Publications by authors named "Melvin Baidya"
Article Synopsis
- Randomized clinical trials indicate that BTK inhibitors (BTKis) may heighten the risk of infectious diseases (IDs), prompting the need for systematic analysis based on both clinical practices and trial data.
- A thorough review of peer-reviewed sources from 2014 to 2023 was conducted to assess ID morbidity in patients taking BTKis, taking into account immune defects present in patients with indolent B-cell lymphomas.
- The findings highlight a significant association between BTKi usage and increased incidents of upper respiratory infections and invasive fungal infections, underscoring the need for better understanding and management of these risks to enhance patient outcomes.
Shone syndrome was first described in 1963 by Dr JD Shone. It is a constellation of congenital abnormalities compromising approximately 0.6% of all cases of congenital cardiac abnormalities.
View Article and Find Full Text PDFSmall molecule interactions with amyloid proteins have had a huge impact in Alzheimer's disease (AD), especially in three specific areas: amyloid folding, metabolism and brain imaging. Amyloid plaque amelioration or prevention have, until recently, driven drug development, and only a few drugs have been advanced for use in AD. Amyloid proteins undergo misfolding and oligomerization via intermediates, eventually forming protease resistant amyloid fibrils.
View Article and Find Full Text PDFThe nematode C. elegans utilizes a relatively simple neural circuit to mediate avoidance responses to noxious stimuli such as the volatile odorant octanol. This avoidance behavior is modulated by dopamine.
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