Publications by authors named "Men Yu"
Antimicrobial peptides (AMPs) are small, potent molecules that serve as a crucial first line of defense across a wide range of organisms, including fish. In this study, we investigated the antimicrobial properties of a novel peptide, spanning residues 52 to 80 of the full-length histone H2A protein, comprising a total of 29 amino acids. This peptide, designated as Histone H2A-29 (TroH2A-29), was derived from the golden pompano (Trachinotus ovatus) and evaluated for its activity against both Gram-positive bacteria, Lactococcus garvieae and Staphylococcus epidermidis, and Gram-negative bacteria, Vibrio alginolyticus and Vibrio harveyi.
View Article and Find Full Text PDFPurpose: The therapeutic advantage of postoperative radiation therapy (PORT) for non-small cell lung cancer (NSCLC) has not been shown to benefit overall survival (OS) according to two randomized controlled trials (RCTs), albeit an enhancement in locoregional-free survival was observed. We aimed to evaluate the relative influence of locoregional recurrence (LR) and distant metastasis (DM) on OS for patients with NSCLC after surgery.
Methods: This was a secondary analysis of PORT-C RCT.
Article Synopsis
- The study focused on sperm storage in black rockfish and how the female reproductive system adapts to this, revealing that sperm are stored in specific locations during different reproductive stages.
- A total of 5012 proteins were identified, showing significant changes in expression at the pre-fertilization stage, with 140 proteins upregulated and 615 downregulated compared to pre-mating.
- The research indicated that specific signaling pathways related to vesicle sorting, hormone signaling, and immune response are crucial for oocyte development and sperm storage, providing useful insights for reproductive biology and aquaculture.
Objectives: This study aimed to develop and validate a deep-learning radiomics model using CT, T2, and DWI images for predicting pathological complete response (pCR) in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemoradiotherapy (nCRT).
Materials And Methods: Patients with ESCC undergoing nCRT followed by surgery were retrospectively enrolled from three institutions and divided into training and testing cohorts. Both traditional and deep-learning radiomics features were extracted from pre-treatment CT, T2, and DWI.
Introduction: The estimated dose of radiation to immune cells (EDRIC) has been shown to correlate with the overall survival (OS) of patients who receive definitive thoracic radiotherapy. However, the planning target volume (PTV) may be a confounding factor. We assessed the prognostic value of EDRIC for non-small cell lung cancer (NSCLC) in patients who underwent postoperative radiotherapy (PORT) with homogeneous PTV.
View Article and Find Full Text PDFPurpose: We aimed to integrate MR radiomics and dynamic hematological factors to build a model to predict pathological complete response (pCR) to neoadjuvant chemoradiotherapy (NCRT) in esophageal squamous cell carcinoma (ESCC).
Methods: Patients with ESCC receiving NCRT and esophagectomy between September 2014 and September 2022 were retrospectively included. All patients underwent pre-treatment T2-weighted imaging as well as pre-treatment and post-treatment blood tests.
Purpose: Initial studies investigating the combination of local and systemic treatments in advanced esophageal cancer (EC) have conflicting conclusions regarding survival benefits. The objective of this systematic review and meta-analysis is to assess the efficacy of the addition of local therapy to systemic treatments in patients with advanced EC.
Methods And Materials: A systematic literature search was conducted in the PubMed, EMBASE, and CENTRAL databases.
Article Synopsis
- Fish germ cell transplantation shows promise for protecting endangered species and enhancing fish breeds, but low effectiveness is a major challenge.
- This study transplanted fat greenling spermatogonia into spotted sea bass and found that over 90% of the cells died within 10 days due to apoptosis.
- The research revealed that the apoptosis was linked to immune rejection, with specific genes and proteins (PRF1 and GZMB) from the sea bass contributing to the loss of transplanted cells.
Article Synopsis
- The study investigates the effectiveness of postoperative radiotherapy (PORT) for patients with non-small cell lung cancer (NSCLC) and aims to identify specific patients who might benefit from it.
- A radiomic prognostic index (RPI) based on texture features from preoperative chest CT scans was created, and a lymph-radiomic prognostic index (LRPI) was established by combining RPI with the number of positive lymph nodes.
- Results reveal that patients categorized as moderate-risk (based on the LRPI) saw improved overall survival with PORT, while low-risk and high-risk patients did not benefit, indicating the potential to tailor treatment based on individual risk assessment.
Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer, and accurately predicting patient prognosis is difficult.
- Researchers collected histopathological images and clinical data, divided them into training and validation groups, and applied machine learning techniques to identify important features and genes influencing prognosis.
- The resulting histopathological-genetic risk score (HGRS) showed strong predictive capabilities for overall survival and outperformed models relying solely on imaging features, ultimately leading to a nomogram that integrates several predictive indicators for enhanced prognostic assessment in ccRCC patients.
Article Synopsis
- The study focuses on the testis development in adult black rockfish throughout the annual cycle, utilizing single-cell transcriptome sequencing to analyze cellular changes.
