Publications by authors named "Melvin A Sarayba"
Background And Objective: To explore the association between best-corrected visual acuity (BCVA) improvement and changes in microperimetry (MP) and color vision in patients with nonexudative age-related macular degeneration following administration of two 1.0-mg intravitreal doses of risuteganib.
Patients And Methods: In a phase 2a, prospective, double-masked, sham-controlled study, eyes with nonexudative age-related macular degeneration and Early Treatment Diabetic Retinopathy Study BCVA between 20/40 and 20/200 were randomized to intravitreal risuteganib (1.
Safety and Efficacy of Intravitreal Risuteganib for Non-Exudative AMD: A Multicenter, Phase 2a, Randomized, Clinical Trial.
Ophthalmic Surg Lasers Imaging Retina
June 2021
Background And Objective: To evaluate the safety and efficacy of 1.0 mg risuteganib in subjects with nonexudative age-related macular degeneration (AMD).
Patients And Methods: This was a phase 2a, prospective, double-masked, sham-controlled study.
Purpose: To evaluate corneal stromal bed quality of lamellar keratectomy in laser in situ keratomileusis (LASIK) procedures by using mechanical and femtosecond laser microkeratomes.
Methods: LASIK corneal flaps were created in 9 fresh human globes not suitable for transplantation. We grouped the samples into 3 different groups of 3 globes each.
Purpose: To compare the stromal surfaces created by the latest mechanical microkeratome and femtosecond, laser technologies.
Methods: Laser in situ keratomileusis (LASIK) flaps were created in six fresh human globes unsuitable for transplantation. The eyes were placed in one of two groups of three globes each.
Purpose: To determine the feasibility of using a modified femtosecond laser to perform penetrating corneal resections.
Design: Controlled laboratory study.
Methods: Fourteen corneoscleral rims were mounted on an artificial anterior chamber.
Purpose: To evaluate the thickness and diameter accuracy of the IntraLase femtosecond laser in harvesting corneal discs for lamellar keratoplasty. The stromal bed quality of resected corneas was evaluated by scanning electron microscopy.
Methods: Two IntraLase units were used to create corneal discs at 225-, 300-, 400-, and 500-microm thickness settings and 7-, 8-, 8.
Purpose: To evaluate the mechanical stability and induced astigmatism of a modified multiplanar "top hat" wound configuration for full-thickness penetrating keratoplasty (PK) using the femtosecond laser as compared with PK in a laboratory model.
Methods: Eight human corneoscleral rims were mounted on an artificial anterior chamber. Four samples were assigned to the traditional PK group.
Purpose: To demonstrate femtosecond laser-assisted intracorneal keratoprosthesis implantation and determine the mechanical stability as a function of intraocular pressure.
Methods: Eight human corneoscleral rims were mounted on an artificial anterior chamber. The femtosecond laser microkeratome was used to create a 2.
Fluoroquinolone therapy in Mycobacterium chelonae keratitis after lamellar keratectomy.
J Cataract Refract Surg
July 2005
Purpose: To characterize a rabbit model of Mycobacterium chelonae keratitis after lamellar keratectomy and assess the effectiveness of fluoroquinolone therapy.
Setting: University Laboratory, University of California, Irvine, California, USA.
Methods: Twenty-eight New Zealand white rabbits had unilateral lamellar keratectomy with placement of 2.
Background: Sutureless clear corneal cataract incisions may be associated with an increased risk of endophthalmitis.
Objective: To assess the degree of ocular surface fluid ingress into the anterior chamber of cadaveric human globes with clear corneal wounds.
Methods: Self-sealing clear corneal incisions were created in 4 eyes, and intraocular pressure was controlled with an infusion cannula.
Purpose: To evaluate feasibility of femtosecond laser application in posterior lamellar keratoplasty.
Methods: To evaluate the laser's effectiveness through opaque corneas, anterior corneal caps were resected from opaque corneas induced with 80% acetone solution. To evaluate the femtosecond laser posterior lamellar keratoplasty surgical procedure, human corneoscleral rims were mounted on an artificial anterior chamber.
Purpose: To describe a surgical technique using an artificial anterior chamber to facilitate harvest of Descemet's membrane (DM) and endothelium for corneal endothelial cell transplantation.
Design: Laboratory investigation.
Methods: Corneoscleral buttons of seven human donor eyes were mounted endothelial side up on an artificial anterior chamber.
Purpose: To measure and compare the changes in objective wavefront aberration and subjective manifest refraction after laser in situ keratomileusis (LASIK) flap creation with a mechanical microkeratome and a femtosecond laser.
Setting: Private practice refractive surgery center, Irvine, California, USA.
Methods: This randomized prospective study comprised 9 patients (18 eyes) treated with a 2-step LASIK procedure: lamellar keratectomy with a Hansatome microkeratome (Bausch & Lomb) or the IntraLase femtosecond laser in fellow eyes followed by non-wavefront-guided (standard) excimer laser treatment with the Technolas 217A (Bausch & Lomb) excimer laser 10 weeks later.
Purpose: To determine the efficacy of the peroxisome proliferator-activated receptor gamma agonist, pioglitazone, in inhibiting corneal neovascularization.
Methods: Twenty-six adult male Sprague-Dawley rats were randomly divided into three groups. Each group received intrastromal polymer micropellets containing one of the following: Group 1, no active ingredient (n=10); Group 2, vascular endothelial growth factor (VEGF) (n=7); Group 3, VEGF and pioglitazone (n=9).
Purpose: To evaluate the self-sealing properties of standard clear corneal cataract incisions during two events: (1) application of mechanical external pressure, or (2) controlled fluctuation of intraocular pressure (IOP).
Design: Laboratory investigation.
Methods: Eight fresh human donor globes were prepared for Miyake video microscopy.
A portable, gas-driven turbine microkeratome device capable of harvesting the entire anterior corneal surface for lamellar transplantation on human donor globes was evaluated. The device consisted of a modified LASIK microkeratome with an enlarged suction ring, head, and blade. Vacuum was achieved by a simple hand pump.
View Article and Find Full Text PDFObjective: To determine the viability in cold eye bank storage of different layers of central and limbal corneal epithelium, including the limbal basal stem cell population, on days 0, 3, 6, and 9 after harvest using a large diameter microkeratome system.
Methods: Twenty-two human whole globes not suitable for transplantation were obtained from an eye bank (San Diego Eye Bank, San Diego, California) and used for study. Large-diameter anterior corneal discs were prepared using a large diameter microkeratome and stained with calcein AM and an ethidium homodimer to differentiate live from dead cells, respectively.
Purpose: To assess the effectiveness of a fourth-generation fluoroquinolone for prophylaxis against multiple drug-resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model.
Design: Experimental study.
Methods: Twenty-eight New Zealand white rabbits underwent unilateral lamellar keratectomy using a manual microkeratome followed by the placement of 1000 colony-forming units (CFUs) of log-phase Staphylococcus aureus bacteria under each flap.
Purpose: To determine the reproducibility of anterior sclerokeratectomy using a portable nonelectric microkeratome-based device capable of harvesting the entire anterior corneal surface for lamellar transplantation.
Methods: A modified gas turbine-driven microkeratome (LSK One, Moria/Microtech, Doylestown, PA) with a redesigned head large enough to incorporate the whole human anterior corneal surface in a pass and was coupled to a manual vacuum pump. This instrument was tested on 25 fresh porcine globes divided into 2 groups (170-microm and 200-microm head).