Publications by authors named "Meltzanidou Parthena"
Article Synopsis
- * Results showed that patients carrying a common genetic variant (GGG haplotype) had a significantly better response to ADA after 12 weeks compared to those with less common SNPs, with response rates of 71.8% vs. 50.0%.
- * The findings suggest that those with minor SNP haplotypes had a lower improvement in certain measures of disease severity, indicating that genetic makeup could influence treatment outcomes and should be considered in clinical decisions.
Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus. Since interleukin-1 receptor-associated kinase (IRAK-1)/nuclear factor-kappa B (NF-kappa B) pathway plays an essential role in the pathogenesis of autoimmune diseases, the aim of the present study was to explore the role of polymorphisms in three genes, named IRAK1 (rs3027898), NFKBIA (rs696) and NFKB1 (-94ATTG insertion/deletion variant, - rs28362491), in PV susceptibility. Forty-four unrelated patients with PV (23 males) were enrolled in the study.
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- * Desmocollin-3 (Dsc-3), a protein implicated in skin cell adhesion, has been previously linked to blister formation in mice, with some studies suggesting the presence of autoantibodies against it in humans.
- * This study examined Greek patients with PV and PF and found no evidence of IgG autoantibodies against Dsc-3, supporting the idea that Dsc-3's role in causing epidermal blistering in