- It outlines the continuous developmental pathway of spermatogenic cells, emphasizing the gene expression dynamics related to spermatogonia proliferation and differentiation.
- Furthermore, it highlights the complex interactions between various testicular cells, which may aid in understanding spermatogenesis and contribute to the preservation of endangered species.
Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0-C26) within 10-min with good sensitivity (limit of detection < 0.
View Article and Find Full Text PDFArticle Synopsis
- * This study developed and validated a machine learning model using MR radiomics to predict pCR in ESCC patients, involving 155 participants from two institutions across different timeframes.
- * The model demonstrated high accuracy, with an area under the curve (AUC) of 0.885 in the testing set, and achieved an accuracy of 82.2%, highlighting its potential as a reliable predictive tool for treatment outcomes in ESCC.
Research on Robot Screwing Skill Method Based on Demonstration Learning.
Sensors (Basel)
December 2023
Article Synopsis
- A new robot learning framework is introduced that enhances robots' ability to generalize tasks like screwing by integrating human techniques.
- The framework involves teaching, learning, and summarizing tasks, focusing on trajectory mapping and addressing obstacles using advanced models.
- Experiments show that the robot can navigate obstacles and perform various screwing tasks effectively, demonstrating the model's success and adaptability to different environments.
Background: The true bugs (Heteroptera) occupy nearly all of the known ecological niches of insects. Among them, as a group containing more than 30,000 species, the phytophagous true bugs are making increasing impacts on agricultural and forestry ecosystems. Previous studies proved that symbiotic bacteria play important roles in these insects in fitting various habitats.
View Article and Find Full Text PDFBackground: Radiotherapy-induced esophagitis (RE) diminishes the quality of life and interrupts treatment in patients with non-small cell lung cancer (NSCLC) undergoing postoperative radiotherapy. Dosimetric models showed limited capability in predicting RE. We aimed to develop dosiomic models to predict RE.
View Article and Find Full Text PDFAmong hundreds of insect families, Hermatobatidae (commonly known as coral treaders) is one of the most unique. They are small, wingless predaceous bugs in the suborder Heteroptera. Adults are almost black in colour, measuring about 5 mm in body length and 3 mm in width.
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- The study investigates how heart and lung doses during postoperative radiation therapy (PORT) affect overall survival in patients with non-small cell lung cancer (NSCLC).
- A retrospective analysis of 307 patients reveals that higher heart doses correlate with poorer long-term survival outcomes, while higher lung doses are linked to reduced survival in the early stages.
- Results highlight the importance of minimizing radiation exposure to the heart and lungs to improve survival rates in NSCLC patients after PORT.
Introduction: Adjuvant radiotherapy is recommended for pT1b esophageal squamous cell cancer (ESCC) after endoscopic submucosal dissection (ESD). However, it is unclear whether additional radiotherapy can improve patient survival. This study aimed to evaluate the efficacy of adjuvant radiotherapy after ESD for pT1b ESCC.
View Article and Find Full Text PDFBackground: Significant progress has been made in the investigation of neoadjuvant immune-chemoradiotherapy (NICRT) and neoadjuvant immune-chemotherapy (NICT) on the outcomes of esophageal cancer patients. To summarize the current developments, a systematic review and meta-analysis were conducted to evaluate the efficacy and safety of neoadjuvant immunotherapy combined with chemoradiotherapy or chemotherapy.
Methods: A search strategy of prospective studies on esophageal cancer receiving neoadjuvant immunotherapy was predefined to scan PubMed, Embase, Cochrane, and additional major conferences for prospective studies.
Article Synopsis
- Direct membrane filtration (DMF) technology generates energy by utilizing carbon from municipal wastewater, but it faces significant challenges due to membrane fouling.
- Research was conducted using a DMF reactor to explore the effects of different fouling control strategies: no control, intermittent aeration, and periodic backwash, with effective results in reducing chemical oxygen demand.
- Findings revealed that most membrane fouling came from free proteins and large particles, and the combined approach of backwashing and aeration significantly improved fouling control, suggesting optimal strategies for long-term DMF operation.
Background: Results from Lung ART and PORT-C trials suggest that postoperative radiotherapy (PORT) cannot routinely be recommended as standard treatment in completely resected pIIIA-N2 NSCLC patients, but their effects on the real-world practice of PORT in China remain unclear.
Methods: A national cross-section survey was conducted by using an online survey service. Participants were voluntarily recruited using a river sampling strategy.
True bugs (Hemiptera, suborder Heteroptera) constitute the largest suborder of nonholometabolous insects and occupy a wide range of habitats various from terrestrial to semiaquatic to aquatic niches. The transition and occupation of these diverse habitats impose various challenges to true bugs, including access to oxygen for the aquatic species and plant defense for the terrestrial phytophagans. Although numerous studies have demonstrated that microorganisms can provide multiple benefits to terrestrial host insects, a systematic study with comprehensive higher taxa sampling that represents aquatic and semiaquatic habitats is still lacking.
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