Publications by authors named "Melwyn Luis Muthukkattil"
Atrial fibrillation (AF) is the most common arrhythmia in patients affected by cardiomyopathies. Reports estimate a prevalence of 27% in patients with hypertrophic cardiomyopathy (HCM) and 40% in patients with cardiac amyloidosis (CA). The presence of AF typically results in progressive functional decline, an increased frequency of hospitalizations for heart failure, and a higher thromboembolic risk.
View Article and Find Full Text PDFWhat about chronotropic incompetence in heart failure with mildly reduced ejection fraction? Clinical and prognostic implications from the Metabolic Exercise combined with Cardiac and Kidney Indexes score dataset.
Eur J Prev Cardiol
January 2024
Article Synopsis
- The study investigates chronotropic incompetence (CI) in heart failure with mildly reduced ejection fraction (HFmrEF) patients, focusing on its prevalence and effects on exercise capacity and cardiovascular outcomes.
- Data from 864 stable HFmrEF outpatients showed significant variations in CI prevalence based on measurement methods, with a notable 9.7% rate of cardiovascular deaths over the study period.
- The findings indicate that a blunted heart rate response during exercise is linked to lower functional capacity and increased cardiovascular death risk, suggesting the need for further research to determine if CI should be included in standard management for HFmrEF patients.
A minority of patients with severe acute respiratory syndrome coronavirus 2 (COVID-19) develop cardiovascular complications, such as acute cardiac lesions with elevated troponins, de novo systolic heart failure, pericardial effusion and, rarely, acute myocarditis. The prevalence of COVID-19-related myocarditis ranges from 10 to 105 cases per 100,000 COVID-19-infected individuals, with a male predominance (58%) and a median age of 50 years. The etiopathogenetic mechanism is currently unclear, but may involve direct virus-mediated damage or an exaggerated immune response to the virus.
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