A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding.

In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.

Excited State Intramolecular Proton Transfer (ESIPT)-Based Sensor for Ion Detection.

C-2 and C-5 substituted imidazole skeleton was synthesized through a one-pot two-step strategy. Synthesized molecule emits the light on ESIPT (excited-state intramolecular proton transfer). This molecule was utilized for its proton donor ability, and we have observed that fluoride and cyanide ions can be detected selectively.

Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases.

Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the test compound donepezil and higher than that of tacrine. Structure activity relationship studies, docking studies to on X-ray crystal structure of AChE with PDB code 1B41, and adsorption, distribution, metabolism, and excretion (ADME) predictions were performed.

3,5-Dibenzoyl-2,6-dimethyl-1-pentyl-4-pyridone.

In the crystal structure of the title compound, C(26)H(27)NO(3), a one-dimensional network of C-H⋯O hydrogen bonds and π-ring inter-actions is responsible for crystal stabilization. Inter-molecular hydrogen bonds and C-H⋯ π inter-actions produce R(2) (2)(10), R(4) (4)(27) and R(4) (4)(29) rings.