Durango, Mexico.

The new genus and species Sotolensis keltoni is described in the Eccritotarsini (Miridae: Bryocorinae) from material collected on expeditions to Durango, Mexico, by Leonard A. Kelton from the Canadian National Collection. All specimens collected were found on sotol, or Dasylirion sp.

Toxoplasma gondii Manipulates Expression of Host Long Noncoding RNA during Intracellular Infection.

Long noncoding RNA (lncRNA) are non-protein-coding transcripts greater than 200 nucleotides that regulate gene expression. The field of transcriptomics is only beginning to understand the role of lncRNA in host defense. Little is known about the role of lncRNA in the response to infection by intracellular pathogens such as Toxoplasma gondii.

Concurrent 5-fluorouracil and carboplatin for the treatment of canine carcinomas.

5-Fluorouracil (5-FU) is used in combination chemotherapy protocols for human head and neck cancer and other epithelial neoplasms. However, a paucity of literature describing use of this drug in veterinary oncology exists, likely due to previous reports of fatal neurotoxicity in both dogs and cats, mainly due to ingestion of human creams. The primary aim of this retrospective study was to report the safety of concurrent 5-FU and carboplatin in canine carcinomas.

The Role of Gender, Child Maltreatment, Alcohol Expectancies, and Personality Pathology on Relationship Violence Among Undergraduates.

Male ( = 1,104) and female ( = 1,337) college students' self-report surveys on childhood maltreatment, alcohol expectancies, and narcissistic personality traits are examined to determine their associations with relationship violence. Intimate partner violence was measured using the violence subscales of the revised Conflict Tactics. Because we were interested in the effects of gender and because tests of the correlations and tests of means indicated men and women differed significantly on several variables, ordinary least squares regression models were run separately for men and women.

Friendships Lost: The Social Consequences of Violent Victimization.

Few studies have examined the impact of violent victimization on friendship networks. This study used two waves of data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine the effects of violent victimization on number peer- and self-reported friendships. Guided by stigma theory (Goffman, 1963), fixed-effect regression models controlling for depression, delinquency, substance use, and school engagement were completed to predict changes in number of friends following victimization.

LepNet: The Lepidoptera of North America Network.

The Lepidoptera of North America Network, or LepNet, is a digitization effort recently launched to mobilize biodiversity data from 3 million specimens of butterflies and moths in United States natural history collections (http://www.lep-net.org/).