Publications by authors named "Melvin Wei Shern Goh"

Artificial lipid bilayer systems, such as vesicles, black membranes, and supported lipid bilayers (SLBs), are valuable platforms for studying ion channels at the molecular level. The reconstitution of the ion channels in an active form is a crucial process in studies using artificial lipid bilayer systems. In this study, we investigated the assembly of the human related gene (hERG) channel prepared in a cell-free synthesis system.

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Domain formation in "HLC" ternary lipid bilayers, comprising a high transition temperature (High-T) lipid, a Low-T lipid, and cholesterol (Chol), has been extensively studied as raft-resembling systems. Recently, we reported the formation of submicron domains in an "LLC" lipid bilayer, encompassing Low-T phosphatidylethanolamine (PE), Low-T phosphatidylcholine (PC), and Chol. We hypothesized that the formation of this unique domain is driven by polyunsaturated PE.

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Recently, we reported that a ternary lipid bilayer comprising phosphatidylethanolamine (PE), phosphatidylcholine (PC), which were both derived from chicken egg, and cholesterol (Chol) generates microdomains that function as specific fusion sites for proteoliposomes. Chol-induced microdomain formation in a completely miscible lipid bilayer is an exceptional phenomenon. Numerous studies have elucidated the formation of domains in liquid ordered (L) and liquid disordered (L) phases of ternary bilayers, which comprise two partially miscible lipids and Chol.

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