Adverse Drug Reactions in Paediatric In-Patients in a South African Tertiary Hospital.

Background: The prevalence of adverse drug reaction (ADR) rates in children in sub-Saharan Africa is unknown.

Objectives: To describe the prevalence of ADRs in paediatric in-patients at a tertiary hospital in South Africa.

Methods: This is a prospective study during a 3-month study period.

Off-label Use in Ambulatory Paediatric Clinics in a Central South African Hospital.

Aim: The aim of this article was to determine off-label (OL) use in paediatric ambulatory clinics in a South African central hospital.

Patients And Methods: OL medicine events were documented in three paediatric clinics (general, highly specialized and dedicated HIV paediatric clinics) at Tygerberg Hospital, South Africa, and analysed according to South African medicine registration information.

Results: There were 2167 medicine events for 658 children.

Critical evaluation of causality assessment of herb-drug interactions in patients.

The aim of this review was to assess the severity of adverse drug reactions (ADRs) due to herb-drug interactions (HDI) in patients taking herbs and prescribed medications based on published evidence. Electronic databases of PubMed, the Cochrane Library, Medline and Scopus were searched for randomized or nonrandomized clinical studies, case-control and case reports of HDI. The data were extracted and the causal relationship of ADRs as consequences of HDI assessed using Horn's drug interaction probability scale or Roussel Uclaf Causality Assessment Method scoring systems.