Publications by authors named "Menaka Priyadharsani Rajapakse"
Article Synopsis
- Tumor microenvironment (TME) plays an important role in how tumors grow and respond to treatment, but scientists still don't fully understand how different cells in the TME interact with each other.
- Traditional methods can show the shapes and positions of these cells, but they can't collect a lot of detailed information all at once.
- New technologies called spatial omics are helping researchers collect more information about these cells while keeping track of where they are located, and AI is being used to help make sense of all this complex data.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have become dominant as the pandemic progresses bear the ORF8 mutation together with multiple spike mutations. A 382-nucleotide deletion (Δ382) in the ORF7b and ORF8 regions has been associated with milder disease phenotype and less systemic inflammation in COVID-19 patients. However, its impact on host immunity against SARS-CoV-2 remains undefined.
View Article and Find Full Text PDFAfrican horse sickness (AHS) is a highly infectious and deadly disease despite availability of vaccines. Molecular characterization of African horse sickness virus (AHSV) detected from the March 2020 Thailand outbreak was carried out by whole-genome sequencing using Nanopore with a Sequence-Independent Single Primer Amplification (SISPA) approach. Nucleotide sequence of the whole genome was compared with closest matching AHSV strains using phylogenetic analyses and the AHSV-1 virus shared high sequence identity with isolates from the same outbreak.
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