Publications by authors named "Mena S Yamany"
Nat Biotechnol
September 2018
Article Synopsis
- Increased tryptophan (Trp) breakdown in tumors leads to immune suppression, primarily through the enzymes IDO1 and TDO, and the resulting accumulation of kynurenine (Kyn) is believed to play a key role in this process.
- A new treatment using PEGylated kynureninase (PEG-KYNase) effectively breaks down Kyn into harmless byproducts, which helps inhibit tumor growth and boosts the presence of active immune cells.
- When used alongside existing cancer therapies like checkpoint inhibitors or vaccines, PEG-KYNase shows significant therapeutic benefits in various cancer models, effectively countering the immune-suppressive effects associated with Trp metabolism in the tumor microenvironment.
